STRINGSTRING
Pou5f1 Pou5f1 CTNNB1 CTNNB1 ITGB1 ITGB1 SFRP2 SFRP2 SHH SHH IHH IHH TBX6 TBX6 HOXA13 HOXA13 EYA1 EYA1 SUFU SUFU SOX18 SOX18 MGA MGA SIX1 SIX1 TBX2 TBX2 FOXA2 FOXA2 GLI3 GLI3 TBX10 TBX10 TBX4 TBX4 PSEN1 PSEN1 GLI2 GLI2 NTRK3 NTRK3 TENM4 TENM4 TBX15 TBX15 TBX18 TBX18 POU1F1 POU1F1 PAX2 PAX2 FEV FEV MYL10 MYL10 TEAD4 TEAD4 ASCL1 ASCL1 APC2 APC2 FKBP8 FKBP8 GSC GSC TBX21 TBX21 OLIG3 OLIG3 DLL1 DLL1 DBX1 DBX1 Mnx1 Mnx1 PRDM14 PRDM14 NODAL NODAL SIX2 SIX2 TBX20 TBX20 EHMT2 EHMT2 TBX5 TBX5 MYT1L MYT1L Etv2 Etv2 SMO SMO PTCH2 PTCH2 TBX1 TBX1 TBX19 TBX19 SOX6 SOX6 HOXD10 HOXD10 MYL2 MYL2 ISL2 ISL2 HOXC10 HOXC10 H0VDD3_CAVPO H0VDD3_CAVPO PAX6 PAX6 LHX3 LHX3 RBPJ RBPJ DMRT3 DMRT3 H0V6I7_CAVPO H0V6I7_CAVPO GSX2 GSX2 ISL1 ISL1 CDON CDON EOMES EOMES TBX3 TBX3 OTX2 OTX2 PTCH1 PTCH1 DHH DHH PSEN2 PSEN2 APC APC TBXT TBXT HNF1B HNF1B SOX17 SOX17
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Pou5f1POU domain protein. (361 aa)
CTNNB1Catenin beta 1. (781 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
TBX6T-box transcription factor 6. (436 aa)
HOXA13Homeobox A13. (203 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)
SOX18SRY-box transcription factor 18. (375 aa)
MGAMAX dimerization protein MGA. (2990 aa)
SIX1SIX homeobox 1. (284 aa)
TBX2T-box transcription factor 2. (686 aa)
FOXA2Forkhead box A2. (459 aa)
GLI3GLI family zinc finger 3. (1580 aa)
TBX10T-box transcription factor 10. (380 aa)
TBX4T-box transcription factor 4. (452 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
GLI2GLI family zinc finger 2. (1570 aa)
NTRK3Tyrosine-protein kinase receptor. (864 aa)
TENM4Teneurin transmembrane protein 4. (2890 aa)
TBX15T-box transcription factor 15. (602 aa)
TBX18T-box transcription factor 18. (606 aa)
POU1F1POU domain protein. (316 aa)
PAX2Paired box 2. (393 aa)
FEVFEV transcription factor, ETS family member. (231 aa)
MYL10Myosin light chain 10. (147 aa)
TEAD4Transcriptional enhancer factor TEF-3; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. (450 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (215 aa)
APC2APC regulator of WNT signaling pathway 2. (2086 aa)
FKBP8Peptidylprolyl isomerase. (411 aa)
GSCGoosecoid homeobox. (228 aa)
TBX21T-box transcription factor 21. (388 aa)
OLIG3Oligodendrocyte transcription factor 3. (273 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
DBX1Developing brain homeobox 1. (336 aa)
Mnx1Homeobox domain-containing protein. (233 aa)
PRDM14PR/SET domain 14. (515 aa)
NODALNodal growth differentiation factor. (351 aa)
SIX2SIX homeobox 2. (298 aa)
TBX20T-box transcription factor 20. (446 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1188 aa)
TBX5T-box transcription factor 5. (518 aa)
MYT1LMyelin transcription factor 1 like. (1193 aa)
Etv2ETS domain-containing protein. (153 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
PTCH2Patched 2. (1207 aa)
TBX1T-box transcription factor 1. (360 aa)
TBX19T-box transcription factor 19. (446 aa)
SOX6SRY-box transcription factor 6. (859 aa)
HOXD10Homeobox D10. (340 aa)
MYL2Myosin light chain 2. (167 aa)
ISL2ISL LIM homeobox 2. (358 aa)
HOXC10Homeobox C10. (342 aa)
H0VDD3_CAVPOHomeobox domain-containing protein. (286 aa)
PAX6Paired box 6. (436 aa)
LHX3LIM homeobox 3. (403 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (518 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (471 aa)
H0V6I7_CAVPOUncharacterized protein. (231 aa)
GSX2GS homeobox 2. (293 aa)
ISL1ISL LIM homeobox 1. (349 aa)
CDONCell adhesion associated, oncogene regulated. (1265 aa)
EOMESEomesodermin. (697 aa)
TBX3T-box transcription factor 3. (739 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
PTCH1Patched 1. (1379 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
APCAPC regulator of WNT signaling pathway. (2842 aa)
TBXTT-box transcription factor T. (435 aa)
HNF1BHNF1 homeobox B. (558 aa)
SOX17SRY-box transcription factor 17. (400 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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