28 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DICER1	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily. (1903 aa)
	INTS1	Integrator complex subunit 1. (2212 aa)
	SETDB1	SET domain bifurcated histone lysine methyltransferase 1. (1290 aa)
	BRD4	Bromodomain containing 4. (1373 aa)
	GINS1	GINS complex subunit 1. (196 aa)
	Sall4	Uncharacterized protein. (272 aa)
	ESRRB	Estrogen related receptor beta. (454 aa)
	NCAPG2	Non-SMC condensin II complex subunit G2. (1168 aa)
	ENSCPOP00000030467	Uncharacterized protein. (127 aa)
	SBDS	SBDS ribosome maturation factor. (250 aa)
	ZNF830	Zinc finger protein 830. (363 aa)
	ZPR1	ZPR1 zinc finger. (459 aa)
	ENSCPOP00000025455	Protein kinase domain-containing protein. (360 aa)
	TAF8	TATA-box binding protein associated factor 8. (310 aa)
	GINS4	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa)
	Pou5f1	POU domain protein. (361 aa)
	PELO	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
	Chek1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa)
	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1636 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (751 aa)
	NDEL1	NudE neurodevelopment protein 1 like 1. (345 aa)
	RAD51B	RAD51 paralog B. (258 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (732 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	ACVR1C	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (479 aa)
	PALB2	Partner and localizer of BRCA2. (1172 aa)
	BRCA2	BRCA2 DNA repair associated. (3151 aa)
	COPS2	COP9 signalosome subunit 2. (443 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA2	Chek1	ENSCPOP00000004635	ENSCPOP00000014681	BRCA2 DNA repair associated.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.675
BRCA2	ENSCPOP00000025455	ENSCPOP00000004635	ENSCPOP00000025455	BRCA2 DNA repair associated.	Protein kinase domain-containing protein.	0.675
BRCA2	NBN	ENSCPOP00000004635	ENSCPOP00000012336	BRCA2 DNA repair associated.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.834
BRCA2	PALB2	ENSCPOP00000004635	ENSCPOP00000006213	BRCA2 DNA repair associated.	Partner and localizer of BRCA2.	0.999
BRCA2	RAD51B	ENSCPOP00000004635	ENSCPOP00000009649	BRCA2 DNA repair associated.	RAD51 paralog B.	0.984
BRD4	RTF1	ENSCPOP00000001274	ENSCPOP00000008401	Bromodomain containing 4.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.475
BRD4	SMARCA4	ENSCPOP00000001274	ENSCPOP00000014021	Bromodomain containing 4.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4.	0.782
BRD4	TAF8	ENSCPOP00000001274	ENSCPOP00000023432	Bromodomain containing 4.	TATA-box binding protein associated factor 8.	0.483
CTR9	INTS1	ENSCPOP00000008099	ENSCPOP00000001938	CTR9 homolog, Paf1/RNA polymerase II complex component.	Integrator complex subunit 1.	0.668
CTR9	RTF1	ENSCPOP00000008099	ENSCPOP00000008401	CTR9 homolog, Paf1/RNA polymerase II complex component.	RTF1 homolog, Paf1/RNA polymerase II complex component.	0.999
Chek1	BRCA2	ENSCPOP00000014681	ENSCPOP00000004635	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	BRCA2 DNA repair associated.	0.675
Chek1	GINS4	ENSCPOP00000014681	ENSCPOP00000022603	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.403
Chek1	NBN	ENSCPOP00000014681	ENSCPOP00000012336	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.687
Chek1	RAD51B	ENSCPOP00000014681	ENSCPOP00000009649	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	RAD51 paralog B.	0.818
DICER1	PALB2	ENSCPOP00000003807	ENSCPOP00000006213	Dicer 1, ribonuclease III; Belongs to the helicase family. Dicer subfamily.	Partner and localizer of BRCA2.	0.683
ENSCPOP00000025455	BRCA2	ENSCPOP00000025455	ENSCPOP00000004635	Protein kinase domain-containing protein.	BRCA2 DNA repair associated.	0.675
ENSCPOP00000025455	GINS4	ENSCPOP00000025455	ENSCPOP00000022603	Protein kinase domain-containing protein.	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family.	0.403
ENSCPOP00000025455	NBN	ENSCPOP00000025455	ENSCPOP00000012336	Protein kinase domain-containing protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.687
ENSCPOP00000025455	RAD51B	ENSCPOP00000025455	ENSCPOP00000009649	Protein kinase domain-containing protein.	RAD51 paralog B.	0.818
ENSCPOP00000030467	ESRRB	ENSCPOP00000030467	ENSCPOP00000031570	Uncharacterized protein.	Estrogen related receptor beta.	0.628