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NARF NARF GLRX5 GLRX5 BLVRB BLVRB Glrx3 Glrx3 HMOX2 HMOX2 FXN FXN LIAS LIAS ABCB6 ABCB6 UROS UROS ENDOV ENDOV HMBS HMBS ABCE1 ABCE1 ALAD ALAD CIAO2B CIAO2B NUBP2 NUBP2 BLVRA BLVRA NDOR1 NDOR1 CIAO3 CIAO3 NUBPL NUBPL BOLA1 BOLA1 ABCB7 ABCB7 ISCU ISCU MOCOS MOCOS LIPT1 LIPT1 FECH FECH HSCB HSCB Nfs1 Nfs1 H0W0H8_CAVPO H0W0H8_CAVPO NUBP1 NUBP1 SCLY SCLY SLC2A10 SLC2A10 LIPT2 LIPT2 HMOX1 HMOX1 UROD UROD NFU1 NFU1 CIAO2A CIAO2A LTO1 LTO1 CPOX CPOX Lyrm4 Lyrm4 ENSCPOP00000025134 ENSCPOP00000025134 Isca1 Isca1 GFOD1 GFOD1 Bola2b Bola2b IBA57 IBA57 CIAO1 CIAO1 ENSCPOP00000027472 ENSCPOP00000027472 MMS19 MMS19 SLC25A38 SLC25A38 ENSCPOP00000028454 ENSCPOP00000028454 YAE1 YAE1 GFOD2 GFOD2 PPOX PPOX ISCA2 ISCA2 CIAPIN1 CIAPIN1 BOLA3 BOLA3 ART3 ART3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (455 aa)
GLRX5Glutaredoxin 5. (156 aa)
BLVRBBiliverdin reductase B. (206 aa)
Glrx3Uncharacterized protein. (171 aa)
HMOX2Heme oxygenase 2. (316 aa)
FXNFrataxin. (211 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (371 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (843 aa)
UROSUroporphyrinogen III synthase. (265 aa)
ENDOVEndonuclease V. (260 aa)
HMBSHydroxymethylbilane synthase. (361 aa)
ABCE1ATP binding cassette subfamily E member 1. (599 aa)
ALADDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (330 aa)
CIAO2BCytosolic iron-sulfur assembly component 2B. (165 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
BLVRABiliverdin reductase A; Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor; Belongs to the Gfo/Idh/MocA family. Biliverdin reductase subfamily. (296 aa)
NDOR1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (598 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (476 aa)
NUBPLNucleotide binding protein like. (317 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (134 aa)
ABCB7ATP binding cassette subfamily B member 7. (752 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (166 aa)
MOCOSMolybdenum cofactor sulfurase; Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. (873 aa)
LIPT1Lipoyltransferase 1. (230 aa)
FECHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (424 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (235 aa)
Nfs1Aminotran_5 domain-containing protein. (436 aa)
H0W0H8_CAVPOUncharacterized protein. (336 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (323 aa)
SCLYSelenocysteine lyase. (433 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (539 aa)
LIPT2Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (230 aa)
HMOX1Heme oxygenase 1. (297 aa)
URODUroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (367 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (253 aa)
CIAO2ACytosolic iron-sulfur assembly component 2A. (160 aa)
LTO1LTO1 maturation factor of ABCE1. (137 aa)
CPOXCoproporphyrinogen oxidase. (436 aa)
Lyrm4Uncharacterized protein; Belongs to the complex I LYR family. (91 aa)
ENSCPOP00000025134Uncharacterized protein. (107 aa)
Isca1Fe-S_biosyn domain-containing protein. (129 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (390 aa)
Bola2bUncharacterized protein; Belongs to the BolA/IbaG family. (86 aa)
IBA57Iron-sulfur cluster assembly factor IBA57. (357 aa)
CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (336 aa)
ENSCPOP00000027472Fe-S_biosyn domain-containing protein. (113 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1027 aa)
SLC25A38Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. (299 aa)
ENSCPOP00000028454Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (259 aa)
YAE1YAE1 maturation factor of ABCE1. (226 aa)
GFOD2Glucose-fructose oxidoreductase domain containing 2. (385 aa)
PPOXProtoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (477 aa)
ISCA2Iron-sulfur cluster assembly 2. (154 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (315 aa)
BOLA3BolA family member 3; Belongs to the BolA/IbaG family. (110 aa)
ART3NAD(P)(+)--arginine ADP-ribosyltransferase. (370 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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