STRINGSTRING
HOXB5 HOXB5 POLR2F POLR2F RERG RERG CHCHD1 CHCHD1 ENSCPOP00000031793 ENSCPOP00000031793 JAZF1 JAZF1 LOC100725073 LOC100725073 SMUG1 SMUG1 ENSCPOP00000032877 ENSCPOP00000032877 SAP30L SAP30L ENSCPOP00000027005 ENSCPOP00000027005 GAR1 GAR1 STAG2 STAG2 ENSCPOP00000027535 ENSCPOP00000027535 NEDD1 NEDD1 MAP3K14 MAP3K14 CC2D1A CC2D1A ZNF174 ZNF174 POLR1C POLR1C SMARCB1 SMARCB1 ARHGAP32 ARHGAP32 STN1 STN1 NRIP1 NRIP1 SMAD7 SMAD7 RREB1 RREB1 Fblim1 Fblim1 FBL FBL Eif3l Eif3l NUAK1 NUAK1 SPATA2 SPATA2 ENSCPOP00000023362 ENSCPOP00000023362 UTP15 UTP15 Pafah1b2 Pafah1b2 NOP58 NOP58 SELENBP1 SELENBP1 AKNA AKNA EN2 EN2 NFKBIE NFKBIE FBLL1 FBLL1 TRAF4 TRAF4 PAK6 PAK6 SNAI1 SNAI1 LOC100721657 LOC100721657 RPP38 RPP38 RGS22 RGS22 POLR1B POLR1B NOP53 NOP53 STOX1 STOX1 SMARCA4 SMARCA4 ESRRA ESRRA PRMT7 PRMT7 NOP56 NOP56 FHIT FHIT CDK7 CDK7 SAMD4A SAMD4A DCLRE1A DCLRE1A SESN1 SESN1 MRI1 MRI1 LOC106026468 LOC106026468 MBD6 MBD6 MALT1 MALT1 TRIM27 TRIM27 USO1 USO1 TXNRD1 TXNRD1 KIT KIT Ccr2 Ccr2 WDR43 WDR43 CD2AP CD2AP TAF1C TAF1C Kdm4a Kdm4a POLR1E POLR1E OTP OTP LEO1 LEO1 TERF1 TERF1 RAI14 RAI14 TOP1 TOP1 Dab2 Dab2 RSAD2 RSAD2 HERC4 HERC4 IP6K2 IP6K2 PTPN13 PTPN13 CAMK4 CAMK4 URB1 URB1 DCAF1 DCAF1 DEAF1 DEAF1 UTP4 UTP4 NUFIP1 NUFIP1 NOLC1 NOLC1 EXOSC8 EXOSC8 NFIB NFIB ORC6 ORC6 RPAIN RPAIN TCOF1 TCOF1 AFF4 AFF4 TAF4B TAF4B MLLT1 MLLT1 NCL NCL LIPA LIPA ICK ICK AGER AGER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HOXB5Homeobox B5. (270 aa)
POLR2FRNA polymerase II subunit F. (127 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
CHCHD1Coiled-coil-helix-coiled-coil-helix domain containing 1. (118 aa)
ENSCPOP00000031793Uncharacterized protein. (352 aa)
JAZF1JAZF zinc finger 1. (204 aa)
LOC100725073PID domain-containing protein. (745 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)
ENSCPOP00000032877PCI domain-containing protein. (324 aa)
SAP30LSAP30 like. (126 aa)
ENSCPOP00000027005UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (222 aa)
STAG2Stromal antigen 2. (1149 aa)
ENSCPOP00000027535Uncharacterized protein. (148 aa)
NEDD1NEDD1 gamma-tubulin ring complex targeting factor. (691 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (937 aa)
CC2D1ACoiled-coil and C2 domain containing 1A. (947 aa)
ZNF174Zinc finger protein 174. (408 aa)
POLR1CRNA polymerase I and III subunit C. (346 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (376 aa)
ARHGAP32Rho GTPase activating protein 32. (2067 aa)
STN1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (375 aa)
NRIP1Nuclear receptor interacting protein 1. (1157 aa)
SMAD7SMAD family member 7. (221 aa)
RREB1Ras responsive element binding protein 1. (1738 aa)
Fblim1Uncharacterized protein. (532 aa)
FBLFibrillarin. (320 aa)
Eif3lEukaryotic translation initiation factor 3 subunit L; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (607 aa)
NUAK1NUAK family kinase 1. (572 aa)
SPATA2Spermatogenesis associated 2. (513 aa)
ENSCPOP00000023362UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
UTP15UTP15 small subunit processome component. (517 aa)
Pafah1b2SGNH_hydro domain-containing protein. (202 aa)
NOP58NOP58 ribonucleoprotein. (512 aa)
SELENBP1Selenium binding protein 1. (471 aa)
AKNAAT-hook transcription factor. (1310 aa)
EN2Homeobox protein engrailed-like. (323 aa)
NFKBIENFKB inhibitor epsilon. (341 aa)
FBLL1Fibrillarin like 1. (307 aa)
TRAF4TNF receptor-associated factor. (470 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LOC100721657Uncharacterized protein. (854 aa)
RPP38Ribonuclease P/MRP subunit p38. (284 aa)
RGS22Regulator of G protein signaling 22. (1187 aa)
POLR1BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1135 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (476 aa)
STOX1Storkhead box 1. (987 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1636 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
PRMT7Protein arginine N-methyltransferase; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being r [...] (679 aa)
NOP56NOP56 ribonucleoprotein. (592 aa)
FHITBis(5'-adenosyl)-triphosphatase. (150 aa)
CDK7Cyclin dependent kinase 7. (335 aa)
SAMD4ASterile alpha motif domain containing 4A. (714 aa)
DCLRE1ADNA cross-link repair 1A. (913 aa)
SESN1Sestrin 1. (564 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (362 aa)
LOC106026468UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa)
MBD6Methyl-CpG binding domain protein 6. (983 aa)
MALT1MALT1 paracaspase. (780 aa)
TRIM27Tripartite motif containing 27. (504 aa)
USO1USO1 vesicle transport factor. (901 aa)
TXNRD1Thioredoxin reductase 1. (499 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
Ccr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
WDR43WD repeat domain 43. (654 aa)
CD2APCD2 associated protein. (632 aa)
TAF1CTATA-box binding protein associated factor, RNA polymerase I subunit C. (837 aa)
Kdm4aUncharacterized protein. (978 aa)
POLR1ERNA polymerase I subunit E. (418 aa)
OTPOrthopedia homeobox. (325 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (658 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (409 aa)
RAI14Retinoic acid induced 14. (980 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa)
Dab2PID domain-containing protein. (766 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (358 aa)
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1030 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (449 aa)
PTPN13Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2480 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV. (418 aa)
URB1URB1 ribosome biogenesis homolog. (2253 aa)
DCAF1DDB1 and CUL4 associated factor 1. (1451 aa)
DEAF1DEAF1 transcription factor. (565 aa)
UTP4UTP4 small subunit processome component. (686 aa)
NUFIP1Nuclear FMR1 interacting protein 1. (491 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (732 aa)
EXOSC8Exosome component 8. (276 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa)
ORC6Origin recognition complex subunit 6. (293 aa)
RPAINRPA interacting protein. (209 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1601 aa)
AFF4AF4/FMR2 family member 4. (1112 aa)
TAF4BTATA-box binding protein associated factor 4b. (831 aa)
MLLT1MLLT1 super elongation complex subunit. (547 aa)
NCLNucleolin. (713 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
ICKIntestinal cell kinase. (632 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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