56 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PKD2	Polycystin 2, transient receptor potential cation channel. (839 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (409 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
	OVOL2	Ovo like zinc finger 2. (269 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1099 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	TBX20	T-box transcription factor 20. (446 aa)
	CCDC39	Coiled-coil domain containing 39. (678 aa)
	Nphp3	TPR_REGION domain-containing protein. (1281 aa)
	NOTCH2	Notch receptor 2. (2455 aa)
	NODAL	Nodal growth differentiation factor. (351 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (215 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
	SRF	Serum response factor. (461 aa)
	LBX1	Ladybird homeobox 1. (274 aa)
	NKX2-5	NK2 homeobox 5. (303 aa)
	IFT52	Intraflagellar transport 52. (406 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (607 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	CCDC103	Coiled-coil domain containing 103. (230 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
	FOLR1	Folate receptor alpha. (160 aa)
	KIF3A	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (606 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2326 aa)
	VANGL2	Vang-like protein. (548 aa)
	FOXH1	Forkhead box H1. (370 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	KDM2A	Lysine demethylase 2A. (1161 aa)
	CCDC40	Coiled-coil domain containing 40. (1120 aa)
	Gata4	Uncharacterized protein. (237 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (963 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (828 aa)
	TBX3	T-box transcription factor 3. (739 aa)
	H0V1U5_CAVPO	BMERB domain-containing protein. (622 aa)
	STIL	STIL centriolar assembly protein. (1049 aa)
	TMED2	Transmembrane p24 trafficking protein 2. (208 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (382 aa)
	ZIC3	Zic family member 3. (246 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (640 aa)
	CLUAP1	Clusterin associated protein 1. (432 aa)
	SOX17	SRY-box transcription factor 17. (400 aa)
	ENG	Endoglin. (653 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (381 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
	IFT172	Intraflagellar transport 172. (1749 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
	NOTO	Notochord homeobox. (210 aa)
	ENSCPOP00000025708	SH3 domain-containing protein. (146 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	LRP6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (484 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	C2CD3	ENSCPOP00000002327	ENSCPOP00000009605	ADP ribosylation factor like GTPase 13B.	C2 domain containing 3 centriole elongation regulator.	0.657
ARL13B	ENSCPOP00000025708	ENSCPOP00000002327	ENSCPOP00000025708	ADP ribosylation factor like GTPase 13B.	SH3 domain-containing protein.	0.562
ARL13B	IFT172	ENSCPOP00000002327	ENSCPOP00000024599	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 172.	0.570
ARL13B	IFT52	ENSCPOP00000002327	ENSCPOP00000016817	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.747
ARL13B	KIF3A	ENSCPOP00000002327	ENSCPOP00000010114	ADP ribosylation factor like GTPase 13B.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.656
ARL13B	Nphp3	ENSCPOP00000002327	ENSCPOP00000014191	ADP ribosylation factor like GTPase 13B.	TPR_REGION domain-containing protein.	0.649
ARL13B	PKD2	ENSCPOP00000002327	ENSCPOP00000013143	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.560
ARL13B	SHH	ENSCPOP00000002327	ENSCPOP00000031131	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.505
ARL13B	SMO	ENSCPOP00000002327	ENSCPOP00000011817	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.551
ARL13B	VANGL2	ENSCPOP00000002327	ENSCPOP00000009182	ADP ribosylation factor like GTPase 13B.	Vang-like protein.	0.490
ASB2	CLUAP1	ENSCPOP00000001976	ENSCPOP00000001362	Ankyrin repeat and SOCS box containing 2.	Clusterin associated protein 1.	0.558
ASB2	IFT172	ENSCPOP00000001976	ENSCPOP00000024599	Ankyrin repeat and SOCS box containing 2.	Intraflagellar transport 172.	0.585
ASB2	IFT52	ENSCPOP00000001976	ENSCPOP00000016817	Ankyrin repeat and SOCS box containing 2.	Intraflagellar transport 52.	0.606
ASB2	IFT57	ENSCPOP00000001976	ENSCPOP00000007286	Ankyrin repeat and SOCS box containing 2.	Intraflagellar transport 57.	0.586
C2CD3	ARL13B	ENSCPOP00000009605	ENSCPOP00000002327	C2 domain containing 3 centriole elongation regulator.	ADP ribosylation factor like GTPase 13B.	0.657
C2CD3	IFT172	ENSCPOP00000009605	ENSCPOP00000024599	C2 domain containing 3 centriole elongation regulator.	Intraflagellar transport 172.	0.655
CCDC103	CCDC39	ENSCPOP00000012136	ENSCPOP00000013800	Coiled-coil domain containing 103.	Coiled-coil domain containing 39.	0.740
CCDC103	CCDC40	ENSCPOP00000012136	ENSCPOP00000006286	Coiled-coil domain containing 103.	Coiled-coil domain containing 40.	0.739
CCDC103	DNAAF1	ENSCPOP00000012136	ENSCPOP00000009625	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.568
CCDC39	CCDC103	ENSCPOP00000013800	ENSCPOP00000012136	Coiled-coil domain containing 39.	Coiled-coil domain containing 103.	0.740