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Fbxo46 Fbxo46 Fbxl19 Fbxl19 Skp2 Skp2 Fbxl21 Fbxl21 Fbxl3 Fbxl3 Fbxl4 Fbxl4 Ect2l Ect2l Fbxw11 Fbxw11 Fbxw8 Fbxw8 Fbxo42 Fbxo42 Fbxl5 Fbxl5 Fbxw4 Fbxw4 M0RA85_RAT M0RA85_RAT Fbxo31 Fbxo31 Fbxl13 Fbxl13 Fbxl20 Fbxl20 Ccnf Ccnf Fbxo44 Fbxo44 Fbxo33 Fbxo33 Fbxo15 Fbxo15 Kdm2a Kdm2a Kdm2b Kdm2b Fbxw7 Fbxw7 Fbxo24 Fbxo24 Fbxo5 Fbxo5 Fbxo48 Fbxo48 Fbxl7 Fbxl7 Fbxl2 Fbxl2 Fbxw5 Fbxw5 Fbxw12 Fbxw12 Fbxo17 Fbxo17 Fbxw2 Fbxw2 Fbh1 Fbh1 Fbxo36 Fbxo36 Btrc Btrc Fbxo11 Fbxo11 Fbxo4 Fbxo4 Fbxl8 Fbxl8 Fbxo39 Fbxo39 Fbxo30 Fbxo30 Fbxo16 Fbxo16 Fbxl18 Fbxl18 Fbxw9 Fbxw9 Fbxo6 Fbxo6 Fbxo10 Fbxo10 Fbxo34 Fbxo34 Fbxo3 Fbxo3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Fbxo46F-box only protein 46; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (603 aa)
Fbxl19F-box and leucine-rich repeat protein 19. (674 aa)
Skp2S-phase kinase-associated protein 2 (P45). (423 aa)
Fbxl21F-box and leucine-rich repeat protein 21. (434 aa)
Fbxl3F-box and leucine-rich repeat protein 3, isoform CRA_a. (428 aa)
Fbxl4F-box and leucine-rich repeat protein 4 (Predicted), isoform CRA_c. (621 aa)
Ect2lEpithelial cell-transforming 2-like. (846 aa)
Fbxw11F-box and WD repeat domain-containing 11. (531 aa)
Fbxw8F-box/WD repeat-containing protein 8; Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitinatio [...] (596 aa)
Fbxo42F-box protein 42. (717 aa)
Fbxl5F-box and leucine-rich repeat protein 5. (690 aa)
Fbxw4F-box and WD-40 domain protein 4 (Predicted). (408 aa)
M0RA85_RATUncharacterized protein. (235 aa)
Fbxo31F-box only protein 31; Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity); Belongs to the FBXO31 family. (507 aa)
Fbxl13F-box and leucine-rich repeat protein 13. (590 aa)
Fbxl20F-box/LRR-repeat protein 20; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity). (436 aa)
CcnfCyclin-F; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. Belongs to the cyclin family. Cyclin AB subfamily. (780 aa)
Fbxo44F-box protein 44. (255 aa)
Fbxo33F-box only protein 33 (Predicted). (467 aa)
Fbxo15F-box protein 15. (458 aa)
Kdm2aF-box and leucine-rich repeat protein 11 (Predicted). (1161 aa)
Kdm2bLysine demethylase 2B. (1078 aa)
Fbxw7F-box/WD repeat-containing protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (By similarity). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1 and probably PSEN1 (By similarity). Acts as a nega [...] (713 aa)
Fbxo24F-box protein 24. (590 aa)
Fbxo5F-box only protein 5 (Predicted). (418 aa)
Fbxo48Similar to RIKEN cDNA A630050E13 gene (Predicted). (160 aa)
Fbxl7F-box and leucine-rich repeat protein 7. (444 aa)
Fbxl2F-box and leucine-rich repeat protein 2. (438 aa)
Fbxw5F-box/WD repeat-containing protein 5; Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes req [...] (569 aa)
Fbxw12F-box and WD repeat domain-containing 12. (466 aa)
Fbxo17F-box only protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Also recognizes sulfated glycans. Does not bind high- mannose glycoproteins (By similarity). (250 aa)
Fbxw2F-box/WD repeat-containing protein 2; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (454 aa)
Fbh1F-box only protein 18 (Predicted). (1042 aa)
Fbxo36F-box only protein 36 (Predicted), isoform CRA_a. (188 aa)
BtrcBeta-transducin repeat-containing E3 ubiquitin protein ligase. (587 aa)
Fbxo11F-box only protein 11; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cel [...] (843 aa)
Fbxo4F-box only protein 4 (Predicted). (431 aa)
Fbxl8Similar to F-box and leucine-rich repeat protein 8 (Predicted). (374 aa)
Fbxo39F-box only protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. (443 aa)
Fbxo30F-box only protein 30; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. (742 aa)
Fbxo16F-box protein 16. (334 aa)
Fbxl18F-box and leucine-rich repeat protein 18. (656 aa)
Fbxw9F-box and WD repeat domain-containing 9. (458 aa)
Fbxo6F-box only protein 6; Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high- mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved i [...] (284 aa)
Fbxo10F-box protein 10. (970 aa)
Fbxo34F-box only protein 34 (Predicted), isoform CRA_b. (732 aa)
Fbxo3F-box only protein 3; Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2, and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). (480 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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