STRINGSTRING
SESN2 SESN2 Tacc2 Tacc2 SIRT1 SIRT1 ZNF322 ZNF322 DMRTC2 DMRTC2 MLST8 MLST8 PPM1A PPM1A NPRL2 NPRL2 PRKAG1 PRKAG1 KMT2D KMT2D RHEBL1 RHEBL1 MYBPHL MYBPHL TSC2 TSC2 PDPK1 PDPK1 CAB39L CAB39L RRAGD RRAGD TSC1 TSC1 CD68 CD68 Crygn Crygn PRKAA1 PRKAA1 DMRT3 DMRT3 Depdc5 Depdc5 CUNH16orf89 CUNH16orf89 SZT2 SZT2 SLC38A8 SLC38A8 TSSK3 TSSK3 LIPN LIPN SGK3 SGK3 RRAGC RRAGC STK32A STK32A SLC36A2 SLC36A2 DMRT2 DMRT2 Ctsd Ctsd H0VCZ7_CAVPO H0VCZ7_CAVPO SLC38A7 SLC38A7 SLC38A10 SLC38A10 FNIP2 FNIP2 SLC36A3 SLC36A3 PRKAA2 PRKAA2 KPTN KPTN RRAGB RRAGB METTL25 METTL25 MTOR MTOR SLC38A9 SLC38A9 MIOS MIOS Cetn2 Cetn2 FLCN FLCN CRYBB3 CRYBB3 STRADB STRADB Lamtor4 Lamtor4 DEPTOR DEPTOR SESN1 SESN1 BMT2 BMT2 SLC36A1 SLC36A1 CASTOR1 CASTOR1 RRNAD1 RRNAD1 RPS6KB1 RPS6KB1 Lamp3 Lamp3 WDR24 WDR24 ATAT1 ATAT1 AKT3 AKT3 Prkab1 Prkab1 PRKAG2 PRKAG2 SEC13 SEC13 FOXO6 FOXO6 RRAGA RRAGA LAMP1 LAMP1 ZNF189 ZNF189 SESN3 SESN3 Tssk2 Tssk2 ZNF668 ZNF668 PRKAG3 PRKAG3 H0W426_CAVPO H0W426_CAVPO H0W444_CAVPO H0W444_CAVPO Foxo3 Foxo3 IMMP1L IMMP1L STAC2 STAC2 AKT1S1 AKT1S1 Dmrtb1 Dmrtb1 ZBTB45 ZBTB45 TSSK6 TSSK6 PSMG1 PSMG1 ZNF385A ZNF385A LAMTOR5 LAMTOR5 STRADA STRADA Kiaa1671 Kiaa1671 ITFG2 ITFG2 ENSCPOP00000023010 ENSCPOP00000023010 BNIP3L BNIP3L ZNF385B ZNF385B LAMTOR1 LAMTOR1 RPS6KB2 RPS6KB2 LAMTOR2 LAMTOR2 LOC100731816 LOC100731816 ZNF8 ZNF8 C12orf66 C12orf66 RREB1 RREB1 TRIB1 TRIB1 ENSCPOP00000024869 ENSCPOP00000024869 LOC100723178 LOC100723178 NPRL3 NPRL3 LRRD1 LRRD1 ENSCPOP00000025109 ENSCPOP00000025109 RICTOR RICTOR ZNF81 ZNF81 STK11 STK11 AKT1 AKT1 ENSCPOP00000026200 ENSCPOP00000026200 FOXO4 FOXO4 STK40 STK40 ZNF891 ZNF891 PRR5 PRR5 ZBTB38 ZBTB38 LAMTOR3 LAMTOR3 MAPKAP1 MAPKAP1 SLC36A4 SLC36A4 Ppm1b Ppm1b Castor2 Castor2 ENSCPOP00000028708 ENSCPOP00000028708 WDR59 WDR59 SEH1L SEH1L PPM1N PPM1N LOC100725530 LOC100725530 ENSCPOP00000029186 ENSCPOP00000029186 ENSCPOP00000029281 ENSCPOP00000029281 PRKAB2 PRKAB2 ENSCPOP00000029383 ENSCPOP00000029383 CAMKK1 CAMKK1 BNIP3 BNIP3 LAMP2 LAMP2 ENSCPOP00000030085 ENSCPOP00000030085 TBC1D7 TBC1D7 RHEB RHEB TRIB2 TRIB2 SGK2 SGK2 AKT2 AKT2 RPTOR RPTOR CAB39 CAB39 STEAP3 STEAP3 ZNF576 ZNF576 ENSCPOP00000032352 ENSCPOP00000032352 FNIP1 FNIP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN2Sestrin 2. (480 aa)
Tacc2TACC_C domain-containing protein. (1125 aa)
SIRT1Sirtuin 1. (717 aa)
ZNF322Zinc finger protein 322. (398 aa)
DMRTC2DMRT like family C2. (373 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
PRKAG1Protein kinase AMP-activated non-catalytic subunit gamma 1. (329 aa)
KMT2DLysine methyltransferase 2D. (5430 aa)
RHEBL1RHEB like 1. (183 aa)
MYBPHLMyosin binding protein H like. (354 aa)
TSC2TSC complex subunit 2. (1745 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (550 aa)
CAB39LCalcium binding protein 39 like. (334 aa)
RRAGDRas related GTP binding D. (348 aa)
TSC1TSC complex subunit 1. (1166 aa)
CD68CD68 molecule. (335 aa)
CrygnGammaN-crystallin; Belongs to the beta/gamma-crystallin family. (183 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (471 aa)
Depdc5DEP domain-containing protein. (1576 aa)
CUNH16orf89Uncharacterized protein. (345 aa)
SZT2SZT2 subunit of KICSTOR complex. (3427 aa)
SLC38A8Solute carrier family 38 member 8. (431 aa)
TSSK3Testis specific serine kinase 3. (268 aa)
LIPNLipase; Belongs to the AB hydrolase superfamily. Lipase family. (400 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (498 aa)
RRAGCRas related GTP binding C. (399 aa)
STK32ASerine/threonine kinase 32A; Belongs to the protein kinase superfamily. (396 aa)
SLC36A2Solute carrier family 36 member 2. (483 aa)
DMRT2Doublesex and mab-3 related transcription factor 2. (559 aa)
CtsdPeptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (407 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
SLC38A7Solute carrier family 38 member 7. (463 aa)
SLC38A10Solute carrier family 38 member 10. (1104 aa)
FNIP2Folliculin interacting protein 2. (1079 aa)
SLC36A3Solute carrier family 36 member 3. (426 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
KPTNKaptin, actin binding protein. (435 aa)
RRAGBRas related GTP binding B. (362 aa)
METTL25Methyltransferase like 25. (587 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
SLC38A9Solute carrier family 38 member 9. (559 aa)
MIOSMeiosis regulator for oocyte development. (875 aa)
Cetn2Uncharacterized protein. (172 aa)
FLCNFolliculin. (579 aa)
CRYBB3BetaB3-crystallin; Belongs to the beta/gamma-crystallin family. (211 aa)
STRADBSTE20 related adaptor beta. (416 aa)
Lamtor4Uncharacterized protein. (99 aa)
DEPTORDEP domain containing MTOR interacting protein. (403 aa)
SESN1Sestrin 1. (564 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (381 aa)
SLC36A1Solute carrier family 36 member 1. (442 aa)
CASTOR1Cytosolic arginine sensor for mTORC1 subunit 1. (329 aa)
RRNAD1Ribosomal RNA adenine dimethylase domain containing 1. (474 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (503 aa)
Lamp3Uncharacterized protein. (418 aa)
WDR24WD repeat domain 24. (790 aa)
ATAT1Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (425 aa)
AKT3AKT serine/threonine kinase 3. (470 aa)
Prkab1AMPKBI domain-containing protein. (270 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (567 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (322 aa)
FOXO6Forkhead box O6. (512 aa)
RRAGARas related GTP binding A. (313 aa)
LAMP1Lysosomal associated membrane protein 1. (410 aa)
ZNF189Zinc finger protein 189. (611 aa)
SESN3Sestrin 3. (414 aa)
Tssk2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (355 aa)
ZNF668Zinc finger protein 668. (611 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (465 aa)
H0W426_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (416 aa)
H0W444_CAVPOUncharacterized protein. (91 aa)
Foxo3Forkhead box O3. (660 aa)
IMMP1LInner mitochondrial membrane peptidase subunit 1. (132 aa)
STAC2SH3 and cysteine rich domain 2. (402 aa)
AKT1S1AKT1 substrate 1. (282 aa)
Dmrtb1DM domain-containing protein. (313 aa)
ZBTB45Zinc finger and BTB domain containing 45. (480 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PSMG1Proteasome assembly chaperone 1; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with psmg2. (289 aa)
ZNF385AZinc finger protein 385A. (386 aa)
LAMTOR5Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5. (91 aa)
STRADASTE20 related adaptor alpha. (431 aa)
Kiaa1671Tankyrase_bdg_C domain-containing protein. (386 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (444 aa)
ENSCPOP00000023010Uncharacterized protein. (567 aa)
BNIP3LBCL2 interacting protein 3 like. (214 aa)
ZNF385BZinc finger protein 385B. (477 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (484 aa)
LAMTOR2Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2. (125 aa)
LOC100731816Uncharacterized protein. (647 aa)
ZNF8Zinc finger protein 8. (484 aa)
C12orf66Chromosome 12 open reading frame 66. (445 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
TRIB1Tribbles pseudokinase 1. (323 aa)
ENSCPOP00000024869Uncharacterized protein. (325 aa)
LOC100723178Uncharacterized protein. (725 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
LRRD1Leucine rich repeats and death domain containing 1. (856 aa)
ENSCPOP00000025109Uncharacterized protein. (817 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1471 aa)
ZNF81Zinc finger protein 81. (645 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSCPOP00000026200Uncharacterized protein. (708 aa)
FOXO4Forkhead box O4. (505 aa)
STK40Serine/threonine kinase 40. (438 aa)
ZNF891Zinc finger protein 891. (532 aa)
PRR5Proline rich 5. (358 aa)
ZBTB38Zinc finger and BTB domain containing 38. (1194 aa)
LAMTOR3Late endosomal/lysosomal adaptor, MAPK and MTOR activator 3. (121 aa)
MAPKAP1MAPK associated protein 1. (522 aa)
SLC36A4Solute carrier family 36 member 4. (484 aa)
Ppm1bPPM-type phosphatase domain-containing protein. (479 aa)
Castor2Uncharacterized protein. (356 aa)
ENSCPOP00000028708Uncharacterized protein. (153 aa)
WDR59WD repeat domain 59. (983 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (418 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (393 aa)
LOC100725530Uncharacterized protein. (652 aa)
ENSCPOP00000029186Uncharacterized protein. (707 aa)
ENSCPOP00000029281Uncharacterized protein. (504 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
ENSCPOP00000029383Uncharacterized protein. (563 aa)
CAMKK1Calcium/calmodulin dependent protein kinase kinase 1. (505 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
LAMP2Lysosomal associated membrane protein 2. (408 aa)
ENSCPOP00000030085AMPKBI domain-containing protein. (256 aa)
TBC1D7TBC1 domain family member 7. (293 aa)
RHEBUncharacterized protein. (184 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
CAB39Calcium binding protein 39. (341 aa)
STEAP3STEAP3 metalloreductase. (522 aa)
ZNF576Zinc finger protein 576. (170 aa)
ENSCPOP00000032352Uncharacterized protein. (599 aa)
FNIP1Folliculin interacting protein 1. (1164 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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