STRINGSTRING
ENSCPOP00000028528 ENSCPOP00000028528 ENSCPOP00000028064 ENSCPOP00000028064 IGF2 IGF2 SPINT1 SPINT1 HEY1 HEY1 KRT19 KRT19 LIF LIF FGFR2 FGFR2 TFEB TFEB AKT1 AKT1 PLK4 PLK4 GCM1 GCM1 HECTD1 HECTD1 BPTF BPTF WNT2 WNT2 NCOA1 NCOA1 VASH2 VASH2 LEF1 LEF1 TTPAL TTPAL ADM ADM HES1 HES1 HS6ST1 HS6ST1 HEY2 HEY2 RTL5 RTL5 SOCS3 SOCS3 SNAI1 SNAI1 CEBPB CEBPB Egln1 Egln1 SYDE1 SYDE1 Cebpa Cebpa CSF2 CSF2 HAND1 HAND1 JUNB JUNB NODAL NODAL PKD2 PKD2 EPAS1 EPAS1 PRDM1 PRDM1 H0VP65_CAVPO H0VP65_CAVPO BIRC6 BIRC6 TAF10 TAF10 GAB1 GAB1 PLG PLG ST14 ST14 NCOA6 NCOA6 STK3 STK3 VASH1 VASH1 CCN1 CCN1 GATA2 GATA2 GJB5 GJB5 ITGA4 ITGA4 SPINT2 SPINT2 SETD2 SETD2 NCOA3 NCOA3 E2F7 E2F7 PLCD3 PLCD3 RBPJ RBPJ VCAM1 VCAM1 PCDH12 PCDH12 Trim28 Trim28 GRHL2 GRHL2 FBXW8 FBXW8 PDGFB PDGFB HIF1A HIF1A H0V4A5_CAVPO H0V4A5_CAVPO SOX15 SOX15 LLGL2 LLGL2 EOMES EOMES Cited1 Cited1 TMED2 TMED2 CITED2 CITED2 PKD1 PKD1 MAP2K1 MAP2K1 SP3 SP3 NSDHL NSDHL Krt8 Krt8 H0UX36_CAVPO H0UX36_CAVPO PLCD1 PLCD1 EGFR EGFR RSPO3 RSPO3 GRB2 GRB2 ESRRB ESRRB TTPA TTPA GGNBP2 GGNBP2 NFE2 NFE2 OVOL2 OVOL2 MED1 MED1 ASCL2 ASCL2 ENSCPOP00000029626 ENSCPOP00000029626 ENSCPOP00000029567 ENSCPOP00000029567 ZFAT ZFAT BMP5 BMP5 E2F8 E2F8 IL10 IL10 HSF1 HSF1 BMP7 BMP7 STK4 STK4 MDFI MDFI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSCPOP00000028528IF rod domain-containing protein; Belongs to the intermediate filament family. (253 aa)
ENSCPOP00000028064IF rod domain-containing protein; Belongs to the intermediate filament family. (393 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
SPINT1Serine peptidase inhibitor, Kunitz type 1. (500 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (397 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
TFEBTranscription factor EB. (468 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLK4Polo like kinase 4. (958 aa)
GCM1Glial cells missing transcription factor 1. (439 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2505 aa)
BPTFBromodomain PHD finger transcription factor. (2851 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
NCOA1Nuclear receptor coactivator. (1442 aa)
VASH2Vasohibin 2. (355 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
TTPALAlpha tocopherol transfer protein like. (342 aa)
ADMAdrenomedullin. (182 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
HS6ST1Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (287 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (333 aa)
RTL5Retrotransposon Gag like 5. (608 aa)
SOCS3Suppressor of cytokine signaling 3. (228 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
CEBPBCCAAT enhancer binding protein beta. (216 aa)
Egln1Fe2OG dioxygenase domain-containing protein. (127 aa)
SYDE1Synapse defective Rho GTPase homolog 1. (723 aa)
CebpaUncharacterized protein. (158 aa)
CSF2Granulocyte-macrophage colony-stimulating factor; Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (145 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
NODALNodal growth differentiation factor. (351 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
EPAS1Endothelial PAS domain protein 1. (833 aa)
PRDM1PR/SET domain 1. (813 aa)
H0VP65_CAVPOIF rod domain-containing protein; Belongs to the intermediate filament family. (403 aa)
BIRC6Baculoviral IAP repeat containing 6. (4762 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (177 aa)
GAB1GRB2 associated binding protein 1. (751 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
ST14Suppressor of tumorigenicity 14 protein homolog; Degrades extracellular matrix. Belongs to the peptidase S1 family. (830 aa)
NCOA6Nuclear receptor coactivator 6. (2064 aa)
STK3Serine/threonine kinase 3. (463 aa)
VASH1Vasohibin 1. (368 aa)
CCN1Cellular communication network factor 1. (381 aa)
GATA2GATA binding protein 2. (374 aa)
GJB5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (273 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1021 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
NCOA3Nuclear receptor coactivator. (1418 aa)
E2F7E2F transcription factor 7. (904 aa)
PLCD3Phosphoinositide phospholipase C. (785 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (518 aa)
VCAM1Vascular cell adhesion molecule 1. (732 aa)
PCDH12Protocadherin 12. (984 aa)
Trim28Uncharacterized protein. (829 aa)
GRHL2Grainyhead like transcription factor 2. (620 aa)
FBXW8F-box and WD repeat domain containing 8. (584 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
H0V4A5_CAVPOUncharacterized protein. (830 aa)
SOX15SRY-box transcription factor 15. (216 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1017 aa)
EOMESEomesodermin. (697 aa)
Cited1Uncharacterized protein. (61 aa)
TMED2Transmembrane p24 trafficking protein 2. (208 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
SP3Sp3 transcription factor. (690 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
Krt8IF rod domain-containing protein; Belongs to the intermediate filament family. (474 aa)
H0UX36_CAVPOETS domain-containing protein. (131 aa)
PLCD1Phosphoinositide phospholipase C. (755 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
RSPO3R-spondin 3. (239 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
ESRRBEstrogen related receptor beta. (454 aa)
TTPAAlpha tocopherol transfer protein. (278 aa)
GGNBP2Gametogenetin binding protein 2. (738 aa)
NFE2Nuclear factor, erythroid 2. (373 aa)
OVOL2Ovo like zinc finger 2. (269 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (193 aa)
ENSCPOP00000029626Uncharacterized protein. (358 aa)
ENSCPOP00000029567IF rod domain-containing protein; Belongs to the intermediate filament family. (456 aa)
ZFATZinc finger and AT-hook domain containing. (1243 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
E2F8E2F transcription factor 8. (860 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
HSF1Heat shock transcription factor 1. (555 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
STK4Serine/threonine kinase 4. (487 aa)
MDFIMyoD family inhibitor. (246 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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