STRINGSTRING
UNG-2 UNG-2 RPA3 RPA3 MPG MPG ERCC6 ERCC6 RPA1 RPA1 TDG TDG ERCC5 ERCC5 XPA XPA WRN WRN NTHL1 NTHL1 NEIL3 NEIL3 Lig1 Lig1 POLL POLL NEIL2 NEIL2 USP47 USP47 APEX2 APEX2 XRCC1 XRCC1 HMGA1 HMGA1 APEX1 APEX1 FEN1 FEN1 SMUG1 SMUG1 POLG POLG RPA2 RPA2 OGG1 OGG1 PCNA PCNA POLB POLB NEIL1 NEIL1 Mutyh Mutyh LIG3 LIG3 H0VN16_CAVPO H0VN16_CAVPO POLE POLE H0VSI3_CAVPO H0VSI3_CAVPO Parp1 Parp1 PARP2 PARP2 UNG UNG POLD1 POLD1 Bivm Bivm DNA2 DNA2 ENSCPOP00000024428 ENSCPOP00000024428
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
UNG-2Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (311 aa)
RPA3Replication protein A3. (121 aa)
MPGN-methylpurine DNA glycosylase. (300 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
TDGThymine DNA glycosylase. (413 aa)
ERCC5ERCC excision repair 5, endonuclease. (1059 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
WRNWRN RecQ like helicase. (1462 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa)
NEIL3Nei like DNA glycosylase 3. (607 aa)
Lig1DNA ligase. (909 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
NEIL2Nei like DNA glycosylase 2. (336 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa)
APEX2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (514 aa)
XRCC1X-ray repair cross complementing 1. (629 aa)
HMGA1High mobility group AT-hook 1. (108 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
SMUG1Single-strand-selective monofunctional uracil-DNA glycosylase 1. (272 aa)
POLGDNA polymerase gamma, catalytic subunit. (1206 aa)
RPA2Replication protein A2. (270 aa)
OGG18-oxoguanine DNA glycosylase. (303 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (340 aa)
NEIL1Nei like DNA glycosylase 1. (401 aa)
MutyhAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa)
LIG3DNA ligase. (1012 aa)
H0VN16_CAVPOUncharacterized protein. (71 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
H0VSI3_CAVPODNA_LIGASE_A3 domain-containing protein; Belongs to the ATP-dependent DNA ligase family. (677 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (298 aa)
POLD1DNA polymerase. (1134 aa)
BivmUncharacterized protein. (503 aa)
DNA2DNA replication helicase/nuclease 2. (1021 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
Server load: low (32%) [HD]