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Gstt1 Gstt1 Chac2 Chac2 Lap3 Lap3 Mgst3 Mgst3 Odc1 Odc1 Hpgds Hpgds Sms Sms Mgst1 Mgst1 Txndc12 Txndc12 Gpx7 Gpx7 Gpx8 Gpx8 Srm Srm Gsto1 Gsto1 Gsto2 Gsto2 Gsta1 Gsta1 Gclm Gclm Idh2 Idh2 Chac1 Chac1 Idh1 Idh1 Nat8f3 Nat8f3 Gstk1 Gstk1 Gstp1 Gstp1 Ggt7 Ggt7 Gss Gss Gstm6 Gstm6 Gstm3l Gstm3l Gstm4 Gstm4 RGD1562107 RGD1562107 Prdx6 Prdx6 Gsta6 Gsta6 RGD1562036 RGD1562036 Gclc Gclc Rrm2b Rrm2b Gstm1 Gstm1 Ggt6 Ggt6 Gsta2 Gsta2 Ggct Ggct Gstt3 Gstt3 Gstt4 Gstt4 Nat8f5 Nat8f5 Rrm1 Rrm1 LOC100910829 LOC100910829 Gstm3 Gstm3 Gpx1 Gpx1 LOC102556148 LOC102556148 Mgst2 Mgst2 Gsr Gsr Gpx5 Gpx5 Anpep Anpep Gpx6 Gpx6 Gstm6l Gstm6l Gstt2 Gstt2 Gpx2 Gpx2 LOC103690120 LOC103690120 Gstm2 Gstm2 Gpx3 Gpx3 Rrm2 Rrm2 Oplah Oplah G6pd G6pd Gsta4 Gsta4 Ggt5 Ggt5 Gpx4 Gpx4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gstt1Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Also binds steroids, bilirubin, carcinogens and numerous organic anions. Has dichloromethane dehalogenase activity. (240 aa)
Chac2Putative glutathione-specific gamma-glutamylcyclotransferase 2; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily. (178 aa)
Lap3Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). (519 aa)
Mgst3Microsomal glutathione S-transferase 3. (152 aa)
Odc1Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Belongs to the Orn/Lys/Arg decarboxylase class-II family. (461 aa)
HpgdsHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Belongs to the GST superfamily. Sigma family. (199 aa)
SmsSpermine synthase. (366 aa)
Mgst1Microsomal glutathione S-transferase 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (155 aa)
Txndc12Thioredoxin domain-containing protein 12; Possesses significant protein thiol-disulfide oxidase activity. (170 aa)
Gpx7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
Gpx8Glutathione peroxidase; Belongs to the glutathione peroxidase family. (209 aa)
SrmSpermidine synthase; Belongs to the spermidine/spermine synthase family. (302 aa)
Gsto1Glutathione S-transferase omega-1; Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family. (241 aa)
Gsto2Glutathione S-transferase omega-2; Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). Belongs to the GST superfamily. Omega family. (248 aa)
Gsta1Glutathione S-transferase alpha-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has substantial activity toward aflatoxin B1-8,9-epoxide. (221 aa)
GclmGlutamate--cysteine ligase regulatory subunit. (274 aa)
Idh2Isocitrate dehydrogenase [NADP], mitochondrial; Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex (By similarity). (452 aa)
Chac1Glutathione-specific gamma-glutamylcyclotransferase 1; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Not [...] (222 aa)
Idh1Isocitrate dehydrogenase [NADP] cytoplasmic. (414 aa)
Nat8f3N-acetyltransferase family 8 member 3; Has histone acetyltransferase activity in vitro, with specificity for histone H4. (228 aa)
Gstk1Glutathione S-transferase kappa 1; Might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment; Belongs to the GST superfamily. Kappa family. (226 aa)
Gstp1Glutathione S-transferase P; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). (210 aa)
Ggt7Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. (662 aa)
GssGlutathione synthetase; Belongs to the eukaryotic GSH synthase family. (474 aa)
Gstm6Glutathione S-transferase. (218 aa)
Gstm3lGlutathione S-transferase. (218 aa)
Gstm4Glutathione S-transferase. (218 aa)
RGD1562107Similar to class-alpha glutathione S-transferase. (222 aa)
Prdx6Peroxiredoxin-6; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role [...] (224 aa)
Gsta6Glutathione S-transferase A6; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
RGD1562036Similar to ornithine decarboxylase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (425 aa)
GclcGlutamate--cysteine ligase catalytic subunit. (637 aa)
Rrm2bRibonucleotide reductase regulatory TP53-inducible subunit M2B. (351 aa)
Gstm1Glutathione S-transferase Mu 1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. The olfactory GST may be crucial for the acuity of the olfactory process. (216 aa)
Ggt6Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates. (498 aa)
Gsta2Glutathione S-transferase alpha-2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (222 aa)
GgctGamma-glutamyl cyclotransferase. (188 aa)
Gstt3Similar to Glutathione S-transferase, theta 3 (Predicted); Belongs to the GST superfamily. (210 aa)
Gstt4Glutathione S-transferase theta-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Belongs to the GST superfamily. Theta family. (240 aa)
Nat8f5Probable N-acetyltransferase CML5; May play a role in regulation of gastrulation. Belongs to the camello family. (227 aa)
Rrm1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (792 aa)
LOC100910829N-acetyltransferase family 8 member 2; Probable acetyltransferase (Probable). Has no detectable histone acetyltransferase activity towards histone H3 or H4. Belongs to the camello family. (226 aa)
Gstm3Glutathione S-transferase Mu 5; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (225 aa)
Gpx1Glutathione peroxidase 1; Protects the hemoglobin in erythrocytes from oxidative breakdown; Belongs to the glutathione peroxidase family. (200 aa)
LOC102556148N-acetyltransferase 8 (GCN5-related) family member 4. (226 aa)
Mgst2Microsomal glutathione S-transferase 2. (128 aa)
GsrGlutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (417 aa)
Gpx5Epididymal secretory glutathione peroxidase; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids. (220 aa)
AnpepAminopeptidase N; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding [...] (965 aa)
Gpx6Glutathione peroxidase 6. (220 aa)
Gstm6lGlutathione S-transferase, mu 6-like. (215 aa)
Gstt2Glutathione S-transferase theta-2; Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols. Highest activity towards ethacrynic acid and cumene hydroperoxide. (244 aa)
Gpx2Glutathione peroxidase 2; Belongs to the glutathione peroxidase family. (189 aa)
LOC103690120Probable N-acetyltransferase CML1; May play a role in regulation of gastrulation. Belongs to the camello family. (231 aa)
Gstm2Glutathione S-transferase Yb-3; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (218 aa)
Gpx3Glutathione peroxidase 3; Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. (225 aa)
Rrm2Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). Inhibits Wnt signaling (By similarity); Belongs to the ribonucleoside diphosphate reductase small chain family. (390 aa)
Oplah5-oxoprolinase; Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate; Belongs to the oxoprolinase family. (1288 aa)
G6pdGlucose-6-phosphate 1-dehydrogenase; Cytosolic glucose-6-phosphate dehydrogenase that catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes. (515 aa)
Gsta4Glutathione S-transferase alpha-4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
Ggt5Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). (109 aa)
Gpx4Phospholipid hydroperoxide glutathione peroxidase; Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation. Required to prevent cells from ferroptosis, a non- apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). T [...] (253 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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