Your Input: | |||||
| Plpp2 | Phospholipid phosphatase 2; Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N- (9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioacti [...] (276 aa) | ||||
| Agpat1 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (284 aa) | ||||
| Pla2g1b | Phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (146 aa) | ||||
| Agpat3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 (Predicted), isoform CRA_b. (376 aa) | ||||
| Pcyt1a | Choline-phosphate cytidylyltransferase A; Controls phosphatidylcholine synthesis; Belongs to the cytidylyltransferase family. (367 aa) | ||||
| Dgkg | Diacylglycerol kinase gamma; Belongs to the eukaryotic diacylglycerol kinase family. (788 aa) | ||||
| Cds1 | Phosphatidate cytidylyltransferase 1; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (By similarity). May play an important role in phosphoinositide synthesis, prefers 1- stearoyl-2-arachidonoyl phosphatidic acid as substrate; Belongs to the CDS family. (461 aa) | ||||
| Gpat3 | Glycerol-3-phosphate acyltransferase 3; Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone (By similarity). Also converts LPA into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). (457 aa) | ||||
| Dgke | Diacylglycerol kinase. (567 aa) | ||||
| Pgs1 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin; Belongs to the CDP-alcohol phosphatidyltransferase class-II family. (510 aa) | ||||
| Pla2g10 | Group 10 secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids (By similarity). Belongs to the phospholipase A2 family. (151 aa) | ||||
| Adprm | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP- glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. (337 aa) | ||||
| Lpin1 | RCG61514, isoform CRA_a. (924 aa) | ||||
| Lpcat4 | Lysophosphatidylcholine acyltransferase 4. (522 aa) | ||||
| Phospho1 | Phosphoethanolamine/phosphocholine phosphatase 1. (289 aa) | ||||
| Pla2g4f | Phospholipase A2. (733 aa) | ||||
| Plpp3 | Phospholipid phosphatase 3; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z- octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Has both an extracellular and an intracellular phosphatase activity, allowing the hydrolysis and the cellular uptake of the [...] (312 aa) | ||||
| Lypla1 | Acyl-protein thioesterase 1; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity toward KCNMA1. Has low lysophospholipase activity (By similarity). (230 aa) | ||||
| Pnpla7 | Patatin-like phospholipase domain-containing protein 7; Serine hydrolase, whose specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. (1349 aa) | ||||
| Cdipt | CDP-diacylglycerol--inositol 3-phosphatidyltransferase; Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (213 aa) | ||||
| Lypla2 | Acyl-protein thioesterase 2; Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GAP43, ZDHHC6 or HRAS. Deacylates GAP43. Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (By similarity). (231 aa) | ||||
| Chkb | Choline/ethanolamine kinase; Has a key role in phospholipid metabolism, and catalyzes the first step of phosphatidylethanolamine and phosphatidylcholine biosynthesis. (394 aa) | ||||
| Pcyt1b | Choline-phosphate cytidylyltransferase B; Controls phosphatidylcholine synthesis. (369 aa) | ||||
| Lpcat3 | Lysophospholipid acyltransferase 5; Seems to be the major enzyme contributing to lysophosphatidylcholine acyltransferase activity in the liver. Favors unsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Displays lysophosphatidylserine acyltransferase (LPSAT) activity (By similarity). (487 aa) | ||||
| Gpat2 | Glycerol-3-phosphate acyltransferase 2, mitochondrial. (801 aa) | ||||
| Etnk1 | Ethanolamine kinase 1 (Predicted). (363 aa) | ||||
| Plpp5 | Phospholipid phosphatase 5. (260 aa) | ||||
| Ptdss2 | Phosphatidylserine synthase 2; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity); Belongs to the phosphatidyl serine synthase family. (471 aa) | ||||
| Lpcat2 | Lysophosphatidylcholine acyltransferase 2; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, ac [...] (544 aa) | ||||
| Lpin3 | RCG32184. (844 aa) | ||||
| Pla2g2f | Phospholipase A(2). (210 aa) | ||||
| Pla2g2d | Phospholipase A(2). (144 aa) | ||||
| Pla2g5 | Calcium-dependent phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes L-alpha- palmitoyl-2-oleoyl phosphatidylcholine more efficiently than L-alpha-1- palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2- arachidonyl phosphatidylethanolamine or L-alpha-1-stearoyl-2- arachidonyl phosphatidylinositol. (137 aa) | ||||
| Pla2g2a | Phospholipase A2, membrane associated; Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Acts as a ligand for integrins. Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1. Independent of its catalytic activity, activates integrins by binding to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and inducing integrin conformational changes and enhanced ligand binding to site [...] (146 aa) | ||||
| Chka | Choline kinase alpha; Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline (By similarity). (453 aa) | ||||
| Lpcat1 | Lysophosphatidylcholine acyltransferase 1; Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-independent (By similarity). Mediates the conversion of 1-acyl-sn-glycero-3- phosphocholine (LPC) into phosphatidylcholine (PC). Displays a clear preference for saturated fatty acyl-CoAs, and 1- myristoyl or 1-palmitoyl LPC as acyl donors and acceptors, respectively. May synthesize phosphatidylcholine in pulmonary surfactant, thereby playing a pivotal role in respiratory physiology. Involved in the regulation of lipid droplet number and size (By similarity). (534 aa) | ||||
| Dgkz | Diacylglycerol kinase zeta; Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity). Positively regulates insulin-induced translocation of SLC2A4 to the cell membrane in adipocytes (By similarity). Activates PIP5K1A activity via generation of phosphatidic acid (By similarity). (929 aa) | ||||
| Gpat4 | 1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta). (456 aa) | ||||
| Pisd | Phosphatidylserine decarboxylase proenzyme, mitochondrial; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine. (406 aa) | ||||
| Agpat2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (265 aa) | ||||
| Lcat | Phosphatidylcholine-sterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and influences cerebral spinal [...] (440 aa) | ||||
| Gnpat | Dihydroxyacetone phosphate acyltransferase. (678 aa) | ||||
| Pla2g15 | Group XV phospholipase A2; Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity); Belongs to the AB hydrolase superfamily. Lipase family. (413 aa) | ||||
| Plpp4 | Phospholipid phosphatase 4. (271 aa) | ||||
| Cds2 | Phosphatidate cytidylyltransferase 2; Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin; Belongs to the CDS family. (444 aa) | ||||
| Crls1 | Cardiolipin synthase (CMP-forming); Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (302 aa) | ||||
| Dgkd | Diacylglycerol kinase. (1162 aa) | ||||
| Pla2g4e | Phospholipase A2. (828 aa) | ||||
| Pla2g3 | Phospholipase A2, group III (Predicted), isoform CRA_a. (506 aa) | ||||
| Pld4 | Similar to phospholipase D family, member 4. (529 aa) | ||||
| Cept1 | Choline/ethanolaminephosphotransferase 1; Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP- ethanolamine, respectively. Involved in protein-dependent process of phospholipid transport to distribute phosphatidyl choline to the lumenal surface. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity (By similarity). (416 aa) | ||||
| Dgki | Diacylglycerol kinase. (1050 aa) | ||||
| Mboat1 | Membrane-bound O-acyltransferase domain-containing 1; Belongs to the membrane-bound acyltransferase family. (492 aa) | ||||
| Gpd1l | Glycerol-3-phosphate dehydrogenase [NAD(+)]. (351 aa) | ||||
| Dgkq | Diacylglycerol kinase. (937 aa) | ||||
| Agpat5 | 1-acylglycerol-3-phosphate O-acyltransferase 5. (359 aa) | ||||
| Plaat3 | Phospholipase A and acyltransferase 3; Exhibits both phospholipase A1/2 and acyltransferase activities. Shows phospholipase A1 (PLA1) and A2 (PLA2), ccatalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids. For most substrates, PLA1 activity is much higher than PLA2 activity (By similarity). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer o [...] (160 aa) | ||||
| Dgka | Diacylglycerol kinase alpha; Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity. (727 aa) | ||||
| Gpd2 | Glycerol-3-phosphate dehydrogenase, mitochondrial. (726 aa) | ||||
| Lclat1 | Similar to lysocardiolipin acyltransferase isoform 1 (Predicted). (376 aa) | ||||
| Pcyt2 | Ethanolamine-phosphate cytidylyltransferase; Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP- ethanolamine (By similarity); Belongs to the cytidylyltransferase family. (404 aa) | ||||
| Pla2g4d | Phospholipase A2. (825 aa) | ||||
| Pld2 | Phospholipase D2; May have a role in signal-induced cytoskeletal regulation and/or endocytosis; Belongs to the phospholipase D family. (931 aa) | ||||
| Pld3 | 5'-3' exonuclease PLD3; 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (By similarity). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4 (By similarity). May be important in myotube formation. Plays a role in lysosomal homeostasis. Involved in the regulation of endosomal protein sorting (By similarity). (488 aa) | ||||
| Dgkh | Diacylglycerol kinase. (1210 aa) | ||||
| Pla2g4c | Phospholipase A2 group IVC. (604 aa) | ||||
| Dgkk | Diacylglycerol kinase. (1081 aa) | ||||
| Plb1 | Phospholipase B1, membrane-associated; Membrane-associated phospholipase. Exhibits a calcium- independent broad substrate specificity including phospholipase A2/lysophospholipase activity. Preferential hydrolysis at the sn-2 position of diacylphospholipids and diacyglycerol, whereas it shows no positional specificity toward triacylglycerol. Exhibits also esterase activity toward p-nitrophenyl. May act on the brush border membrane to facilitate the absorption of digested lipids. Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily. (1111 aa) | ||||
| Dgkb | Diacylglycerol kinase beta; Exhibits high phosphorylation activity for long-chain diacylglycerols. (802 aa) | ||||
| Pla2g4b | Phospholipase A2. (791 aa) | ||||
| Etnk2 | Ethanolamine kinase 2; Highly specific for ethanolamine phosphorylation. Does not have choline kinase activity. (191 aa) | ||||
| Lpgat1 | Lysophosphatidylglycerol acyltransferase 1. (370 aa) | ||||
| Pnpla6 | Patatin-like phospholipase domain-containing 6. (1354 aa) | ||||
| Etnppl | Ethanolamine-phosphate phospho-lyase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (499 aa) | ||||
| Pla2g12b | Phospholipase A2, group XIIB. (195 aa) | ||||
| Gpam | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (828 aa) | ||||
| Mboat7l1 | Membrane-bound O-acyltransferase domain-containing 7-like 1; Belongs to the membrane-bound acyltransferase family. (473 aa) | ||||
| Agpat4 | 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity). (414 aa) | ||||
| Lpin2 | Lipin 2. (932 aa) | ||||
| Chat | Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses. (644 aa) | ||||
| Ptdss1 | Phosphatidylserine synthase 1; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. In membranes, PTDSS1 catalyzes mainly the conversion of phosphatidylcholine. Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (By similarity). (502 aa) | ||||
| Taz | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (262 aa) | ||||
| Pla1a | Phospholipase A1 member A; Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1-acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production. (456 aa) | ||||
| Chpt1 | Cholinephosphotransferase 1; Catalyzes phosphatidylcholine biosynthesis from CDP-choline. It thereby plays a central role in the formation and maintenance of vesicular membranes (By similarity). (398 aa) | ||||
| Pla2g2c | Group IIC secretory phospholipase A2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides; Belongs to the phospholipase A2 family. (158 aa) | ||||
| Selenoi | Selenoprotein I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (394 aa) | ||||
| Pld1 | Phospholipase D1; Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity). (1077 aa) | ||||
| Pla2g12a | Phospholipase A2, group XIIA. (192 aa) | ||||
| Ache | Acetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft; Belongs to the type-B carboxylesterase/lipase family. (614 aa) | ||||
| Lpcat2b | Lysophosphatidylcholine acyltransferase 2B; Probable acetyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (517 aa) | ||||
| Gpd1 | Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic. (349 aa) | ||||
| Pemt | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC). (199 aa) | ||||
| Gpcpd1 | Glycerophosphocholine phosphodiesterase GPCPD1; May be involved in the negative regulation of skeletal muscle differentiation, independently of its glycerophosphocholine phosphodiesterase activity. (671 aa) | ||||
| Mboat2 | Membrane-bound O-acyltransferase domain-containing protein 2; Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. (519 aa) | ||||
| Pla2g4a | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (752 aa) | ||||