STRINGSTRING
RYR2 RYR2 RXRA RXRA APLNR APLNR ENG ENG MKS1 MKS1 FOXF1 FOXF1 TGFB1 TGFB1 SMAD6 SMAD6 DHRS3 DHRS3 RBP4 RBP4 SOS1 SOS1 TNNC1 TNNC1 CITED2 CITED2 DNAH11 DNAH11 TBX3 TBX3 NFATC1 NFATC1 NOS3 NOS3 EDNRA EDNRA ADGRG6 ADGRG6 HIF1A HIF1A Ahr Ahr GRHL2 GRHL2 ISL1 ISL1 Gata4 Gata4 SMAD4 SMAD4 BMP4 BMP4 RBPJ RBPJ MYH7 MYH7 TGFBR3 TGFBR3 NSD2 NSD2 TGFB2 TGFB2 NRG1 NRG1 DSP DSP FGFRL1 FGFRL1 GATA3 GATA3 ACVR1 ACVR1 NRP1 NRP1 IFT88 IFT88 WNT11 WNT11 FOXH1 FOXH1 TEK TEK ROBO1 ROBO1 CCN1 CCN1 VANGL2 VANGL2 MYL2 MYL2 DLL4 DLL4 SLIT3 SLIT3 PROX1 PROX1 PKP2 PKP2 TBX1 TBX1 MYL3 MYL3 COL11A1 COL11A1 SMO SMO SEMA3C SEMA3C CHD7 CHD7 ZFPM2 ZFPM2 TBX5 TBX5 TGFBR1 TGFBR1 TBX20 TBX20 CPE CPE SMARCA4 SMARCA4 PPP1R13L PPP1R13L NOTCH2 NOTCH2 ZFPM1 ZFPM1 HAND1 HAND1 FGF8 FGF8 SMARCD3 SMARCD3 SRF SRF SOX11 SOX11 ID2 ID2 TNNI3 TNNI3 NKX2-5 NKX2-5 Egln1 Egln1 TNNT2 TNNT2 ROBO2 ROBO2 H0W3X9_CAVPO H0W3X9_CAVPO H0W585_CAVPO H0W585_CAVPO Npy5r Npy5r FZD1 FZD1 BMPR1A BMPR1A Sox4 Sox4 GSK3A GSK3A FOXC2 FOXC2 MYL10 MYL10 GJA5 GJA5 HEY2 HEY2 BMP10 BMP10 MDM2 MDM2 HES1 HES1 TNNI1 TNNI1 MEF2C MEF2C NOG NOG DVL3 DVL3 PTCD2 PTCD2 UBE4B UBE4B ADPRHL1 ADPRHL1 Pitx2 Pitx2 SLIT2 SLIT2 WNT5A WNT5A WNT2 WNT2 ENSCPOP00000024297 ENSCPOP00000024297 ADAMTS1 ADAMTS1 NRP2 NRP2 LY6E LY6E SHOX2 SHOX2 SMAD7 SMAD7 Fkbp1a Fkbp1a ENSCPOP00000025309 ENSCPOP00000025309 MYBPC3 MYBPC3 HEYL HEYL TBX2 TBX2 TGFBR2 TGFBR2 FGFR2 FGFR2 HEY1 HEY1 NPY2R NPY2R PARVA PARVA BMP7 BMP7 BMPR2 BMPR2 FHL2 FHL2 SAV1 SAV1 TP53 TP53 MSX2 MSX2 FZD2 FZD2 MED1 MED1 OVOL2 OVOL2 HEG1 HEG1 BMP2 BMP2 CAV3 CAV3 SFRP2 SFRP2 MYH6 MYH6 JAG1 JAG1 HAND2 HAND2 BMP5 BMP5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYR2Ryanodine receptor 2. (4910 aa)
RXRARetinoid X receptor alpha. (459 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (381 aa)
ENGEndoglin. (653 aa)
MKS1MKS transition zone complex subunit 1. (558 aa)
FOXF1Forkhead box F1. (376 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SMAD6Mothers against decapentaplegic homolog. (508 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (304 aa)
RBP4Apolipoprotein D. (173 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1276 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
DNAH11Dynein axonemal heavy chain 11. (4501 aa)
TBX3T-box transcription factor 3. (739 aa)
NFATC1Nuclear factor of activated T cells 1. (928 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity); Belongs to the NOS family. (1206 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1168 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
AhrUncharacterized protein. (832 aa)
GRHL2Grainyhead like transcription factor 2. (620 aa)
ISL1ISL LIM homeobox 1. (349 aa)
Gata4Uncharacterized protein. (237 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (518 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1949 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1366 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (440 aa)
NRG1Neuregulin 1. (700 aa)
DSPDesmoplakin. (2805 aa)
FGFRL1Fibroblast growth factor receptor like 1. (488 aa)
GATA3GATA binding protein 3. (443 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (925 aa)
IFT88Intraflagellar transport 88. (825 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FOXH1Forkhead box H1. (370 aa)
TEKTEK receptor tyrosine kinase. (1029 aa)
ROBO1Roundabout guidance receptor 1. (1612 aa)
CCN1Cellular communication network factor 1. (381 aa)
VANGL2Vang-like protein. (548 aa)
MYL2Myosin light chain 2. (167 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
SLIT3Slit guidance ligand 3. (1517 aa)
PROX1Prospero homeobox 1. (737 aa)
PKP2Plakophilin 2. (835 aa)
TBX1T-box transcription factor 1. (360 aa)
MYL3Myosin light chain 3. (199 aa)
COL11A1Collagen type XI alpha 1 chain. (1712 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (787 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2996 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1079 aa)
TBX5T-box transcription factor 5. (518 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa)
TBX20T-box transcription factor 20. (446 aa)
CPECarboxypeptidase E. (476 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1636 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (781 aa)
NOTCH2Notch receptor 2. (2455 aa)
ZFPM1Zinc finger protein, FOG family member 1. (876 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (395 aa)
SRFSerum response factor. (461 aa)
SOX11Transcription factor SOX. (377 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
TNNI3Troponin I3, cardiac type. (211 aa)
NKX2-5NK2 homeobox 5. (303 aa)
Egln1Fe2OG dioxygenase domain-containing protein. (127 aa)
TNNT2Uncharacterized protein. (296 aa)
ROBO2Roundabout guidance receptor 2. (1509 aa)
H0W3X9_CAVPOUncharacterized protein. (2048 aa)
H0W585_CAVPOUncharacterized protein. (136 aa)
Npy5rNPY receptor 5. (446 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (634 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
Sox4HMG box domain-containing protein. (227 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
FOXC2Forkhead box C2. (441 aa)
MYL10Myosin light chain 10. (147 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (333 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
DVL3Dishevelled segment polarity protein 3. (717 aa)
PTCD2Pentatricopeptide repeat domain 2. (383 aa)
UBE4BUbiquitination factor E4B. (1347 aa)
ADPRHL1ADP-ribosylhydrolase like 1. (354 aa)
Pitx2Homeobox protein. (325 aa)
SLIT2Slit guidance ligand 2. (1391 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ENSCPOP00000024297Uncharacterized protein. (406 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (966 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (926 aa)
LY6ELymphocyte antigen 6 family member E. (136 aa)
SHOX2Short stature homeobox 2. (320 aa)
SMAD7SMAD family member 7. (221 aa)
Fkbp1aPeptidylprolyl isomerase. (108 aa)
ENSCPOP00000025309CCM2_C domain-containing protein. (147 aa)
MYBPC3Myosin binding protein C, cardiac. (1298 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
TBX2T-box transcription factor 2. (686 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (381 aa)
PARVAParvin alpha. (347 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
FHL2Four and a half LIM domains 2. (279 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
MSX2Msh homeobox 2. (267 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (551 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
OVOL2Ovo like zinc finger 2. (269 aa)
HEG1Heart development protein with EGF like domains 1. (1298 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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