(20 nodes) Mixed, incl. SCF-beta-TrCP mediated degradation of Emi1, and SCF complex assembly network (Cavia porcellus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FBXO9	F-box protein 9. (438 aa)
	CAND1	Cullin associated and neddylation dissociated 1. (1230 aa)
	FBXO43	F-box protein 43. (622 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (410 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] (162 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (582 aa)
	FBXW9	F-box and WD repeat domain containing 9. (457 aa)
	KDM2A	Lysine demethylase 2A. (1161 aa)
	CACUL1	CDK2 associated cullin domain 1. (350 aa)
	WDR86	WD repeat domain 86. (374 aa)
	CAND2	Cullin associated and neddylation dissociated 2 (putative). (1236 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (300 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	FBXW2	F-box and WD repeat domain containing 2. (454 aa)
	RBX1	Ring-box 1. (108 aa)
	FBXW7	F-box and WD repeat domain containing 7. (711 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (674 aa)
	ENSCPOP00000027611	Uncharacterized protein. (421 aa)
	ENSCPOP00000029251	Uncharacterized protein; Belongs to the SKP1 family. (147 aa)
	FBXW11	F-box and WD repeat domain containing 11. (530 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTRC	CACUL1	ENSCPOP00000004942	ENSCPOP00000009795	Beta-transducin repeat containing E3 ubiquitin protein ligase.	CDK2 associated cullin domain 1.	0.905
BTRC	CAND1	ENSCPOP00000004942	ENSCPOP00000001620	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin associated and neddylation dissociated 1.	0.585
BTRC	CAND2	ENSCPOP00000004942	ENSCPOP00000015824	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin associated and neddylation dissociated 2 (putative).	0.554
BTRC	CCNE1	ENSCPOP00000004942	ENSCPOP00000004351	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cyclin E1; Belongs to the cyclin family.	0.401
BTRC	CUL1	ENSCPOP00000004942	ENSCPOP00000016460	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1; Belongs to the cullin family.	0.999
BTRC	ENSCPOP00000027611	ENSCPOP00000004942	ENSCPOP00000027611	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Uncharacterized protein.	0.867
BTRC	ENSCPOP00000029251	ENSCPOP00000004942	ENSCPOP00000029251	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Uncharacterized protein; Belongs to the SKP1 family.	0.986
BTRC	FBXL15	ENSCPOP00000004942	ENSCPOP00000015935	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine rich repeat protein 15.	0.455
BTRC	FBXL19	ENSCPOP00000004942	ENSCPOP00000026753	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and leucine rich repeat protein 19.	0.400
BTRC	FBXO43	ENSCPOP00000004942	ENSCPOP00000001957	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 43.	0.816
BTRC	FBXW11	ENSCPOP00000004942	ENSCPOP00000031139	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.960
BTRC	FBXW2	ENSCPOP00000004942	ENSCPOP00000022609	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 2.	0.650
BTRC	FBXW7	ENSCPOP00000004942	ENSCPOP00000026551	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 7.	0.899
BTRC	FBXW9	ENSCPOP00000004942	ENSCPOP00000006337	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 9.	0.799
BTRC	KDM2A	ENSCPOP00000004942	ENSCPOP00000006433	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Lysine demethylase 2A.	0.443
BTRC	RBX1	ENSCPOP00000004942	ENSCPOP00000025414	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Ring-box 1.	0.995
BTRC	SKP1	ENSCPOP00000004942	ENSCPOP00000004645	Beta-transducin repeat containing E3 ubiquitin protein ligase.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...]	0.989
BTRC	WDR86	ENSCPOP00000004942	ENSCPOP00000015356	Beta-transducin repeat containing E3 ubiquitin protein ligase.	WD repeat domain 86.	0.675
CACUL1	BTRC	ENSCPOP00000009795	ENSCPOP00000004942	CDK2 associated cullin domain 1.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.905
CACUL1	CAND1	ENSCPOP00000009795	ENSCPOP00000001620	CDK2 associated cullin domain 1.	Cullin associated and neddylation dissociated 1.	0.914