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| | SIRT1 | Sirtuin 1. (717 aa) |
| | KLHL15 | Kelch like family member 15. (604 aa) |
| | ENSCPOP00000033122 | MPN domain-containing protein. (250 aa) |
| | ACTL6A | Actin like 6A; Belongs to the actin family. (429 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (719 aa) |
| | DEK | DEK proto-oncogene. (374 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (449 aa) |
| | LOC100722203 | BZIP domain-containing protein. (150 aa) |
| | HSF1 | Heat shock transcription factor 1. (555 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | NUDT16L1 | Nudix hydrolase 16 like 1. (211 aa) |
| | IER3 | Immediate early response 3. (152 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (629 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1473 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa) |
| | POT1 | Protection of telomeres 1. (652 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (334 aa) |
| | POGZ | Pogo transposable element derived with ZNF domain. (1412 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa) |
| | Morf4l1 | Mortality factor 4 like 1. (377 aa) |
| | RMI2 | RecQ mediated genome instability 2. (147 aa) |
| | ENSCPOP00000029431 | Uncharacterized protein. (111 aa) |
| | MBTD1 | Mbt domain containing 1. (627 aa) |
| | DHX9 | DExH-box helicase 9. (1373 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (244 aa) |
| | SHLD1 | Shieldin complex subunit 1. (216 aa) |
| | ARID2 | AT-rich interaction domain 2. (1763 aa) |
| | EP400 | E1A binding protein p400. (3128 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (202 aa) |
| | FUS | FUS RNA binding protein. (490 aa) |
| | Rps3 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa) |
| | ENSCPOP00000028155 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (102 aa) |
| | HDGFL2 | HDGF like 2. (666 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (171 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1027 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (145 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (358 aa) |
| | INO80C | INO80 complex subunit C. (192 aa) |
| | ENSCPOP00000027005 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (83 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (639 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (416 aa) |
| | ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | ENSCPOP00000024875 | MRG domain-containing protein. (231 aa) |
| | CBX8 | Chromobox 8. (389 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (188 aa) |
| | ENSCPOP00000024582 | MRG domain-containing protein. (291 aa) |
| | WDR48 | WD repeat domain 48. (676 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (625 aa) |
| | ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa) |
| | TRRAP | Transformation/transcription domain associated protein; Belongs to the PI3/PI4-kinase family. (3860 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (291 aa) |
| | KMT5B | Lysine methyltransferase 5B. (882 aa) |
| | TIMELESS | Timeless circadian regulator. (1239 aa) |
| | ENSCPOP00000023362 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | FH | Fumarate hydratase. (508 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2387 aa) |
| | ENSCPOP00000022509 | Uncharacterized protein. (140 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (208 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | ACTR2 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (989 aa) |
| | OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa) |
| | LOC100736130 | Uncharacterized protein. (287 aa) |
| | MRGBP | MRG domain binding protein. (204 aa) |
| | TADA1 | Transcriptional adaptor 1. (310 aa) |
| | FIGNL1 | Fidgetin like 1; Belongs to the AAA ATPase family. (676 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (351 aa) |
| | OTUB1 | Ubiquitin thioesterase. (271 aa) |
| | VPS72 | Vacuolar protein sorting 72 homolog. (364 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa) |
| | CYREN | Cell cycle regulator of NHEJ. (180 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (211 aa) |
| | Yy1 | Uncharacterized protein. (195 aa) |
| | TERF2IP | TERF2 interacting protein. (371 aa) |
| | DMAP1 | DNA methyltransferase 1 associated protein 1. (445 aa) |
| | WAS | WASP actin nucleation promoting factor. (505 aa) |
| | H0VYV4_CAVPO | Uncharacterized protein. (260 aa) |
| | H0VYM4_CAVPO | Uncharacterized protein. (503 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (764 aa) |
| | APBB1 | Amyloid beta precursor protein binding family B member 1. (709 aa) |
| | Parp9 | Uncharacterized protein. (703 aa) |
| | Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) |
| | RNF169 | Ring finger protein 169. (699 aa) |
| | Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | FOXM1 | Forkhead box M1. (762 aa) |
| | H0VS04_CAVPO | Hist_deacetyl domain-containing protein. (286 aa) |
| | Rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1246 aa) |
| | PARG | Poly(ADP-ribose) glycohydrolase. (973 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4043 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (533 aa) |
| | HELB | DNA helicase B. (1063 aa) |
| | TMEM161A | Transmembrane protein 161A. (474 aa) |
| | Brca1 | Uncharacterized protein. (79 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (529 aa) |
| | H0VN16_CAVPO | Uncharacterized protein. (71 aa) |
| | LOC106026468 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (174 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (568 aa) |
| | Ino80b | PAPA-1 domain-containing protein. (373 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (497 aa) |
| | INO80E | INO80 complex subunit E. (244 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (602 aa) |
| | TFPT | TCF3 fusion partner. (257 aa) |
| | INO80 | INO80 complex ATPase subunit. (1558 aa) |
| | MCRS1 | Microspherule protein 1. (462 aa) |
| | PPP4R3B | Protein phosphatase 4 regulatory subunit 3B. (802 aa) |
| | H0VI45_CAVPO | zf-C3Hc3H domain-containing protein. (414 aa) |
| | Cgas | Mab-21 domain-containing protein. (387 aa) |
| | FBH1 | F-box DNA helicase 1. (1012 aa) |
| | Cdk9 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa) |
| | UIMC1 | Ubiquitin interaction motif containing 1. (716 aa) |
| | PARPBP | PARP1 binding protein. (577 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (265 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2649 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | HELQ | Helicase, POLQ like. (1054 aa) |
| | KMT5C | Lysine methyltransferase 5C. (476 aa) |
| | H0VDT0_CAVPO | Protein kinase domain-containing protein. (337 aa) |
| | OGG1 | 8-oxoguanine DNA glycosylase. (303 aa) |
| | RPA2 | Replication protein A2. (270 aa) |
| | EPC2 | Enhancer of polycomb homolog. (803 aa) |
| | BRD8 | Bromodomain containing 8. (951 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2565 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (1959 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (278 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (900 aa) |
| | ZNF365 | Zinc finger protein 365. (398 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1366 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | Babam1 | Uncharacterized protein. (337 aa) |
| | KDM4D | Lysine demethylase 4D. (512 aa) |
| | Trim28 | Uncharacterized protein. (829 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (523 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1061 aa) |
| | H0V4A5_CAVPO | Uncharacterized protein. (830 aa) |
| | Ercc8 | WD_REPEATS_REGION domain-containing protein. (396 aa) |
| | AXIN2 | Axin 2. (802 aa) |
| | DDX11 | DEAD/H-box helicase 11. (878 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (541 aa) |
| | EPC1 | Enhancer of polycomb homolog 1. (763 aa) |
| | UBQLN4 | Ubiquilin 4. (593 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (514 aa) |
| | SIRT7 | Sirtuin 7. (401 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (612 aa) |
| | H0UX17_CAVPO | BRCT domain-containing protein. (722 aa) |
| | BLM | BLM RecQ like helicase. (1405 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1945 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (371 aa) |
| | PML | Promyelocytic leukemia. (849 aa) |
| | SHLD2 | Shieldin complex subunit 2. (905 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1141 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (280 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase. (324 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1298 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (717 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
