31 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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protein homology

Your Input:
	H0W203_CAVPO	NAD(P)(+)--arginine ADP-ribosyltransferase. (297 aa)
	ART3	NAD(P)(+)--arginine ADP-ribosyltransferase. (370 aa)
	TNKS	Poly [ADP-ribose] polymerase. (1327 aa)
	ENSCPOP00000024428	PARP-type domain-containing protein. (104 aa)
	SIRT2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
	ART1	NAD(P)(+)--arginine ADP-ribosyltransferase. (336 aa)
	PARP14	Poly [ADP-ribose] polymerase. (1659 aa)
	VWA5B2	Von Willebrand factor A domain containing 5B2. (1204 aa)
	LOC100714269	NAD(P)(+)--arginine ADP-ribosyltransferase. (300 aa)
	PARP16	Poly [ADP-ribose] polymerase. (321 aa)
	PARP2	Poly [ADP-ribose] polymerase. (536 aa)
	ANKRD39	Ankyrin repeat domain 39. (183 aa)
	Parp9	Uncharacterized protein. (703 aa)
	Parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1702 aa)
	PARP10	Poly [ADP-ribose] polymerase. (945 aa)
	PARP8	Poly [ADP-ribose] polymerase. (879 aa)
	PARP3	Poly [ADP-ribose] polymerase. (533 aa)
	SIRT4	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
	PARP12	Poly(ADP-ribose) polymerase family member 12. (603 aa)
	PARP11	Poly [ADP-ribose] polymerase. (331 aa)
	ZC3HAV1	Zinc finger CCCH-type containing, antiviral 1. (899 aa)
	FAM162B	Family with sequence similarity 162 member B. (142 aa)
	FAM162A	Family with sequence similarity 162 member A. (155 aa)
	ART4	NAD(P)(+)--arginine ADP-ribosyltransferase. (328 aa)
	VWA5A	Von Willebrand factor A domain containing 5A. (798 aa)
	VWA5B1	Von Willebrand factor A domain containing 5B1. (1203 aa)
	TNKS2	Poly [ADP-ribose] polymerase. (1162 aa)
	PARP6	Poly [ADP-ribose] polymerase. (630 aa)
	TIPARP	TCDD inducible poly(ADP-ribose) polymerase. (657 aa)
	ART5	NAD(P)(+)--arginine ADP-ribosyltransferase. (309 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ART1	SIRT4	ENSCPOP00000022204	ENSCPOP00000011117	NAD(P)(+)--arginine ADP-ribosyltransferase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.451
ART4	SIRT4	ENSCPOP00000004716	ENSCPOP00000011117	NAD(P)(+)--arginine ADP-ribosyltransferase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.451
ART5	SIRT4	ENSCPOP00000000169	ENSCPOP00000011117	NAD(P)(+)--arginine ADP-ribosyltransferase.	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...]	0.422
ENSCPOP00000024428	PARP12	ENSCPOP00000024428	ENSCPOP00000010080	PARP-type domain-containing protein.	Poly(ADP-ribose) polymerase family member 12.	0.472
ENSCPOP00000024428	PARP14	ENSCPOP00000024428	ENSCPOP00000021248	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.451
ENSCPOP00000024428	PARP2	ENSCPOP00000024428	ENSCPOP00000018168	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.879
ENSCPOP00000024428	PARP3	ENSCPOP00000024428	ENSCPOP00000012500	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.862
ENSCPOP00000024428	PARP4	ENSCPOP00000024428	ENSCPOP00000013221	PARP-type domain-containing protein.	Poly [ADP-ribose] polymerase.	0.742
ENSCPOP00000024428	Parp9	ENSCPOP00000024428	ENSCPOP00000014715	PARP-type domain-containing protein.	Uncharacterized protein.	0.471
ENSCPOP00000024428	TIPARP	ENSCPOP00000024428	ENSCPOP00000000302	PARP-type domain-containing protein.	TCDD inducible poly(ADP-ribose) polymerase.	0.451
ENSCPOP00000024428	ZC3HAV1	ENSCPOP00000024428	ENSCPOP00000006948	PARP-type domain-containing protein.	Zinc finger CCCH-type containing, antiviral 1.	0.479
FAM162A	PARP14	ENSCPOP00000005151	ENSCPOP00000021248	Family with sequence similarity 162 member A.	Poly [ADP-ribose] polymerase.	0.537
FAM162A	PARP3	ENSCPOP00000005151	ENSCPOP00000012500	Family with sequence similarity 162 member A.	Poly [ADP-ribose] polymerase.	0.507
FAM162A	PARP4	ENSCPOP00000005151	ENSCPOP00000013221	Family with sequence similarity 162 member A.	Poly [ADP-ribose] polymerase.	0.486
PARP10	PARP16	ENSCPOP00000012825	ENSCPOP00000018660	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.577
PARP10	PARP2	ENSCPOP00000012825	ENSCPOP00000018168	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.693
PARP10	PARP3	ENSCPOP00000012825	ENSCPOP00000012500	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.658
PARP10	PARP4	ENSCPOP00000012825	ENSCPOP00000013221	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.668
PARP11	PARP2	ENSCPOP00000008784	ENSCPOP00000018168	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.494
PARP11	PARP3	ENSCPOP00000008784	ENSCPOP00000012500	Poly [ADP-ribose] polymerase.	Poly [ADP-ribose] polymerase.	0.493