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| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | EXO1 | Exonuclease 1. (839 aa) |
| | ATRIP | ATR interacting protein. (792 aa) |
| | PMS2 | PMS1 homolog 2, mismatch repair system component. (890 aa) |
| | SASS6 | SAS-6 centriolar assembly protein. (590 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (280 aa) |
| | RAD17 | RAD17 checkpoint clamp loader component. (696 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (810 aa) |
| | Msh5 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (828 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa) |
| | POLK | DNA polymerase kappa. (540 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (884 aa) |
| | DUSP12 | Dual specificity phosphatase 12. (338 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1059 aa) |
| | FANCM | FA complementation group M. (1971 aa) |
| | MEIOB | Meiosis specific with OB-fold. (471 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (263 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | FAAP100 | FA core complex associated protein 100. (856 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | Pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | Rad50 | Zinc-hook domain-containing protein. (1275 aa) |
| | FANCA | FA complementation group A. (1416 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (502 aa) |
| | DCLRE1C | DNA cross-link repair 1C. (688 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1118 aa) |
| | APLF | Aprataxin and PNKP like factor. (498 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (609 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ORC6 | Origin recognition complex subunit 6. (293 aa) |
| | PRIM2 | DNA primase subunit 2. (432 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | Lig1 | DNA ligase. (909 aa) |
| | RFC1 | Replication factor C subunit 1. (1153 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | RAD51C | RAD51 paralog C. (373 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3151 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa) |
| | FANCE | FA complementation group E. (531 aa) |
| | FANCD2 | FA complementation group D2. (1448 aa) |
| | SPAG7 | Sperm-associated antigen 7. (227 aa) |
| | NEIL2 | Nei like DNA glycosylase 2. (336 aa) |
| | CHEK2 | Checkpoint kinase 2. (546 aa) |
| | TDP2 | Tyrosyl-DNA phosphodiesterase 2. (358 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | FANCI | FA complementation group I. (1313 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (657 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (834 aa) |
| | RBPMS2 | RNA binding protein, mRNA processing factor 2. (178 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (562 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa) |
| | DBF4 | DBF4 zinc finger. (675 aa) |
| | KREMEN2 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (462 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (303 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (643 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (794 aa) |
| | SLC23A3 | Solute carrier family 23 member 3. (601 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | CHTF18 | Chromosome transmission fidelity factor 18. (988 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (898 aa) |
| | RMI1 | RecQ mediated genome instability 1. (617 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (205 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa) |
| | TDRD3 | Tudor domain containing 3. (692 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa) |
| | FBH1 | F-box DNA helicase 1. (1012 aa) |
| | RAD51B | RAD51 paralog B. (258 aa) |
| | NEIL1 | Nei like DNA glycosylase 1. (401 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | MSH3 | MutS homolog 3. (1047 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (662 aa) |
| | Clspn | Uncharacterized protein. (1330 aa) |
| | BRIP1 | BRCA1 interacting protein C-terminal helicase 1. (971 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1831 aa) |
| | FAAP24 | FA core complex associated protein 24. (215 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | FANCG | FA complementation group G. (626 aa) |
| | TDP1 | Tyrosyl-DNA phosphodiesterase 1. (607 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (280 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | Mutyh | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa) |
| | CDC7 | Cell division cycle 7. (560 aa) |
| | LIG3 | DNA ligase. (1012 aa) |
| | MND1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (200 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (987 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | HELB | DNA helicase B. (1063 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | DCLRE1A | DNA cross-link repair 1A. (913 aa) |
| | DMC1 | Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (340 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (485 aa) |
| | H0VSI3_CAVPO | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa) |
| | ORC3 | Origin recognition complex subunit 3. (710 aa) |
| | MCPH1 | Uncharacterized protein. (786 aa) |
| | FANCL | FA complementation group L. (355 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | Prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | FANCF | FA complementation group F. (322 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (338 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | RAD9B | Cell cycle checkpoint control protein; Belongs to the rad9 family. (401 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | PAXX | PAXX non-homologous end joining factor. (206 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | PSMC3IP | PSMC3 interacting protein. (217 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (731 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (2940 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (549 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (299 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (578 aa) |
| | Slx1a | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (266 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (282 aa) |
| | MLH3 | MutL homolog 3. (1455 aa) |
| | UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (208 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | Bivm | Uncharacterized protein. (503 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1738 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (916 aa) |
| | Cenpx | Uncharacterized protein. (79 aa) |
| | PMS1 | PMS1 homolog 1, mismatch repair system component. (930 aa) |
| | TIMELESS | Timeless circadian regulator. (1239 aa) |
| | ORC5 | Origin recognition complex subunit 5. (414 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (384 aa) |
| | ANKRD12 | Ankyrin repeat domain 12. (2046 aa) |
| | UNG-2 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (739 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | Tm4sf19 | Uncharacterized protein. (232 aa) |
| | LOC100717396 | Uncharacterized protein. (1249 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1392 aa) |
| | Mcm8 | MCM domain-containing protein; Belongs to the MCM family. (833 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (371 aa) |
| | MPG | N-methylpurine DNA glycosylase. (300 aa) |
| | Rchy1 | Uncharacterized protein. (171 aa) |
| | APTX | Aprataxin. (341 aa) |
| | PWWP2A | PWWP domain containing 2A. (722 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | NUTF2 | Nuclear transport factor 2. (127 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (334 aa) |
| | POLI | DNA polymerase iota. (662 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (2499 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) |
| | CNPPD1 | Cyclin Pas1/PHO80 domain containing 1. (409 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (629 aa) |
| | RAD51D | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents; Belongs to the RecA family. RAD51 subfamily. (329 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (569 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (333 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1027 aa) |
