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GUCY1A2 GUCY1A2 NPR2 NPR2 Pde11a Pde11a LOC100735737 LOC100735737 Pde8b Pde8b PRKAR2A PRKAR2A GUCY2D GUCY2D PDE6A PDE6A PRKAR2B PRKAR2B ADCY1 ADCY1 GNAL GNAL THAP7 THAP7 PRKCB PRKCB PRKAR1A PRKAR1A PDE6C PDE6C LOC100720455 LOC100720455 RHO RHO PDZK1 PDZK1 PTRHD1 PTRHD1 ADCY3 ADCY3 AKAP11 AKAP11 GUCY2F GUCY2F CAMK2A CAMK2A GUCA2B GUCA2B ADCY8 ADCY8 GNAT1 GNAT1 GNGT1 GNGT1 GUCY2C GUCY2C PDE5A PDE5A MPP1 MPP1 AKAP8 AKAP8 GUCA1B GUCA1B RAPGEF4 RAPGEF4 ADCY2 ADCY2 GUCY1A1 GUCY1A1 PDE3A PDE3A Gnat2 Gnat2 CNGA2 CNGA2 ITPR2 ITPR2 CNGB3 CNGB3 PRKAR1B PRKAR1B AKAP1 AKAP1 ADCY5 ADCY5 H0VQQ2_CAVPO H0VQQ2_CAVPO ADCY4 ADCY4 PDE3B PDE3B GUCY1B1 GUCY1B1 PRKG2 PRKG2 Guca1a Guca1a PDZD3 PDZD3 PDE4A PDE4A GUCA2A GUCA2A NPPA NPPA CAMK2B CAMK2B CNGA1 CNGA1 PDE6B PDE6B NPR1 NPR1 CNGA3 CNGA3 NPPC NPPC CNGA4 CNGA4 PDE6G PDE6G CCDC88B CCDC88B ITPR3 ITPR3 LOC100721548 LOC100721548 PDE4D PDE4D LIPE LIPE ENSCPOP00000022086 ENSCPOP00000022086 ENSCPOP00000022441 ENSCPOP00000022441 CAMK2G CAMK2G ENSCPOP00000023932 ENSCPOP00000023932 CNBD2 CNBD2 PKIG PKIG PDE6H PDE6H PRKCG PRKCG PRKG1 PRKG1 ADCY9 ADCY9 ENSCPOP00000026472 ENSCPOP00000026472 PRKACB PRKACB PDE4B PDE4B PDE2A PDE2A PDE9A PDE9A ADCY6 ADCY6 ADCY7 ADCY7 LOC100723267 LOC100723267 NCALD NCALD PKIA PKIA PDE8A PDE8A Ank3 Ank3 ITPR1 ITPR1 Camk2d Camk2d AKAP10 AKAP10 ENSCPOP00000031664 ENSCPOP00000031664 LOC100721887 LOC100721887 Prkaca Prkaca MRVI1 MRVI1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (635 aa)
NPR2Guanylate cyclase. (1047 aa)
Pde11aPhosphodiesterase. (888 aa)
LOC100735737Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (209 aa)
Pde8bPhosphodiesterase. (785 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (395 aa)
GUCY2DGuanylate cyclase. (1102 aa)
PDE6APhosphodiesterase. (860 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
ADCY1Adenylate cyclase 1. (944 aa)
GNALG protein subunit alpha L. (372 aa)
THAP7THAP domain containing 7. (309 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (643 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
PDE6CPhosphodiesterase. (862 aa)
LOC100720455Olfactory receptor. (304 aa)
RHORhodopsin. (348 aa)
PDZK1PDZ domain containing 1. (513 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
AKAP11A-kinase anchoring protein 11. (1891 aa)
GUCY2FGuanylate cyclase. (1109 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
GUCA2BGuanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport; Belongs to the guanylin family. (113 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
GNAT1Alpha-transducin. (350 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GUCY2CHeat-stable enterotoxin receptor; Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1079 aa)
PDE5APhosphodiesterase. (863 aa)
MPP1Membrane palmitoylated protein 1; Belongs to the MAGUK family. (466 aa)
AKAP8A-kinase anchoring protein 8; Belongs to the AKAP95 family. (670 aa)
GUCA1BGuanylate cyclase activator 1B. (200 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (989 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1095 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PDE3APhosphodiesterase. (1132 aa)
Gnat2Uncharacterized protein. (354 aa)
CNGA2Cyclic nucleotide gated channel subunit alpha 2. (663 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2. (2622 aa)
CNGB3Cyclic nucleotide gated channel subunit beta 3. (667 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (381 aa)
AKAP1A-kinase anchoring protein 1. (860 aa)
ADCY5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1032 aa)
H0VQQ2_CAVPOCyclic nucleotide-binding domain-containing protein. (852 aa)
ADCY4Adenylate cyclase type 4; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
PDE3BPhosphodiesterase. (931 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (622 aa)
PRKG2cGMP-dependent protein kinase. (758 aa)
Guca1aUncharacterized protein. (200 aa)
PDZD3PDZ domain containing 3. (495 aa)
PDE4AcAMP-specific 3',5'-cyclic phosphodiesterase 4A; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. (863 aa)
GUCA2AGuanylin; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins; Belongs to the guanylin family. (119 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
CAMK2BCalcium/calmodulin dependent protein kinase II beta. (659 aa)
CNGA1Cyclic nucleotide gated channel subunit alpha 1. (507 aa)
PDE6BPhosphodiesterase. (854 aa)
NPR1Guanylate cyclase. (881 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (647 aa)
NPPCNatriuretic peptide C. (126 aa)
CNGA4Cyclic nucleotide gated channel subunit alpha 4. (574 aa)
PDE6GRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma; Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones (By similarity). (87 aa)
CCDC88BCoiled-coil domain containing 88B. (1503 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2663 aa)
LOC100721548Olfactory receptor. (314 aa)
PDE4DPhosphodiesterase. (782 aa)
LIPELipase E, hormone sensitive type. (802 aa)
ENSCPOP00000022086PDEase domain-containing protein; Belongs to the cyclic nucleotide phosphodiesterase family. (593 aa)
ENSCPOP00000022441ANF_receptor domain-containing protein. (298 aa)
CAMK2GCalcium/calmodulin dependent protein kinase II gamma. (545 aa)
ENSCPOP00000023932Uncharacterized protein. (332 aa)
CNBD2Cyclic nucleotide binding domain containing 2. (587 aa)
PKIGcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
PDE6HPhosphodiesterase 6H. (83 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1353 aa)
ENSCPOP00000026472Uncharacterized protein. (286 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
PDE4BPhosphodiesterase. (736 aa)
PDE2APhosphodiesterase. (950 aa)
PDE9APhosphodiesterase. (534 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1168 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1075 aa)
LOC100723267Olfactory receptor. (312 aa)
NCALDNeurocalcin delta. (193 aa)
PKIAcAMP-dependent protein kinase inhibitor; Belongs to the PKI family. (76 aa)
PDE8APhosphodiesterase. (826 aa)
Ank3Uncharacterized protein. (1948 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2738 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
AKAP10A-kinase anchoring protein 10. (644 aa)
ENSCPOP00000031664Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (702 aa)
LOC100721887G_PROTEIN_RECEP_F1_2 domain-containing protein. (312 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
MRVI1Murine retrovirus integration site 1 homolog. (858 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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