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Gstt1 | Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. (240 aa) | ||||
Chac2 | Putative glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. (178 aa) | ||||
Lap3 | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). (519 aa) | ||||
Mgst3 | Microsomal glutathione S-transferase 3. (152 aa) | ||||
Odc1 | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa) | ||||
Hpgds | Hematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family. (199 aa) | ||||
Sms | Spermine synthase. (366 aa) | ||||
Mgst1 | Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (155 aa) | ||||
Txndc12 | Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity. (170 aa) | ||||
Gpx7 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa) | ||||
Gpx8 | Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa) | ||||
Srm | Spermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa) | ||||
Gsto1 | Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. (241 aa) | ||||
Gsto2 | Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. (248 aa) | ||||
Gsta1 | Glutathione S-transferase alpha-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide. (221 aa) | ||||
Gclm | Glutamate--cysteine ligase regulatory subunit. (274 aa) | ||||
Idh2 | Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity). (452 aa) | ||||
Chac1 | Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Not [...] (222 aa) | ||||
Idh1 | Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa) | ||||
Nat8f3 | N-acetyltransferase family 8 member 3; Has histone acetyltransferase activity in vitro, with specificity for histone H4. (228 aa) | ||||
Gstk1 | Glutathione S-transferase kappa 1; Might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment; Belongs to the GST superfamily. Kappa family. (226 aa) | ||||
Gstp1 | Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). (210 aa) | ||||
Ggt7 | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. (662 aa) | ||||
Gss | Glutathione synthetase; Belongs to the eukaryotic GSH synthase family. (474 aa) | ||||
Gstm6 | Glutathione S-transferase. (218 aa) | ||||
Gstm3l | Glutathione S-transferase. (218 aa) | ||||
Gstm4 | Glutathione S-transferase. (218 aa) | ||||
RGD1562107 | Similar to class-alpha glutathione S-transferase. (222 aa) | ||||
Prdx6 | Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa) | ||||
Gsta6 | Glutathione S-transferase A6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa) | ||||
RGD1562036 | Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa) | ||||
Gclc | Glutamate--cysteine ligase catalytic subunit. (637 aa) | ||||
Rrm2b | Ribonucleotide reductase regulatory TP53-inducible subunit M2B. (351 aa) | ||||
Gstm1 | Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process. (216 aa) | ||||
Ggt6 | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates. (498 aa) | ||||
Gsta2 | Glutathione S-transferase alpha-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (222 aa) | ||||
Ggct | Gamma-glutamyl cyclotransferase. (188 aa) | ||||
Gstt3 | Similar to Glutathione S-transferase, theta 3 (Predicted); Belongs to the GST superfamily. (210 aa) | ||||
Gstt4 | Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family. (240 aa) | ||||
Nat8f5 | Probable N-acetyltransferase CML5; May play a role in regulation of gastrulation. Belongs to the camello family. (227 aa) | ||||
Rrm1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa) | ||||
LOC100910829 | N-acetyltransferase family 8 member 2; Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4. Belongs to the camello family. (226 aa) | ||||
Gstm3 | Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (225 aa) | ||||
Gpx1 | Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family. (200 aa) | ||||
LOC102556148 | N-acetyltransferase 8 (GCN5-related) family member 4. (226 aa) | ||||
Mgst2 | Microsomal glutathione S-transferase 2. (128 aa) | ||||
Gsr | Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (417 aa) | ||||
Gpx5 | Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (220 aa) | ||||
Anpep | Aminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] (965 aa) | ||||
Gpx6 | Glutathione peroxidase 6. (220 aa) | ||||
Gstm6l | Glutathione S-transferase, mu 6-like. (215 aa) | ||||
Gstt2 | Glutathione S-transferase theta-2; Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols. Highest activity towards ethacrynic acid and cumene hydroperoxide. (244 aa) | ||||
Gpx2 | Glutathione peroxidase 2; Belongs to the glutathione peroxidase family. (189 aa) | ||||
LOC103690120 | Probable N-acetyltransferase CML1; May play a role in regulation of gastrulation. Belongs to the camello family. (231 aa) | ||||
Gstm2 | Glutathione S-transferase Yb-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (218 aa) | ||||
Gpx3 | Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (225 aa) | ||||
Rrm2 | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity); Belongs to the ribonucleoside diphosphate reductase small chain family. (390 aa) | ||||
Oplah | 5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate; Belongs to the oxoprolinase family. (1288 aa) | ||||
G6pd | Glucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. (515 aa) | ||||
Gsta4 | Glutathione S-transferase alpha-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa) | ||||
Ggt5 | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). (109 aa) | ||||
Gpx4 | Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] (253 aa) |