STRINGSTRING
TREX1 TREX1 NARF NARF MLF1 MLF1 AP3B1 AP3B1 FST FST TGFB1 TGFB1 COL24A1 COL24A1 SH2B3 SH2B3 PSEN2 PSEN2 PLD4 PLD4 KCNAB2 KCNAB2 SP3 SP3 LMBR1L LMBR1L ZBTB24 ZBTB24 CITED2 CITED2 PLEK PLEK LOC100725052 LOC100725052 Dact2 Dact2 MMP21 MMP21 KCP KCP HYAL2 HYAL2 ADAR ADAR Siglec10 Siglec10 CHD2 CHD2 SIN3A SIN3A ARMC6 ARMC6 JAM3 JAM3 AGPAT5 AGPAT5 TOP2A TOP2A BMP4 BMP4 SERPINB12 SERPINB12 UFL1 UFL1 FLT3 FLT3 FSTL3 FSTL3 TNFRSF13B TNFRSF13B FLT4 FLT4 ANLN ANLN WDR7 WDR7 DHTKD1 DHTKD1 THSD1 THSD1 GATA3 GATA3 LOC101787475 LOC101787475 GATA2 GATA2 KDR KDR CIAO3 CIAO3 HEATR9 HEATR9 ARHGEF7 ARHGEF7 KIT KIT LYN LYN PDGFRA PDGFRA EXT1 EXT1 FLT1 FLT1 H0VPC1_CAVPO H0VPC1_CAVPO PRKDC PRKDC H0VQ66_CAVPO H0VQ66_CAVPO H0VQE0_CAVPO H0VQE0_CAVPO LIG4 LIG4 TMEM190 TMEM190 DOCK1 DOCK1 EEF2 EEF2 BCL2 BCL2 CSF1R CSF1R SPI1 SPI1 SRF SRF XRCC4 XRCC4 SMPD3 SMPD3 BRAF BRAF TMEM91 TMEM91 CDK6 CDK6 SHH SHH EML1 EML1 ATF2 ATF2 BATF BATF PTPRQ PTPRQ TET2 TET2 TP53 TP53 SLC8A3 SLC8A3 ZFAT ZFAT ENSCPOP00000028778 ENSCPOP00000028778 PTPRC PTPRC RBM47 RBM47 STON2 STON2 SBDS SBDS KRT75 KRT75 ZNF784 ZNF784 ACP6 ACP6 BVES BVES KITLG KITLG SLC7A6OS SLC7A6OS PTPN6 PTPN6 SFRP1 SFRP1 SP7 SP7 DOCK7 DOCK7 C12orf29 C12orf29 PYGO1 PYGO1 PPP4R2 PPP4R2 Atf7 Atf7 ERCC2 ERCC2 XRCC5 XRCC5 PSEN1 PSEN1 SAMD9 SAMD9 Zswim9 Zswim9 ZFP36 ZFP36 PRRC2C PRRC2C TENT2 TENT2 PTPRZ1 PTPRZ1 SSBP3 SSBP3 Inhba Inhba ARL11 ARL11 SIPA1L3 SIPA1L3 SLC37A4 SLC37A4 SRSF4 SRSF4 ESCO2 ESCO2 RRS1 RRS1 SAMD9L SAMD9L Sox4 Sox4 TMEM143 TMEM143 H0W5D5_CAVPO H0W5D5_CAVPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TREX1Three prime repair exonuclease 1. (314 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (455 aa)
MLF1Myeloid leukemia factor 1. (329 aa)
AP3B1Adaptor related protein complex 3 subunit beta 1. (1276 aa)
FSTFollistatin. (344 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
COL24A1Collagen type XXIV alpha 1 chain. (1600 aa)
SH2B3SH2B adaptor protein 3. (557 aa)
PSEN2Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (448 aa)
PLD4Phospholipase D family member 4. (501 aa)
KCNAB2Potassium voltage-gated channel subfamily A regulatory beta subunit 2. (382 aa)
SP3Sp3 transcription factor. (690 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (488 aa)
ZBTB24Zinc finger and BTB domain containing 24. (698 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
PLEKPleckstrin. (350 aa)
LOC100725052Peptidase M60 domain-containing protein. (919 aa)
Dact2Uncharacterized protein. (668 aa)
MMP21Matrix metallopeptidase 21. (564 aa)
KCPKielin cysteine rich BMP regulator. (1526 aa)
HYAL2Hyaluronidase. (471 aa)
ADARAdenosine deaminase RNA specific. (1164 aa)
Siglec10Uncharacterized protein. (712 aa)
CHD2Uncharacterized protein. (1689 aa)
SIN3ASIN3 transcription regulator family member A. (1274 aa)
ARMC6Armadillo repeat containing 6. (468 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
AGPAT51-acylglycerol-3-phosphate O-acyltransferase 5. (338 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1540 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
SERPINB12Serpin family B member 12; Belongs to the serpin family. (424 aa)
UFL1UFM1 specific ligase 1. (762 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (987 aa)
FSTL3Follistatin like 3. (258 aa)
TNFRSF13BTNF receptor superfamily member 13B. (247 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1343 aa)
ANLNAnillin actin binding protein. (1133 aa)
WDR7WD repeat domain 7. (1453 aa)
DHTKD1Dehydrogenase E1 and transketolase domain containing 1. (920 aa)
THSD1Thrombospondin type 1 domain containing 1. (857 aa)
GATA3GATA binding protein 3. (443 aa)
LOC101787475Uncharacterized protein. (410 aa)
GATA2GATA binding protein 2. (374 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (476 aa)
HEATR9HEAT repeat containing 9. (567 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (753 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
LYNTyrosine-protein kinase. (512 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1332 aa)
H0VPC1_CAVPOG-patch domain-containing protein. (119 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa)
H0VQ66_CAVPOUncharacterized protein. (336 aa)
H0VQE0_CAVPOUncharacterized protein. (312 aa)
LIG4DNA ligase. (911 aa)
TMEM190Transmembrane protein 190. (171 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1865 aa)
EEF2Eukaryotic translation elongation factor 2. (815 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (979 aa)
SPI1Spi-1 proto-oncogene. (258 aa)
SRFSerum response factor. (461 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
TMEM91Transmembrane protein 91. (135 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
EML1EMAP like 1. (820 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
BATFBasic leucine zipper ATF-like transcription factor. (126 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2192 aa)
TET2Tet methylcytosine dioxygenase 2. (1863 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
ZFATZinc finger and AT-hook domain containing. (1243 aa)
ENSCPOP00000028778AHD domain-containing protein. (162 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1307 aa)
RBM47RNA binding motif protein 47. (592 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (894 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
KRT75Keratin 75; Belongs to the intermediate filament family. (552 aa)
ZNF784Zinc finger protein 784. (319 aa)
ACP6Acid phosphatase 6, lysophosphatidic; Belongs to the histidine acid phosphatase family. (428 aa)
BVESBlood vessel epicardial substance. (359 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (271 aa)
SLC7A6OSSolute carrier family 7 member 6 opposite strand. (305 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SFRP1Secreted frizzled related protein 1. (307 aa)
SP7Sp7 transcription factor. (428 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2006 aa)
C12orf29Chromosome 12 open reading frame 29. (315 aa)
PYGO1Pygopus family PHD finger 1. (443 aa)
PPP4R2Protein phosphatase 4 regulatory subunit 2. (416 aa)
Atf7Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (411 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
XRCC5X-ray repair cross complementing 5. (739 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (467 aa)
SAMD9Sterile alpha motif domain containing 9. (1570 aa)
Zswim9Uncharacterized protein. (446 aa)
ZFP36ZFP36 ring finger protein. (313 aa)
PRRC2CProline rich coiled-coil 2C. (2812 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (1433 aa)
SSBP3Single stranded DNA binding protein 3. (540 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
ARL11ADP ribosylation factor like GTPase 11; Belongs to the small GTPase superfamily. Arf family. (197 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1774 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
SRSF4Serine and arginine rich splicing factor 4. (497 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (597 aa)
RRS1Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (357 aa)
SAMD9LSterile alpha motif domain containing 9 like. (1532 aa)
Sox4HMG box domain-containing protein. (227 aa)
TMEM143Transmembrane protein 143. (459 aa)
H0W5D5_CAVPODUF4074 domain-containing protein. (324 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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