STRINGSTRING
DCLRE1C DCLRE1C APLF APLF XRCC6 XRCC6 Lig1 Lig1 POLL POLL NEIL2 NEIL2 TDP2 TDP2 TOP1 TOP1 SLC23A3 SLC23A3 POLB POLB NEIL1 NEIL1 TDP1 TDP1 LIG3 LIG3 PRKDC PRKDC LIG4 LIG4 POLM POLM PAXX PAXX NHEJ1 NHEJ1 XRCC5 XRCC5 APTX APTX CNPPD1 CNPPD1 XRCC1 XRCC1 XRCC4 XRCC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DCLRE1CDNA cross-link repair 1C. (688 aa)
APLFAprataxin and PNKP like factor. (498 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
Lig1DNA ligase. (909 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
NEIL2Nei like DNA glycosylase 2. (336 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (358 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
SLC23A3Solute carrier family 23 member 3. (601 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
NEIL1Nei like DNA glycosylase 1. (401 aa)
TDP1Tyrosyl-DNA phosphodiesterase 1. (607 aa)
LIG3DNA ligase. (1012 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa)
LIG4DNA ligase. (911 aa)
POLMDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (485 aa)
PAXXPAXX non-homologous end joining factor. (206 aa)
NHEJ1Non-homologous end joining factor 1. (299 aa)
XRCC5X-ray repair cross complementing 5. (739 aa)
APTXAprataxin. (341 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (409 aa)
XRCC1X-ray repair cross complementing 1. (629 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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