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UNG-2 | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa) | ||||
RPA3 | Replication protein A3. (121 aa) | ||||
MPG | N-methylpurine DNA glycosylase. (300 aa) | ||||
ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1473 aa) | ||||
RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) | ||||
TDG | Thymine DNA glycosylase. (413 aa) | ||||
ERCC5 | ERCC excision repair 5, endonuclease. (1059 aa) | ||||
XPA | XPA, DNA damage recognition and repair factor. (263 aa) | ||||
WRN | WRN RecQ like helicase. (1462 aa) | ||||
NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa) | ||||
NEIL3 | Nei like DNA glycosylase 3. (607 aa) | ||||
Lig1 | DNA ligase. (909 aa) | ||||
POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa) | ||||
NEIL2 | Nei like DNA glycosylase 2. (336 aa) | ||||
USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) | ||||
APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa) | ||||
XRCC1 | X-ray repair cross complementing 1. (629 aa) | ||||
HMGA1 | High mobility group AT-hook 1. (108 aa) | ||||
APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa) | ||||
FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) | ||||
SMUG1 | Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa) | ||||
POLG | DNA polymerase gamma, catalytic subunit. (1206 aa) | ||||
RPA2 | Replication protein A2. (270 aa) | ||||
OGG1 | 8-oxoguanine DNA glycosylase. (303 aa) | ||||
PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) | ||||
POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa) | ||||
NEIL1 | Nei like DNA glycosylase 1. (401 aa) | ||||
Mutyh | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa) | ||||
LIG3 | DNA ligase. (1012 aa) | ||||
H0VN16_CAVPO | Uncharacterized protein. (71 aa) | ||||
POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa) | ||||
H0VSI3_CAVPO | DNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa) | ||||
Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) | ||||
PARP2 | Poly [ADP-ribose] polymerase. (536 aa) | ||||
UNG | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa) | ||||
POLD1 | DNA polymerase. (1134 aa) | ||||
Bivm | Uncharacterized protein. (503 aa) | ||||
DNA2 | DNA replication helicase/nuclease 2. (1021 aa) | ||||
ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) |