STRINGSTRING
REN REN SOCS1 SOCS1 LOC100732158 LOC100732158 ARRB1 ARRB1 INS INS YWHAG YWHAG IGF2 IGF2 LOC100732436 LOC100732436 IGF1 IGF1 PIK3R1 PIK3R1 SOCS2 SOCS2 CRK CRK H0VE70_CAVPO H0VE70_CAVPO INSR INSR SHC1 SHC1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RENRenin; Belongs to the peptidase A1 family. (403 aa)
SOCS1Suppressor of cytokine signaling 1. (217 aa)
LOC100732158Uncharacterized protein. (246 aa)
ARRB1Arrestin beta 1. (430 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
YWHAGTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma; Belongs to the 14-3-3 family. (247 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (237 aa)
LOC100732436Uncharacterized protein. (327 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
SOCS2Suppressor of cytokine signaling 2. (198 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
INSRTyrosine-protein kinase receptor. (1371 aa)
SHC1SHC adaptor protein 1. (583 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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