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NECAP1 NECAP1 AP3B1 AP3B1 ITSN1 ITSN1 AP1G2 AP1G2 REPS1 REPS1 DNM3 DNM3 CBLC CBLC GGA3 GGA3 AP4B1 AP4B1 SNAP91 SNAP91 TBC1D8B TBC1D8B TBC1D16 TBC1D16 RABEP2 RABEP2 AP3M2 AP3M2 H0UZN0_CAVPO H0UZN0_CAVPO AP5M1 AP5M1 REPS2 REPS2 AP1M1 AP1M1 NECAP2 NECAP2 SH3GL3 SH3GL3 SH3GLB2 SH3GLB2 AP3D1 AP3D1 SYNRG SYNRG AAK1 AAK1 RAB21 RAB21 EPN2 EPN2 AP3M1 AP3M1 AP2A1 AP2A1 AP4M1 AP4M1 AP4S1 AP4S1 RAB5A RAB5A CLTC CLTC CTTN CTTN DNMBP DNMBP AP4E1 AP4E1 HCLS1 HCLS1 RUFY2 RUFY2 SH3KBP1 SH3KBP1 AMPH AMPH RUFY3 RUFY3 ANKFY1 ANKFY1 HIP1 HIP1 HIP1R HIP1R H0VBH1_CAVPO H0VBH1_CAVPO RAB22A RAB22A TOM1 TOM1 Dab2 Dab2 DNAJC6 DNAJC6 Epn1 Epn1 H0VDM4_CAVPO H0VDM4_CAVPO RABGAP1 RABGAP1 Ap2b1 Ap2b1 FCHO1 FCHO1 CD2AP CD2AP SHTN1 SHTN1 BIN3 BIN3 AP2A2 AP2A2 Rab5c Rab5c AP5B1 AP5B1 RINL RINL AP3B2 AP3B2 BMP2K BMP2K FAM214B FAM214B SGIP1 SGIP1 RUFY1 RUFY1 TBRG4 TBRG4 IGF2R IGF2R ITSN2 ITSN2 AP1S1 AP1S1 AP5Z1 AP5Z1 ENTHD1 ENTHD1 ALS2 ALS2 RAB32 RAB32 EEA1 EEA1 NET1 NET1 RABGAP1L RABGAP1L SGSM2 SGSM2 RAB17 RAB17 SORL1 SORL1 SH3GL2 SH3GL2 H0VY49_CAVPO H0VY49_CAVPO VGF VGF TOM1L1 TOM1L1 EPN3 EPN3 AP1S2 AP1S2 AP2S1 AP2S1 SH3GL1 SH3GL1 GGA1 GGA1 AP3S2 AP3S2 BIN1 BIN1 LOC100718000 LOC100718000 ALS2CL ALS2CL Zfand5 Zfand5 RAB24 RAB24 RAB5B RAB5B TOLLIP TOLLIP ARL8B ARL8B AP3S1 AP3S1 GGA2 GGA2 AP2M1 AP2M1 ZFYVE26 ZFYVE26 PICALM PICALM GAS7 GAS7 Tgoln2 Tgoln2 HTT HTT TOM1L2 TOM1L2 EPS15L1 EPS15L1 CLTCL1 CLTCL1 ARF3 ARF3 GAK GAK TRAM2 TRAM2 AP1G1 AP1G1 RIN2 RIN2 ENSCPOP00000026245 ENSCPOP00000026245 RAB4A RAB4A LOC100727246 LOC100727246 SORCS1 SORCS1 ENSCPOP00000026444 ENSCPOP00000026444 DNM2 DNM2 DNM1 DNM1 ANKRD27 ANKRD27 Rab4b Rab4b ENSCPOP00000027386 ENSCPOP00000027386 CLTB CLTB ENOX1 ENOX1 FCHO2 FCHO2 STON2 STON2 AP1S3 AP1S3 AP1B1 AP1B1 GAPVD1 GAPVD1 RAB31 RAB31 AGFG1 AGFG1 RAB20 RAB20 CLTA CLTA AP5S1 AP5S1 EPS15 EPS15 USP6NL USP6NL RABEP1 RABEP1 AP1M2 AP1M2 ENSCPOP00000031438 ENSCPOP00000031438 LOC100725073 LOC100725073 ZFAND6 ZFAND6 RAB38 RAB38 Rabgef1 Rabgef1 SH3GLB1 SH3GLB1 ENSCPOP00000033061 ENSCPOP00000033061
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NECAP1NECAP endocytosis associated 1. (274 aa)
AP3B1Adaptor related protein complex 3 subunit beta 1. (1276 aa)
ITSN1Intersectin 1. (1657 aa)
AP1G2AP-1 complex subunit gamma. (786 aa)
REPS1RALBP1 associated Eps domain containing 1. (787 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (811 aa)
CBLCCbl proto-oncogene C. (489 aa)
GGA3Golgi associated, gamma adaptin ear containing, ARF binding protein 3. (714 aa)
AP4B1AP complex subunit beta; Belongs to the adaptor complexes large subunit family. (722 aa)
SNAP91Synaptosome associated protein 91. (896 aa)
TBC1D8BTBC1 domain family member 8B. (1064 aa)
TBC1D16TBC1 domain family member 16. (766 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (562 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
H0UZN0_CAVPOUncharacterized protein. (763 aa)
AP5M1Adaptor related protein complex 5 subunit mu 1; Belongs to the adaptor complexes medium subunit family. (490 aa)
REPS2RALBP1 associated Eps domain containing 2. (561 aa)
AP1M1AP-1 complex subunit mu-1; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (438 aa)
NECAP2NECAP endocytosis associated 2. (266 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (346 aa)
SH3GLB2SH3 domain containing GRB2 like, endophilin B2. (398 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1161 aa)
SYNRGSynergin gamma. (1292 aa)
AAK1AP2 associated kinase 1. (957 aa)
RAB21RAB21, member RAS oncogene family. (200 aa)
EPN2Epsin 2. (646 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
AP4M1AP-4 complex subunit mu-1; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asym [...] (453 aa)
AP4S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (144 aa)
RAB5ARAB5A, member RAS oncogene family. (214 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
CTTNCortactin. (550 aa)
DNMBPDynamin binding protein. (1568 aa)
AP4E1AP-4 complex subunit epsilon; Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin- associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. (1130 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (472 aa)
RUFY2RUN and FYVE domain containing 2. (585 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (716 aa)
AMPHAmphiphysin. (680 aa)
RUFY3RUN and FYVE domain containing 3. (628 aa)
ANKFY1Ankyrin repeat and FYVE domain containing 1. (1169 aa)
HIP1Huntingtin interacting protein 1. (1024 aa)
HIP1RHuntingtin interacting protein 1 related. (1035 aa)
H0VBH1_CAVPOUncharacterized protein. (134 aa)
RAB22ARAB22A, member RAS oncogene family. (194 aa)
TOM1Target of myb1 membrane trafficking protein; Belongs to the TOM1 family. (490 aa)
Dab2PID domain-containing protein. (766 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (901 aa)
Epn1ENTH domain-containing protein. (54 aa)
H0VDM4_CAVPOTcp10_C domain-containing protein. (348 aa)
RABGAP1RAB GTPase activating protein 1. (1054 aa)
Ap2b1AP complex subunit beta. (951 aa)
FCHO1FCH domain only 1. (892 aa)
CD2APCD2 associated protein. (632 aa)
SHTN1Shootin 1. (631 aa)
BIN3Bridging integrator 3. (253 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (937 aa)
Rab5cUncharacterized protein. (216 aa)
AP5B1Adaptor related protein complex 5 subunit beta 1. (875 aa)
RINLRas and Rab interactor like. (569 aa)
AP3B2AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1086 aa)
BMP2KBMP2 inducible kinase. (1072 aa)
FAM214BFamily with sequence similarity 214 member B. (538 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (825 aa)
RUFY1RUN and FYVE domain containing 1. (694 aa)
TBRG4Transforming growth factor beta regulator 4. (631 aa)
IGF2RInsulin like growth factor 2 receptor. (2473 aa)
ITSN2Intersectin 2. (1684 aa)
AP1S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (182 aa)
AP5Z1Adaptor related protein complex 5 subunit zeta 1. (806 aa)
ENTHD1ENTH domain containing 1. (601 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1580 aa)
RAB32RAB32, member RAS oncogene family. (205 aa)
EEA1Early endosome antigen 1. (1377 aa)
NET1Neuroepithelial cell transforming 1. (597 aa)
RABGAP1LRAB GTPase activating protein 1 like. (1061 aa)
SGSM2Small G protein signaling modulator 2. (1039 aa)
RAB17RAB17, member RAS oncogene family. (208 aa)
SORL1Sortilin related receptor 1. (2211 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (376 aa)
H0VY49_CAVPOBAR domain-containing protein. (201 aa)
VGFVGF nerve growth factor inducible. (516 aa)
TOM1L1Target of myb1 like 1 membrane trafficking protein; Belongs to the TOM1 family. (478 aa)
EPN3Epsin 3. (635 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
AP2S1AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (148 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (359 aa)
GGA1Golgi associated, gamma adaptin ear containing, ARF binding protein 1. (638 aa)
AP3S2Adaptor related protein complex 3 subunit sigma 2. (193 aa)
BIN1Bridging integrator 1. (577 aa)
LOC100718000Uncharacterized protein. (350 aa)
ALS2CLALS2 C-terminal like. (990 aa)
Zfand5Uncharacterized protein. (213 aa)
RAB24RAB24, member RAS oncogene family. (203 aa)
RAB5BRAB5B, member RAS oncogene family. (215 aa)
TOLLIPToll interacting protein. (274 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
GGA2Golgi associated, gamma adaptin ear containing, ARF binding protein 2. (617 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2540 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (660 aa)
GAS7Growth arrest specific 7. (425 aa)
Tgoln2Uncharacterized protein. (323 aa)
HTTHuntingtin. (3133 aa)
TOM1L2Target of myb1 like 2 membrane trafficking protein. (551 aa)
EPS15L1Epidermal growth factor receptor pathway substrate 15 like 1. (905 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1676 aa)
ARF3ADP ribosylation factor 3; Belongs to the small GTPase superfamily. Arf family. (181 aa)
GAKCyclin G associated kinase. (1310 aa)
TRAM2Translocating chain-associated membrane protein; Belongs to the TRAM family. (370 aa)
AP1G1AP-1 complex subunit gamma. (734 aa)
RIN2Ras and Rab interactor 2. (892 aa)
ENSCPOP00000026245A20-type domain-containing protein. (179 aa)
RAB4ARAB4A, member RAS oncogene family. (218 aa)
LOC100727246Uncharacterized protein. (226 aa)
SORCS1Sortilin related VPS10 domain containing receptor 1. (1084 aa)
ENSCPOP00000026444Uncharacterized protein. (171 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (878 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
ANKRD27Ankyrin repeat domain 27. (1067 aa)
Rab4bUncharacterized protein. (213 aa)
ENSCPOP00000027386Uncharacterized protein. (234 aa)
CLTBClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
ENOX1Ecto-NOX disulfide-thiol exchanger 1. (643 aa)
FCHO2FCH domain only 2. (830 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (894 aa)
AP1S3AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (154 aa)
AP1B1AP complex subunit beta. (945 aa)
GAPVD1GTPase activating protein and VPS9 domains 1. (1460 aa)
RAB31RAB31, member RAS oncogene family. (196 aa)
AGFG1ArfGAP with FG repeats 1. (586 aa)
RAB20RAB20, member RAS oncogene family. (222 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (242 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
EPS15Epidermal growth factor receptor pathway substrate 15. (935 aa)
USP6NLUSP6 N-terminal like. (844 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (849 aa)
AP1M2AP-1 complex subunit mu-2; Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. (449 aa)
ENSCPOP00000031438annotation not available (62 aa)
LOC100725073PID domain-containing protein. (745 aa)
ZFAND6Zinc finger AN1-type containing 6. (207 aa)
RAB38RAB38, member RAS oncogene family. (211 aa)
Rabgef1Uncharacterized protein. (491 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
ENSCPOP00000033061AP complex subunit beta. (889 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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