37 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PABPN1L	Poly(A) binding protein nuclear 1 like, cytoplasmic. (273 aa)
	PARN	Poly(A)-specific ribonuclease. (637 aa)
	PATL2	PAT1 homolog 2. (517 aa)
	POLR2D	RNA polymerase II subunit D. (142 aa)
	DCP2	Decapping mRNA 2. (422 aa)
	PDE12	Phosphodiesterase 12. (608 aa)
	DCP1A	Decapping mRNA 1A. (601 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	CNOT3	CCR4-NOT transcription complex subunit 3. (751 aa)
	EXOSC9	Exosome component 9. (439 aa)
	ZFP36	ZFP36 ring finger protein. (313 aa)
	CNOT6	CCR4-NOT transcription complex subunit 6. (534 aa)
	EXOSC5	Exosome component 5. (240 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	EXOSC2	Exosome component 2. (293 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (751 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1188 aa)
	LRRC27	Leucine rich repeat containing 27. (508 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (403 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (518 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1204 aa)
	SAMD4A	Sterile alpha motif domain containing 4A. (714 aa)
	DCPS	Decapping enzyme, scavenger. (337 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2294 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (462 aa)
	EXOSC3	Exosome component 3. (275 aa)
	PATL1	PAT1 homolog 1, processing body mRNA decay factor. (790 aa)
	SAMD4B	Sterile alpha motif domain containing 4B. (692 aa)
	DCP1B	Decapping mRNA 1B. (592 aa)
	EXOSC7	Exosome component 7. (291 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (544 aa)
	EXOSC8	Exosome component 8. (276 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1116 aa)
	MLH1	MutL homolog 1. (758 aa)
	NOCT	Nocturnin. (432 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNOT1	CNOT2	ENSCPOP00000011726	ENSCPOP00000004286	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.999
CNOT1	CNOT3	ENSCPOP00000011726	ENSCPOP00000024185	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 3.	0.999
CNOT1	CNOT6	ENSCPOP00000011726	ENSCPOP00000025960	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6.	0.987
CNOT1	CNOT6L	ENSCPOP00000011726	ENSCPOP00000009284	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6 like.	0.996
CNOT1	CNOT7	ENSCPOP00000011726	ENSCPOP00000023165	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 7.	0.999
CNOT1	CNOT8	ENSCPOP00000011726	ENSCPOP00000003131	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 8.	0.990
CNOT1	DCP1A	ENSCPOP00000011726	ENSCPOP00000000063	CCR4-NOT transcription complex subunit 1.	Decapping mRNA 1A.	0.528
CNOT1	DCP1B	ENSCPOP00000011726	ENSCPOP00000004748	CCR4-NOT transcription complex subunit 1.	Decapping mRNA 1B.	0.493
CNOT1	DCP2	ENSCPOP00000011726	ENSCPOP00000001487	CCR4-NOT transcription complex subunit 1.	Decapping mRNA 2.	0.573
CNOT1	LRRC27	ENSCPOP00000011726	ENSCPOP00000002999	CCR4-NOT transcription complex subunit 1.	Leucine rich repeat containing 27.	0.963
CNOT1	LSM1	ENSCPOP00000011726	ENSCPOP00000030321	CCR4-NOT transcription complex subunit 1.	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.	0.573
CNOT1	NOCT	ENSCPOP00000011726	ENSCPOP00000003453	CCR4-NOT transcription complex subunit 1.	Nocturnin.	0.940
CNOT1	PABPN1L	ENSCPOP00000011726	ENSCPOP00000018565	CCR4-NOT transcription complex subunit 1.	Poly(A) binding protein nuclear 1 like, cytoplasmic.	0.402
CNOT1	PAN2	ENSCPOP00000011726	ENSCPOP00000013443	CCR4-NOT transcription complex subunit 1.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...]	0.558
CNOT1	PAN3	ENSCPOP00000011726	ENSCPOP00000030837	CCR4-NOT transcription complex subunit 1.	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...]	0.456
CNOT1	PARN	ENSCPOP00000011726	ENSCPOP00000022282	CCR4-NOT transcription complex subunit 1.	Poly(A)-specific ribonuclease.	0.441
CNOT1	PATL1	ENSCPOP00000011726	ENSCPOP00000006154	CCR4-NOT transcription complex subunit 1.	PAT1 homolog 1, processing body mRNA decay factor.	0.994
CNOT1	PATL2	ENSCPOP00000011726	ENSCPOP00000002654	CCR4-NOT transcription complex subunit 1.	PAT1 homolog 2.	0.911
CNOT1	PDE12	ENSCPOP00000011726	ENSCPOP00000001461	CCR4-NOT transcription complex subunit 1.	Phosphodiesterase 12.	0.940
CNOT1	RC3H1	ENSCPOP00000011726	ENSCPOP00000003922	CCR4-NOT transcription complex subunit 1.	Ring finger and CCCH-type domains 1.	0.800