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OGA OGA TRPM4 TRPM4 TBX5 TBX5 HCN3 HCN3 HCN1 HCN1 SCN10A SCN10A ABCD1 ABCD1 KDR KDR DCN DCN SCN5A SCN5A Hsh2d Hsh2d MLLT11 MLLT11 FHL1 FHL1 Ank3 Ank3 NEDD4L NEDD4L BOK BOK ENSCPOP00000024451 ENSCPOP00000024451 ENSCPOP00000024428 ENSCPOP00000024428 CCK CCK HCN2 HCN2 SCN1B SCN1B GJA5 GJA5 HCN4 HCN4 CACNA1G CACNA1G FGF12 FGF12 SLMAP SLMAP SCN2B SCN2B MYOC MYOC NPFF NPFF SCN3B SCN3B TSPO TSPO CAV3 CAV3 Camk2d Camk2d RANGRF RANGRF Parp1 Parp1 PTPN3 PTPN3 RACK1 RACK1 GOT1 GOT1 GCLC GCLC PPP2R3C PPP2R3C ALOX12 ALOX12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OGAO-GlcNAcase. (878 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4. (1138 aa)
TBX5T-box transcription factor 5. (518 aa)
HCN3Hyperpolarization activated cyclic nucleotide gated potassium channel 3. (780 aa)
HCN1Hyperpolarization activated cyclic nucleotide gated potassium channel 1. (671 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
ABCD1ATP binding cassette subfamily D member 1. (723 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
Hsh2dSH2 domain-containing protein. (356 aa)
MLLT11MLLT11 transcription factor 7 cofactor. (90 aa)
FHL1Four and a half LIM domains 1. (323 aa)
Ank3Uncharacterized protein. (1948 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (992 aa)
BOKBCL2 family apoptosis regulator BOK. (179 aa)
ENSCPOP00000024451Uncharacterized protein. (153 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
CCKCholecystokinin. (115 aa)
HCN2Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2. (783 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (216 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
HCN4Hyperpolarization activated cyclic nucleotide gated potassium channel 4. (1186 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
SLMAPSarcolemma associated protein. (845 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (209 aa)
MYOCMyocilin. (490 aa)
NPFFNeuropeptide FF-amide peptide precursor. (109 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (215 aa)
TSPOTranslocator protein. (169 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
RANGRFRAN guanine nucleotide release factor. (186 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (912 aa)
RACK1Receptor for activated C kinase 1. (317 aa)
GOT1Aspartate aminotransferase. (413 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (639 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (656 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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