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Alg3 Alg3 Mgat4b Mgat4b B4galt3 B4galt3 Mgat4d Mgat4d Mgat2 Mgat2 Alg2 Alg2 Fut8 Fut8 Dad1 Dad1 Hexa Hexa Alg14 Alg14 Man1b1 Man1b1 Alg11 Alg11 Stt3b Stt3b Tusc3 Tusc3 Man2a1 Man2a1 Chst9 Chst9 Man1c1 Man1c1 Mgat4a Mgat4a B4galt2 B4galt2 Chst8 Chst8 B4galnt3 B4galnt3 Alg9 Alg9 Hexd Hexd St3gal3 St3gal3 Alg1 Alg1 Man1a2 Man1a2 Alg12 Alg12 Ddost Ddost Rpn2 Rpn2 Rpn1 Rpn1 Alg13 Alg13 Mgat1 Mgat1 B4galnt4 B4galnt4 Man1a1 Man1a1 B4galt1 B4galt1 Man2a2 Man2a2 Chek1 Chek1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Alg3Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol. (438 aa)
Mgat4bSimilar to N-acetylglucosaminyltrasnferase IVb (Predicted), isoform CRA_b. (548 aa)
B4galt3Beta-1,4-galactosyltransferase 3; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids; Belongs to the glycosyltransferase 7 family. (395 aa)
Mgat4dAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis; Belongs to the glycosyltransferase 54 family. (372 aa)
Mgat2Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. (442 aa)
Alg2Asparagine-linked glycosylation 2 homolog (Yeast, alpha-1,3-mannosyltransferase), isoform CRA_a. (415 aa)
Fut8Alpha-(1,6)-fucosyltransferase; Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. (575 aa)
Dad1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (113 aa)
HexaBeta-hexosaminidase subunit alpha; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (528 aa)
Alg14UDP-N-acetylglucosamine transferase subunit ALG14 homolog; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity). (216 aa)
Man1b1Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase; Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2) (By similarity); Belongs to the glycosyl hydrolase 47 family. (657 aa)
Alg11ALG11, alpha-1,2-mannosyltransferase. (430 aa)
Stt3bSTT3 oligosaccharyltransferase complex catalytic subunit B. (824 aa)
Tusc3Tumor suppressor candidate 3, isoform CRA_b. (347 aa)
Man2a1Alpha-mannosidase 2; Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N- glycans; the final hydrolytic step in the N-glycan maturation pathway. (1148 aa)
Chst9Carbohydrate sulfotransferase. (414 aa)
Man1c1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (625 aa)
Mgat4aAlpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By sim [...] (535 aa)
B4galt2UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2 (Predicted). (369 aa)
Chst8Carbohydrate sulfotransferase. (417 aa)
B4galnt3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (989 aa)
Alg9Mannosyltransferase. (429 aa)
HexdHexosaminidase D. (486 aa)
St3gal3CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase soluble form; Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta-1,4- GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-alpha-2,3-Gal- beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta- 1,3-GlcNAc and the lowest toward Gal-beta-1,3-GalNAc. Belongs to the glycosyltransferase 29 family. (374 aa)
Alg1Asparagine-linked glycosylation 1 homolog (Yeast, beta-1,4-mannosyltransferase) (Predicted). (303 aa)
Man1a2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (640 aa)
Alg12Mannosyltransferase. (488 aa)
DdostDolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (441 aa)
Rpn2Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (631 aa)
Rpn1Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (606 aa)
Alg13UDP-N-acetylglucosamine transferase subunit ALG13 homolog; May be involved in protein N-glycosylation, second step of the dolichol-linked oligosaccharide pathway; Belongs to the glycosyltransferase 28 family. (165 aa)
Mgat1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans. (447 aa)
B4galnt4Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1033 aa)
Man1a1alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (746 aa)
B4galt1UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 1 (Mapped), isoform CRA_a. (399 aa)
Man2a2Alpha-mannosidase. (1181 aa)
Chek1Serine/threonine-protein kinase Chk1. (773 aa)
Your Current Organism:
Rattus norvegicus
NCBI taxonomy Id: 10116
Other names: Buffalo rat, Norway rat, R. norvegicus, Rattus PC12 clone IS, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats
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