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CPT1A CPT1A SLC16A2 SLC16A2 ETHE1 ETHE1 GSTO1 GSTO1 GSTZ1 GSTZ1 Ckmt1a Ckmt1a DMGDH DMGDH SERINC3 SERINC3 GDAP1 GDAP1 SLC5A5 SLC5A5 SLC16A10 SLC16A10 PCYOX1 PCYOX1 PLOD3 PLOD3 MTHFR MTHFR GGT6 GGT6 PTDSS1 PTDSS1 GCH1 GCH1 LIPC LIPC CKMT2 CKMT2 ABHD12 ABHD12 GGT7 GGT7 GSS GSS BHMT2 BHMT2 BBOX1 BBOX1 HOGA1 HOGA1 SHMT1 SHMT1 SLC22A4 SLC22A4 GART GART GSR GSR TMLHE TMLHE SERINC5 SERINC5 ALDH1L1 ALDH1L1 MTRR MTRR GPX3 GPX3 CPQ CPQ DUOX2 DUOX2 TXNRD3 TXNRD3 DUOX1 DUOX1 CPT1B CPT1B CLIC2 CLIC2 GGH GGH SLC1A2 SLC1A2 GSTM1 GSTM1 GATM GATM SERINC1 SERINC1 MBOAT1 MBOAT1 GGT5 GGT5 GCLC GCLC Dio1 Dio1 PTDSS2 PTDSS2 CTSB CTSB CTSV CTSV CGA CGA TG TG SLC27A1 SLC27A1 ACADL ACADL MTHFD1L MTHFD1L ALDH1L2 ALDH1L2 ABHD16A ABHD16A WDR37 WDR37 ACADM ACADM OPLAH OPLAH CROT CROT CPT2 CPT2 VNN1 VNN1 PLA2G3 PLA2G3 FOLR1 FOLR1 ATIC ATIC GSTO2 GSTO2 SHMT2 SHMT2 SLC1A1 SLC1A1 SLC7A11 SLC7A11 MTHFD1 MTHFD1 IDH1 IDH1 MMACHC MMACHC SOD1 SOD1 H0VQJ6_CAVPO H0VQJ6_CAVPO ABHD16B ABHD16B AHCY AHCY ABHD12B ABHD12B MTR MTR ALDH9A1 ALDH9A1 CPT1C CPT1C TYMS TYMS SLCO4A1 SLCO4A1 CTH CTH FPGS FPGS PLA2G10 PLA2G10 CKM CKM CRAT CRAT CRYM CRYM CCDC166 CCDC166 CTNS CTNS G6PD G6PD Asl Asl Iyd Iyd CLIC1 CLIC1 PLA2G15 PLA2G15 GDAP1L1 GDAP1L1 HPGDS HPGDS CHDH CHDH Kyat1 Kyat1 GSTP1 GSTP1 EEF1G EEF1G DPEP1 DPEP1 LPCAT4 LPCAT4 GSTT4 GSTT4 GSTK1 GSTK1 ASS1 ASS1 MGST2 MGST2 LOC100714389 LOC100714389 PCYOX1L PCYOX1L GSTA1_CAVPO GSTA1_CAVPO NFE2L1 NFE2L1 SOD2 SOD2 Dio2 Dio2 ARL6IP5 ARL6IP5 CHAC2 CHAC2 GGACT GGACT LOC100717041 LOC100717041 LOC100729580 LOC100729580 ALDH7A1 ALDH7A1 GAMT GAMT GSTM3 GSTM3 ENSCPOP00000024451 ENSCPOP00000024451 ENSCPOP00000024732 ENSCPOP00000024732 LOC100717315 LOC100717315 CLIC3 CLIC3 PCMT1 PCMT1 LPCAT3 LPCAT3 MTHFD2 MTHFD2 Mthfs Mthfs Ggt1 Ggt1 FOLH1 FOLH1 LOC100715394 LOC100715394 PTGES2 PTGES2 LOC100717598 LOC100717598 HAGH HAGH PEMT PEMT CLIC5 CLIC5 GNMT GNMT Vnn3 Vnn3 Dhfr Dhfr Gpx4 Gpx4 SARDH SARDH Gstm2 Gstm2 PLA2G2F PLA2G2F PLOD2 PLOD2 CTSK CTSK MED1 MED1 AASDHPPT AASDHPPT CHAC1 CHAC1 GSTA4 GSTA4 BHMT BHMT CKB CKB SERINC2 SERINC2 GLO1 GLO1 MGST1 MGST1 GCNT4 GCNT4 ICMT ICMT MBOAT2 MBOAT2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CPT1ACarnitine palmitoyltransferase 1A; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
SLC16A2Solute carrier family 16 member 2. (535 aa)
ETHE1ETHE1 persulfide dioxygenase. (227 aa)
GSTO1Glutathione S-transferase omega 1; Belongs to the GST superfamily. (239 aa)
GSTZ1Glutathione S-transferase zeta 1. (174 aa)
Ckmt1aUncharacterized protein; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
DMGDHDimethylglycine dehydrogenase. (852 aa)
SERINC3Serine incorporator 3. (465 aa)
GDAP1Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (356 aa)
SLC5A5Solute carrier family 5 member 5; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (617 aa)
SLC16A10Solute carrier family 16 member 10. (440 aa)
PCYOX1Prenylcysteine oxidase 1. (505 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (733 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (671 aa)
GGT6Gamma-glutamyltransferase 6. (500 aa)
PTDSS1Phosphatidylserine synthase 1. (398 aa)
GCH1GTP cyclohydrolase 1. (222 aa)
LIPCLipase C, hepatic type. (497 aa)
CKMT2Creatine kinase, mitochondrial 2; Belongs to the ATP:guanido phosphotransferase family. (419 aa)
ABHD12Abhydrolase domain containing 12. (397 aa)
GGT7Gamma-glutamyltransferase 7. (628 aa)
GSSGlutathione synthetase. (474 aa)
BHMT2Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa)
BBOX1Gamma-butyrobetaine hydroxylase 1. (387 aa)
HOGA14-hydroxy-2-oxoglutarate aldolase 1; Belongs to the DapA family. (321 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
SLC22A4Solute carrier family 22 member 4. (541 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (982 aa)
GSRGlutathione-disulfide reductase. (418 aa)
TMLHETrimethyllysine hydroxylase, epsilon. (302 aa)
SERINC5Serine incorporator 5. (462 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (748 aa)
GPX3Glutathione peroxidase; Belongs to the glutathione peroxidase family. (225 aa)
CPQCarboxypeptidase Q. (473 aa)
DUOX2Dual oxidase 2. (1517 aa)
TXNRD3Thioredoxin reductase 3. (612 aa)
DUOX1Dual oxidase 1. (1551 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (772 aa)
CLIC2Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (246 aa)
GGHFolate gamma-glutamyl hydrolase. (318 aa)
SLC1A2Amino acid transporter. (573 aa)
GSTM1Glutathione S-transferase B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (222 aa)
GATMGlycine amidinotransferase. (423 aa)
SERINC1Serine incorporator 1. (453 aa)
MBOAT1Membrane bound O-acyltransferase domain containing 1; Belongs to the membrane-bound acyltransferase family. (463 aa)
GGT5Gamma-glutamyltransferase 5. (570 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (639 aa)
Dio1Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (231 aa)
PTDSS2Phosphatidylserine synthase 2. (466 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (340 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (333 aa)
CGAGlycoprotein hormones alpha chain; Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. (120 aa)
TGThyroglobulin. (2742 aa)
SLC27A1Solute carrier family 27 member 1. (590 aa)
ACADLAcyl-CoA dehydrogenase long chain. (432 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (901 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)
ABHD16AAbhydrolase domain containing 16A. (558 aa)
WDR37WD repeat domain 37. (451 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (363 aa)
OPLAH5-oxoprolinase, ATP-hydrolysing. (1245 aa)
CROTCarnitine O-octanoyltransferase; Belongs to the carnitine/choline acetyltransferase family. (580 aa)
CPT2Carnitine palmitoyltransferase 2; Belongs to the carnitine/choline acetyltransferase family. (658 aa)
VNN1Vanin 1. (513 aa)
PLA2G3Phospholipase A2 group III. (645 aa)
FOLR1Folate receptor alpha. (160 aa)
ATIC5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (561 aa)
GSTO2Glutathione S-transferase omega 2; Belongs to the GST superfamily. (244 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
SLC1A1Amino acid transporter. (525 aa)
SLC7A11Solute carrier family 7 member 11. (507 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (928 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
MMACHCMetabolism of cobalamin associated C. (275 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
H0VQJ6_CAVPONitroreductase domain-containing protein. (193 aa)
ABHD16BAbhydrolase domain containing 16B. (466 aa)
AHCYAdenosylhomocysteinase; Belongs to the adenosylhomocysteinase family. (432 aa)
ABHD12BAbhydrolase domain containing 12B. (328 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1265 aa)
ALDH9A1Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family. (518 aa)
CPT1CCarnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (807 aa)
TYMSThymidylate synthetase. (314 aa)
SLCO4A1Solute carrier organic anion transporter family member. (711 aa)
CTHCystathionine gamma-lyase. (399 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (582 aa)
PLA2G10Phospholipase A(2). (152 aa)
CKMCreatine kinase, M-type; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
CRATCarnitine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (626 aa)
CRYMCrystallin mu. (314 aa)
CCDC166Coiled-coil domain containing 166. (439 aa)
CTNSCystinosin, lysosomal cystine transporter. (319 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
AslUncharacterized protein. (465 aa)
IydNitroreductase domain-containing protein. (285 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
GDAP1L1Ganglioside induced differentiation associated protein 1 like 1. (367 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
CHDHCholine dehydrogenase. (594 aa)
Kyat1Aminotran_1_2 domain-containing protein. (424 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
EEF1GEukaryotic translation elongation factor 1 gamma. (437 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (410 aa)
LPCAT4Lysophosphatidylcholine acyltransferase 4. (523 aa)
GSTT4Glutathione S-transferase theta 4; Belongs to the GST superfamily. (241 aa)
GSTK1Glutathione S-transferase kappa. (226 aa)
ASS1Argininosuccinate synthase 1. (415 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
LOC100714389N-acetyltransferase domain-containing protein. (229 aa)
PCYOX1LPrenylcysteine oxidase 1 like. (494 aa)
GSTA1_CAVPOGlutathione S-transferase A; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (743 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
Dio2Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (256 aa)
ARL6IP5PRA1 family protein. (188 aa)
CHAC2Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (178 aa)
GGACTGamma-glutamylamine cyclotransferase. (150 aa)
LOC100717041Uncharacterized protein; Belongs to the GST superfamily. (244 aa)
LOC100729580Sulfotransferase; Belongs to the sulfotransferase 1 family. (294 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (539 aa)
GAMTGuanidinoacetate N-methyltransferase; Converts guanidinoacetate to creatine, using S- adenosylmethionine as the methyl donor. Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family. (236 aa)
GSTM3Glutathione S-transferase mu 3; Belongs to the GST superfamily. (225 aa)
ENSCPOP00000024451Uncharacterized protein. (153 aa)
ENSCPOP00000024732Uncharacterized protein. (121 aa)
LOC100717315Uncharacterized protein. (240 aa)
CLIC3Chloride intracellular channel 3. (237 aa)
PCMT1Protein-L-isoaspartate O-methyltransferase. (285 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (487 aa)
MTHFD2Uncharacterized protein. (350 aa)
Mthfs5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (173 aa)
Ggt1Uncharacterized protein. (569 aa)
FOLH1Folate hydrolase 1. (751 aa)
LOC100715394Uncharacterized protein; Belongs to the GST superfamily. (222 aa)
PTGES2Prostaglandin E synthase 2; Belongs to the GST superfamily. (370 aa)
LOC100717598Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
HAGHHydroxyacylglutathione hydrolase. (260 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (215 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (252 aa)
GNMTGlycine N-methyltransferase. (295 aa)
Vnn3Uncharacterized protein. (377 aa)
DhfrDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
Gpx4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (196 aa)
SARDHSarcosine dehydrogenase. (919 aa)
Gstm2Glutathione S-transferase. (218 aa)
PLA2G2FPhospholipase A(2). (214 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (691 aa)
CTSKCathepsin K; Belongs to the peptidase C1 family. (329 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1584 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
CHAC1Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (222 aa)
GSTA4Glutathione S-transferase alpha 4. (252 aa)
BHMTBetaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (396 aa)
CKBCreatine kinase B; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
SERINC2Serine incorporator 2. (456 aa)
GLO1Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (185 aa)
MGST1Microsomal glutathione S-transferase 1. (156 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (455 aa)
ICMTProtein-S-isoprenylcysteine O-methyltransferase. (284 aa)
MBOAT2Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (537 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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