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METTL16 METTL16 DIMT1 DIMT1 Tfb2m Tfb2m RRNAD1 RRNAD1 RPUSD4 RPUSD4 EMG1 EMG1 MRM3 MRM3 NSUN5 NSUN5 Mrm2 Mrm2 FBLL1 FBLL1 Nop2 Nop2 BUD23 BUD23 TSR3 TSR3 TRMT61B TRMT61B FTSJ3 FTSJ3 ZCCHC4 ZCCHC4 RPUSD2 RPUSD2 NAT10 NAT10 RPUSD1 RPUSD1 TFB1M TFB1M DKC1 DKC1 METTL5 METTL5 FDXACB1 FDXACB1 MRM1 MRM1 TRMT112 TRMT112 NSUN3 NSUN3 NSUN4 NSUN4 METTL15 METTL15 GAR1 GAR1 RPUSD3 RPUSD3 FBL FBL NOP10 NOP10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (552 aa)
DIMT1rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (313 aa)
Tfb2mrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (392 aa)
RRNAD1Ribosomal RNA adenine dimethylase domain containing 1. (474 aa)
RPUSD4RNA pseudouridine synthase D4. (375 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
MRM3Mitochondrial rRNA methyltransferase 3. (425 aa)
NSUN5NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (461 aa)
Mrm2Mitochondrial rRNA methyltransferase 2. (250 aa)
FBLL1Fibrillarin like 1. (307 aa)
Nop2SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (787 aa)
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor. (281 aa)
TSR3Probable ribosome biogenesis protein C16orf42 homolog; Probable pre-rRNA processing protein involved in ribosome biogenesis. (300 aa)
TRMT61BtRNA methyltransferase 61B. (480 aa)
FTSJ3pre-rRNA processing protein FTSJ3; Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (838 aa)
ZCCHC4Zinc finger CCHC-type containing 4. (518 aa)
RPUSD2RNA pseudouridine synthase domain containing 2. (545 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1030 aa)
RPUSD1RNA pseudouridine synthase domain containing 1. (306 aa)
TFB1MrRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (346 aa)
DKC1Dyskerin pseudouridine synthase 1. (513 aa)
METTL5Methyltransferase like 5. (209 aa)
FDXACB1Ferredoxin-fold anticodon binding domain containing 1. (622 aa)
MRM1Mitochondrial rRNA methyltransferase 1. (350 aa)
TRMT112tRNA methyltransferase subunit 11-2. (132 aa)
NSUN3NOP2/Sun RNA methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (334 aa)
NSUN4NOP2/Sun RNA methyltransferase 4; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (381 aa)
METTL15Methyltransferase like 15. (490 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (222 aa)
RPUSD3RNA pseudouridine synthase D3. (355 aa)
FBLFibrillarin. (320 aa)
NOP10NOP10 ribonucleoprotein. (64 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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