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Bckdha Bckdha IDH3A IDH3A SUCLG1 SUCLG1 PDHX PDHX Sdhd Sdhd OGDH OGDH ACO1 ACO1 Dld Dld PDHB PDHB DBT DBT TXNRD3 TXNRD3 DHTKD1 DHTKD1 IDH2 IDH2 GOT1 GOT1 Pdha1 Pdha1 Dlst Dlst MDH2 MDH2 MDH1 MDH1 SUCLG2 SUCLG2 IDH1 IDH1 CS CS SUCLA2 SUCLA2 IDH3B IDH3B SDHB SDHB GOT1L1 GOT1L1 OGDHL OGDHL H0WAF5_CAVPO H0WAF5_CAVPO LOC100725076 LOC100725076 SDHC SDHC IDH3G IDH3G ACO2 ACO2 FH FH BCKDHB BCKDHB ENSCPOP00000026353 ENSCPOP00000026353 DLAT DLAT GOT2 GOT2 ENSCPOP00000032995 ENSCPOP00000032995
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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Bckdha2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (446 aa)
IDH3AIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (379 aa)
SUCLG1Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. (346 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (442 aa)
SdhdSuccinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
OGDHOxoglutarate dehydrogenase. (1038 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
DldDihydrolipoyl dehydrogenase. (509 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
DBTDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (482 aa)
TXNRD3Thioredoxin reductase 3. (612 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (920 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
GOT1Aspartate aminotransferase. (413 aa)
Pdha1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
DlstLipoyl-binding domain-containing protein. (440 aa)
MDH2Malate dehydrogenase. (338 aa)
MDH1Malate dehydrogenase. (335 aa)
SUCLG2Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (404 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
CSCitrate synthase; Belongs to the citrate synthase family. (466 aa)
SUCLA2Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (457 aa)
IDH3BIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (383 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (387 aa)
OGDHLOxoglutarate dehydrogenase like. (1022 aa)
H0WAF5_CAVPOIso_dh domain-containing protein. (332 aa)
LOC100725076Iso_dh domain-containing protein. (377 aa)
SDHCSuccinate dehydrogenase complex subunit C. (169 aa)
IDH3GIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (393 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (780 aa)
FHFumarate hydratase. (508 aa)
BCKDHBBranched chain keto acid dehydrogenase E1 subunit beta. (392 aa)
ENSCPOP00000026353Dihydrolipoyl dehydrogenase. (501 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (650 aa)
GOT2Aspartate aminotransferase. (430 aa)
ENSCPOP00000032995Lipoyl-binding domain-containing protein. (440 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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