STRINGSTRING
H0VPN0_CAVPO H0VPN0_CAVPO DCLRE1A DCLRE1A LIG4 LIG4 MNAT1 MNAT1 H0VSL9_CAVPO H0VSL9_CAVPO CETN1 CETN1 H0W9J0_CAVPO H0W9J0_CAVPO LOC100732574 LOC100732574 ERCC2 ERCC2 RAD23B RAD23B SLX4 SLX4 HUS1 HUS1 Bivm Bivm POLD1 POLD1 GTF2H4 GTF2H4 GTF2H1 GTF2H1 KAT5 KAT5 ENSCPOP00000022087 ENSCPOP00000022087 ERCC5 ERCC5 XPA XPA COMMD1 COMMD1 ERCC3 ERCC3 USP7 USP7 NTHL1 NTHL1 ERCC1 ERCC1 FANCC FANCC ERCC6 ERCC6 TP53 TP53 ENSCPOP00000029727 ENSCPOP00000029727 GTF2H5 GTF2H5 HMGN1 HMGN1 RAD23A RAD23A RPA3 RPA3 RPA1 RPA1 SIRT1 SIRT1 POLK POLK ERCC4 ERCC4 Ercc8 Ercc8 BRCA2 BRCA2 POLL POLL H0V698_CAVPO H0V698_CAVPO XPC XPC Pold3 Pold3 RPA2 RPA2 OGG1 OGG1 H0VDH6_CAVPO H0VDH6_CAVPO XAB2 XAB2 GTF2H3 GTF2H3 BRIP1 BRIP1 Cetn2 Cetn2 POLR2I POLR2I FAN1 FAN1 DDB2 DDB2 POLE POLE UVSSA UVSSA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
H0VPN0_CAVPOC1_4 domain-containing protein. (286 aa)
DCLRE1ADNA cross-link repair 1A. (913 aa)
LIG4DNA ligase. (911 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
H0VSL9_CAVPOSsl1 domain-containing protein. (160 aa)
CETN1Centrin 1. (172 aa)
H0W9J0_CAVPOUncharacterized protein. (147 aa)
LOC100732574General transcription factor IIH subunit. (395 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (409 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1738 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (282 aa)
BivmUncharacterized protein. (503 aa)
POLD1DNA polymerase. (1134 aa)
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (485 aa)
GTF2H1General transcription factor IIH subunit 1. (556 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
ENSCPOP00000022087Uncharacterized protein. (161 aa)
ERCC5ERCC excision repair 5, endonuclease. (1059 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1101 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (260 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (569 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1473 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
ENSCPOP00000029727C1_4 domain-containing protein. (309 aa)
GTF2H5General transcription factor IIH subunit 5. (71 aa)
HMGN1High mobility group nucleosome binding domain 1. (130 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
RPA3Replication protein A3. (121 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
SIRT1Sirtuin 1. (717 aa)
POLKDNA polymerase kappa. (540 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
Ercc8WD_REPEATS_REGION domain-containing protein. (396 aa)
BRCA2BRCA2 DNA repair associated. (3151 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (594 aa)
H0V698_CAVPOC2H2-type domain-containing protein. (374 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
Pold3Uncharacterized protein. (466 aa)
RPA2Replication protein A2. (270 aa)
OGG18-oxoguanine DNA glycosylase. (303 aa)
H0VDH6_CAVPOVWFA domain-containing protein. (365 aa)
XAB2XPA binding protein 2. (855 aa)
GTF2H3General transcription factor IIH subunit 3. (309 aa)
BRIP1BRCA1 interacting protein C-terminal helicase 1. (971 aa)
Cetn2Uncharacterized protein. (172 aa)
POLR2IDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa)
FAN1Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (987 aa)
DDB2Damage specific DNA binding protein 2. (289 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
UVSSAUV stimulated scaffold protein A. (730 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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