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| | TENT4B | Terminal nucleotidyltransferase 4B. (673 aa) |
| | AGO4 | Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (848 aa) |
| | DCP1A | Decapping mRNA 1A. (601 aa) |
| | SMG9 | SMG9 nonsense mediated mRNA decay factor. (520 aa) |
| | CTIF | Cap binding complex dependent translation initiation factor. (612 aa) |
| | SKIV2L | Ski2 like RNA helicase. (1239 aa) |
| | PDE12 | Phosphodiesterase 12. (608 aa) |
| | DCP2 | Decapping mRNA 2. (422 aa) |
| | ETF1 | Eukaryotic translation termination factor 1. (437 aa) |
| | TUT7 | Terminal uridylyl transferase 7. (1514 aa) |
| | METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (553 aa) |
| | POLR2D | RNA polymerase II subunit D. (142 aa) |
| | NUDT12 | Nudix hydrolase 12. (462 aa) |
| | SMG8 | SMG8 nonsense mediated mRNA decay factor. (988 aa) |
| | PATL2 | PAT1 homolog 2. (517 aa) |
| | NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa) |
| | LRRC27 | Leucine rich repeat containing 27. (508 aa) |
| | Xrn1 | 5'-3' exoribonuclease 1. (1386 aa) |
| | CNOT8 | CCR4-NOT transcription complex subunit 8. (292 aa) |
| | NOCT | Nocturnin. (432 aa) |
| | MLH1 | MutL homolog 1. (758 aa) |
| | MTPAP | Mitochondrial poly(A) polymerase. (627 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1116 aa) |
| | EXOSC8 | Exosome component 8. (276 aa) |
| | CNOT2 | CCR4-NOT transcription complex subunit 2. (544 aa) |
| | EXOSC7 | Exosome component 7. (291 aa) |
| | TUT4 | Terminal uridylyl transferase 4. (1584 aa) |
| | KHSRP | KH-type splicing regulatory protein. (726 aa) |
| | DIS3L2 | DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (877 aa) |
| | DCP1B | Decapping mRNA 1B. (592 aa) |
| | SAMD4B | Sterile alpha motif domain containing 4B. (692 aa) |
| | CNOT10 | CCR4-NOT transcription complex subunit 10. (754 aa) |
| | SND1 | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. (910 aa) |
| | UPF3A | UPF3A regulator of nonsense mediated mRNA decay. (430 aa) |
| | PATL1 | PAT1 homolog 1, processing body mRNA decay factor. (790 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa) |
| | PYM1 | PYM homolog 1, exon junction complex associated factor. (203 aa) |
| | LOC100718706 | Nudix hydrolase domain-containing protein. (194 aa) |
| | RC3H2 | Ring finger and CCCH-type domains 2. (1188 aa) |
| | Lsm4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa) |
| | POLR2G | RNA polymerase II subunit G. (172 aa) |
| | CNOT11 | CCR4-NOT transcription complex subunit 11. (515 aa) |
| | MAGOH | Mago homolog, exon junction complex subunit. (146 aa) |
| | LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa) |
| | CSDE1 | Cold shock domain-containing protein E1; RNA-binding protein. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (By similarity). (779 aa) |
| | EXOSC10 | Exosome component 10. (901 aa) |
| | PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (751 aa) |
| | LSM1 | U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa) |
| | EIF4A3 | Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa) |
| | ENSCPOP00000030021 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (537 aa) |
| | METTL14 | Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa) |
| | PNRC2 | Proline rich nuclear receptor coactivator 2. (139 aa) |
| | LOC100728313 | RNase_PH domain-containing protein. (256 aa) |
| | EXOSC2 | Exosome component 2. (293 aa) |
| | RIDA | Reactive intermediate imine deaminase A homolog. (137 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (338 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (550 aa) |
| | NBDY | Negative regulator of P-body association. (67 aa) |
| | CASC3 | CASC3 exon junction complex subunit. (698 aa) |
| | LSM6 | LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa) |
| | AGO1 | Argonaute RISC component 1; Belongs to the argonaute family. (857 aa) |
| | SSB | Small RNA binding exonuclease protection factor La. (405 aa) |
| | MRTO4 | Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (241 aa) |
| | DHX34 | DExH-box helicase 34. (1183 aa) |
| | SMG7 | SMG7 nonsense mediated mRNA decay factor. (1165 aa) |
| | RNPS1 | RNA binding protein with serine rich domain 1. (305 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | UPF2 | UPF2 regulator of nonsense mediated mRNA decay. (1252 aa) |
| | GSPT1 | G1 to S phase transition 1. (561 aa) |
| | XRN2 | 5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (950 aa) |
| | SUPV3L1 | Suv3 like RNA helicase. (786 aa) |
| | EXOSC5 | Exosome component 5. (240 aa) |
| | CNOT9 | CCR4-NOT transcription complex subunit 9. (299 aa) |
| | CNOT6 | CCR4-NOT transcription complex subunit 6. (534 aa) |
| | ZFP36 | ZFP36 ring finger protein. (313 aa) |
| | EDC4 | Enhancer of mRNA decapping 4. (1405 aa) |
| | EXOSC9 | Exosome component 9. (439 aa) |
| | TENT2 | Terminal nucleotidyltransferase 2. (484 aa) |
| | CNOT3 | CCR4-NOT transcription complex subunit 3. (751 aa) |
| | Exosc6 | RNase_PH domain-containing protein. (246 aa) |
| | ENSCPOP00000023532 | XRN_N domain-containing protein. (103 aa) |
| | CNOT7 | CCR4-NOT transcription complex subunit 7. (285 aa) |
| | METTL16 | U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (552 aa) |
| | AGO3 | Argonaute RISC catalytic component 3; Belongs to the argonaute family. (827 aa) |
| | PARN | Poly(A)-specific ribonuclease. (637 aa) |
| | LOC100717205 | Uncharacterized protein; Belongs to the heat shock protein 70 family. (641 aa) |
| | ZHX2 | Zinc fingers and homeoboxes 2. (836 aa) |
| | EXOSC4 | Exosome component 4. (245 aa) |
| | PABPN1L | Poly(A) binding protein nuclear 1 like, cytoplasmic. (273 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (403 aa) |
| | LOC100718426 | Uncharacterized protein. (152 aa) |
| | RBM8A | RNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (171 aa) |
| | LSM2 | U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1109 aa) |
| | PNLDC1 | PARN like, ribonuclease domain containing 1. (518 aa) |
| | GTPBP2 | GTP binding protein 2. (602 aa) |
| | THRAP3 | Thyroid hormone receptor associated protein 3. (953 aa) |
| | SMG5 | SMG5 nonsense mediated mRNA decay factor. (1018 aa) |
| | EDC3 | Enhancer of mRNA decapping 3. (508 aa) |
| | DXO | Decapping exoribonuclease. (397 aa) |
| | PNPT1 | Polyribonucleotide nucleotidyltransferase 1. (783 aa) |
| | NANOS2 | Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (130 aa) |
| | PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1204 aa) |
| | SMG6 | SMG6 nonsense mediated mRNA decay factor. (1420 aa) |
| | SAMD4A | Sterile alpha motif domain containing 4A. (714 aa) |
| | ZC3H12D | Zinc finger CCCH-type containing 12D. (464 aa) |
| | DCPS | Decapping enzyme, scavenger. (337 aa) |
| | CNOT6L | CCR4-NOT transcription complex subunit 6 like. (462 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa) |
| | SWT1 | SWT1 RNA endoribonuclease homolog. (830 aa) |
| | LSM7 | LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (103 aa) |
| | TTC37 | Tetratricopeptide repeat domain 37. (1595 aa) |
| | ZCCHC7 | Zinc finger CCHC-type containing 7. (564 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2294 aa) |
| | MAGOHB | Mago homolog B, exon junction complex subunit. (102 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3632 aa) |
| | NCBP1 | Nuclear cap binding protein subunit 1. (764 aa) |
