STRINGSTRING
LOC100727454 LOC100727454 HSD17B3 HSD17B3 Hsd3b1 Hsd3b1 LOC100727788 LOC100727788 LOC100724620 LOC100724620 HSD11B1 HSD11B1 AKR1D1 AKR1D1 H0V8N6_CAVPO H0V8N6_CAVPO LOC100725801 LOC100725801 HSD11B2 HSD11B2 SRD5A3 SRD5A3 CYP11B1 CYP11B1 CYP19A1 CYP19A1 CYP17A1 CYP17A1 Cyp11b2 Cyp11b2 SRD5A2 SRD5A2 LOC100734845 LOC100734845 SRD5A1 SRD5A1 HSD17B2 HSD17B2 HSD3B7 HSD3B7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC100727454Aldo_ket_red domain-containing protein. (304 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (300 aa)
Hsd3b13beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase; Belongs to the 3-beta-HSD family. (373 aa)
LOC100727788Uncharacterized protein; Belongs to the cytochrome P450 family. (212 aa)
LOC100724620Aldo-keto reductase family 1 member C3. (323 aa)
HSD11B1Corticosteroid 11-beta-dehydrogenase isozyme 1; Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta- hydroxycholesterol (By similarity). (300 aa)
AKR1D1Aldo-keto reductase family 1 member D1. (326 aa)
H0V8N6_CAVPOUncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (191 aa)
LOC1007258013Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (395 aa)
SRD5A3Steroid 5 alpha-reductase 3. (318 aa)
CYP11B1Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (409 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] (499 aa)
Cyp11b2Uncharacterized protein; Belongs to the cytochrome P450 family. (479 aa)
SRD5A2Steroid 5 alpha-reductase 2. (207 aa)
LOC100734845Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (381 aa)
HSD3B7Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; Belongs to the 3-beta-HSD family. (369 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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