STRINGSTRING
RPA1 RPA1 ERCC1 ERCC1 RNASEH2A RNASEH2A RPA3 RPA3 PMS1 PMS1 MLH3 MLH3 MSH2 MSH2 Mutyh Mutyh MSH3 MSH3 PCNA PCNA RPA2 RPA2 SETD2 SETD2 XPC XPC MCM9 MCM9 MLH1 MLH1 MSH4 MSH4 MSH6 MSH6 Msh5 Msh5 PMS2 PMS2 EXO1 EXO1 TDG TDG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa)
RNASEH2ARibonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (298 aa)
RPA3Replication protein A3. (121 aa)
PMS1PMS1 homolog 1, mismatch repair system component. (930 aa)
MLH3MutL homolog 3. (1455 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
MutyhAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (530 aa)
MSH3MutS homolog 3. (1047 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RPA2Replication protein A2. (270 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (923 aa)
MCM9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1117 aa)
MLH1MutL homolog 1. (758 aa)
MSH4DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (884 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa)
Msh5DNA_MISMATCH_REPAIR_2 domain-containing protein. (828 aa)
PMS2PMS1 homolog 2, mismatch repair system component. (890 aa)
EXO1Exonuclease 1. (839 aa)
TDGThymine DNA glycosylase. (413 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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