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| | POLG2 | DNA polymerase gamma 2, accessory subunit. (482 aa) |
| | RBM48 | RNA binding motif protein 48. (364 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (834 aa) |
| | ATRX | ATRX chromatin remodeler. (2481 aa) |
| | TBRG1 | Transforming growth factor beta regulator 1. (411 aa) |
| | SAMHD1 | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (526 aa) |
| | GMNN | Geminin DNA replication inhibitor. (209 aa) |
| | MUS81 | MUS81 structure-specific endonuclease subunit. (562 aa) |
| | DNAJC2 | DnaJ heat shock protein family (Hsp40) member C2. (604 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (463 aa) |
| | DNAJA3 | DnaJ heat shock protein family (Hsp40) member A3. (479 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (419 aa) |
| | RRM2 | Ribonucleotide reductase regulatory subunit M2. (389 aa) |
| | RFC3 | Replication factor C subunit 3. (220 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | MCMBP | Minichromosome maintenance complex binding protein. (643 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (768 aa) |
| | H0VDT0_CAVPO | Protein kinase domain-containing protein. (337 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | MAML1 | Mastermind like transcriptional coactivator 1. (794 aa) |
| | NOC3L | Nucleolar complex protein 3 homolog. (800 aa) |
| | EXD2 | Exonuclease 3'-5' domain containing 2. (619 aa) |
| | NFIA | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (509 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (898 aa) |
| | RMI1 | RecQ mediated genome instability 1. (617 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa) |
| | Cdk9 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa) |
| | H0VGS2_CAVPO | Uncharacterized protein. (611 aa) |
| | KIN | Kin17 DNA and RNA binding protein. (393 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa) |
| | FBH1 | F-box DNA helicase 1. (1012 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | H0VJ90_CAVPO | Uncharacterized protein. (425 aa) |
| | CHAF1A | Chromatin assembly factor 1 subunit A. (949 aa) |
| | WDR18 | WD repeat domain 18. (429 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1831 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1523 aa) |
| | SMARCAL1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (938 aa) |
| | RBMS1 | RNA binding motif single stranded interacting protein 1. (404 aa) |
| | ING4 | Inhibitor of growth protein. (245 aa) |
| | RFC2 | Replication factor C subunit 2. (352 aa) |
| | ETAA1 | ETAA1 activator of ATR kinase. (866 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (568 aa) |
| | LIG3 | DNA ligase. (1012 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (798 aa) |
| | Ccne2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) |
| | HELB | DNA helicase B. (1063 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (706 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (453 aa) |
| | FHIT | Bis(5'-adenosyl)-triphosphatase. (150 aa) |
| | H0VSI3_CAVPO | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa) |
| | ORC3 | Origin recognition complex subunit 3. (710 aa) |
| | DDX21 | DExD-box helicase 21. (797 aa) |
| | RECQL4 | RecQ like helicase 4. (1226 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | Prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1109 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (650 aa) |
| | RFC5 | Replication factor C subunit 5. (340 aa) |
| | Rnaseh1 | Ribonuclease H1; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (294 aa) |
| | NFIX | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (474 aa) |
| | POLD2 | DNA polymerase delta 2, accessory subunit. (469 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (731 aa) |
| | DERPC | DERPC proline and glycine rich nuclear protein. (531 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (549 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (578 aa) |
| | NRM | Nurim. (203 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa) |
| | GMNC | Geminin coiled-coil domain containing. (341 aa) |
| | LOC100736130 | Uncharacterized protein. (287 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | MCM7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (116 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) |
| | Pold4 | Uncharacterized protein. (107 aa) |
| | POLE3 | DNA polymerase epsilon 3, accessory subunit. (147 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (223 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1021 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1738 aa) |
| | MMS22L | MMS22 like, DNA repair protein. (1237 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (916 aa) |
| | Cenpx | Uncharacterized protein. (79 aa) |
| | TIMELESS | Timeless circadian regulator. (1239 aa) |
| | ORC5 | Origin recognition complex subunit 5. (414 aa) |
| | GINS3 | GINS complex subunit 3. (216 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | ENSCPOP00000025543 | AAA_12 domain-containing protein. (243 aa) |
| | Tm4sf19 | Uncharacterized protein. (232 aa) |
| | CENPS | Centromere protein S. (135 aa) |
| | TK2 | Thymidine kinase 2. (264 aa) |
| | ZPR1 | ZPR1 zinc finger. (459 aa) |
| | RBBP7 | RB binding protein 7, chromatin remodeling factor. (469 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) |
| | GINS1 | GINS complex subunit 1. (196 aa) |
| | SSRP1 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa) |
| | RFWD3 | Ring finger and WD repeat domain 3. (764 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (810 aa) |
| | TWNK | Twinkle mtDNA helicase. (670 aa) |
| | THOC1 | THO complex 1. (657 aa) |
| | SRPK2 | SRSF protein kinase 2. (688 aa) |
| | LRWD1 | Leucine rich repeats and WD repeat domain containing 1. (642 aa) |
| | FANCM | FA complementation group M. (1971 aa) |
| | POLN | DNA polymerase nu. (860 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa) |
| | SIRT7 | Sirtuin 7. (401 aa) |
| | Pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (598 aa) |
| | E4F1 | E4F transcription factor 1. (780 aa) |
| | DDX50 | DExD-box helicase 50. (735 aa) |
| | POLA1 | DNA polymerase. (1467 aa) |
| | SUPT16H | SPT16 homolog, facilitates chromatin remodeling subunit. (887 aa) |
| | ALYREF | Aly/REF export factor. (256 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1392 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (547 aa) |
| | ENSCPOP00000027449 | Uncharacterized protein. (313 aa) |
| | ZNF830 | Zinc finger protein 830. (363 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (371 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (351 aa) |
| | RTF2 | Replication termination factor 2. (308 aa) |
| | FAM111A | Family with sequence similarity 111 member A. (597 aa) |
| | MGME1 | Mitochondrial genome maintenance exonuclease 1; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA- primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair; Belongs to the MGME1 family. (356 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | ENSCPOP00000030705 | CYCLIN domain-containing protein; Belongs to the cyclin family. (341 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa) |
| | TOP1MT | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (629 aa) |
| | REPIN1 | Replication initiator 1. (612 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | ING5 | Inhibitor of growth protein. (213 aa) |
| | TONSL | Tonsoku like, DNA repair protein. (1395 aa) |
| | Pclaf | PAF domain-containing protein. (112 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | DDX23 | DEAD-box helicase 23. (819 aa) |
| | SSBP1 | Single stranded DNA binding protein 1. (137 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1118 aa) |
| | TRAIP | TRAF interacting protein. (469 aa) |
| | RPAIN | RPA interacting protein. (209 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (863 aa) |
| | ORC6 | Origin recognition complex subunit 6. (293 aa) |
| | DDX11 | DEAD/H-box helicase 11. (878 aa) |
| | PRIM2 | DNA primase subunit 2. (432 aa) |
| | NFIB | Nuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (494 aa) |
| | Lig1 | DNA ligase. (909 aa) |
| | RFC1 | Replication factor C subunit 1. (1153 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ORC2 | Origin recognition complex subunit 2. (577 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (821 aa) |
| | CCNE1 | Cyclin E1; Belongs to the cyclin family. (410 aa) |
| | DONSON | Downstream neighbor of SON. (553 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (837 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3151 aa) |
| | MCM9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | TTC38 | Tetratricopeptide repeat domain 38. (468 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | POLG | DNA polymerase gamma, catalytic subunit. (1206 aa) |
