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LOC100723961 LOC100723961 ACER3 ACER3 ST3GAL2 ST3GAL2 SPTSSA SPTSSA B4GALT3 B4GALT3 B3GALT1 B3GALT1 SMPD4 SMPD4 ST3GAL1 ST3GAL1 P2RX1 P2RX1 ORMDL1 ORMDL1 ACER2 ACER2 A3GALT2 A3GALT2 SGMS2 SGMS2 ENPP2 ENPP2 PEMT PEMT HTRA2 HTRA2 ELOVL6 ELOVL6 CPTP CPTP ENSCPOP00000026943 ENSCPOP00000026943 ST8SIA4 ST8SIA4 SAMD8 SAMD8 SPHK2 SPHK2 KDSR KDSR St6galnac6 St6galnac6 TECR TECR SPTSSB SPTSSB ORMDL2 ORMDL2 GM2A GM2A ENSCPOP00000024878 ENSCPOP00000024878 Gdf1 Gdf1 GBGT1 GBGT1 ST3GAL3 ST3GAL3 B4GALT6 B4GALT6 ST8SIA2 ST8SIA2 CYP4F22 CYP4F22 ORMDL3 ORMDL3 ST6GALNAC3 ST6GALNAC3 ST8SIA5 ST8SIA5 ENSCPOP00000022694 ENSCPOP00000022694 TM9SF2 TM9SF2 B3GALT2 B3GALT2 SGPL1 SGPL1 SGPP1 SGPP1 ZPBP2 ZPBP2 Plpp3 Plpp3 CERS6 CERS6 NAGA NAGA DEGS2 DEGS2 CERK CERK PLA2G15 PLA2G15 A4GALT A4GALT PLPP2 PLPP2 CERS4 CERS4 ST6GALNAC4 ST6GALNAC4 B3GALT4 B3GALT4 ST8SIA3 ST8SIA3 FADS3 FADS3 GBA3 GBA3 ACER1 ACER1 AGK AGK CREM CREM FA2H FA2H SPTLC1 SPTLC1 SGMS1 SGMS1 ASAH2 ASAH2 ELOVL3 ELOVL3 ST8SIA6 ST8SIA6 NEU1 NEU1 ABCA2 ABCA2 SPNS2 SPNS2 HACD4 HACD4 HACD3 HACD3 B4GALT5 B4GALT5 NEU4 NEU4 ASAH1 ASAH1 SERINC1 SERINC1 ELOVL2 ELOVL2 NAAA NAAA DEGS1 DEGS1 SMPDL3B SMPDL3B ITGB8 ITGB8 UGCG UGCG HACD1 HACD1 NEU2 NEU2 PNPLA1 PNPLA1 B4GALT4 B4GALT4 FUT9 FUT9 B4GALNT1 B4GALNT1 GBA GBA SMPD2 SMPD2 ARV1 ARV1 PSAP PSAP SERINC3 SERINC3 SGPP2 SGPP2 SMPD1 SMPD1 FUT4 FUT4 GBA2 GBA2 CERS5 CERS5 GLA GLA SPTLC2 SPTLC2 CERT1 CERT1 CERS2 CERS2 H0VER4_CAVPO H0VER4_CAVPO GALC GALC Plpp1 Plpp1 TMEM130 TMEM130 Hexa Hexa KIT KIT ST6GALNAC5 ST6GALNAC5 UGT8 UGT8 SPHK1 SPHK1 TH TH CLN6 CLN6 NEU3 NEU3 HEXB HEXB ELOVL1 ELOVL1 SERINC5 SERINC5 VAPA VAPA ALOXE3 ALOXE3 ALOX12B ALOX12B GAL3ST1 GAL3ST1 ABCA12 ABCA12 OSBP OSBP MAP7 MAP7 ELOVL5 ELOVL5 TLCD3B TLCD3B CEL CEL ELOVL4 ELOVL4 FUT7 FUT7 Cln8 Cln8 BAX BAX LOC100724236 LOC100724236 HACD2 HACD2 SMPD3 SMPD3 SFTPB SFTPB SERINC2 SERINC2 ELOVL7 ELOVL7
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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LOC100723961Glyco_tran_10_N domain-containing protein. (380 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
B4GALT3Beta-1,4-galactosyltransferase 3. (396 aa)
B3GALT1Hexosyltransferase. (326 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (823 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
A3GALT2Alpha 1,3-galactosyltransferase 2. (337 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase 2. (857 aa)
PEMTPhosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (215 aa)
HTRA2HtrA serine peptidase 2. (455 aa)
ELOVL6Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
ENSCPOP00000026943TLC domain-containing protein. (287 aa)
ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (359 aa)
SAMD8Sterile alpha motif domain containing 8. (415 aa)
SPHK2Sphingosine kinase 2. (655 aa)
KDSR3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa)
St6galnac6Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (332 aa)
TECRTrans-2,3-enoyl-CoA reductase. (346 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
GM2AGM2 ganglioside activator. (166 aa)
ENSCPOP00000024878Uncharacterized protein. (110 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
GBGT1Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group). (347 aa)
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (335 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (375 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (547 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ST6GALNAC3ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (305 aa)
ST8SIA5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (412 aa)
ENSCPOP00000022694Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (305 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (663 aa)
B3GALT2Hexosyltransferase. (422 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (407 aa)
ZPBP2Zona pellucida binding protein 2. (326 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
CERS6Ceramide synthase 6. (392 aa)
NAGAAlpha-galactosidase. (413 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (315 aa)
CERKCeramide kinase. (483 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
A4GALTAlpha 1,4-galactosyltransferase (P blood group). (353 aa)
PLPP2Phospholipid phosphatase 2. (260 aa)
CERS4Ceramide synthase 4. (391 aa)
ST6GALNAC4ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (302 aa)
B3GALT4Hexosyltransferase. (416 aa)
ST8SIA3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (323 aa)
FADS3Fatty acid desaturase 3. (441 aa)
GBA3Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (Probable). Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear (By similarity). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear (By similarity). It can also hydrolyze a broad variety of dietary glycosides including phyt [...] (399 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa)
AGKAcylglycerol kinase. (421 aa)
CREMcAMP responsive element modulator. (314 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
ASAH2Neutral ceramidase. (752 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (271 aa)
ST8SIA6ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (398 aa)
NEU1Neuraminidase 1. (404 aa)
ABCA2ATP binding cassette subfamily A member 2. (2427 aa)
SPNS2Sphingolipid transporter 2. (549 aa)
HACD4Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (231 aa)
HACD3Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (349 aa)
NEU4Neuraminidase 4. (457 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
SERINC1Serine incorporator 1. (453 aa)
ELOVL2Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (290 aa)
NAAAN-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. (347 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
SMPDL3BAcid sphingomyelinase-like phosphodiesterase. (457 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (393 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (249 aa)
NEU2Neuraminidase 2. (381 aa)
PNPLA1Patatin like phospholipase domain containing 1. (554 aa)
B4GALT4Beta-1,4-galactosyltransferase 4. (347 aa)
FUT9Fucosyltransferase 9. (359 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa)
GBAGlucosylceramidase. (516 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (430 aa)
ARV1ARV1 homolog, fatty acid homeostasis modulator. (259 aa)
PSAPSaposin-C; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. (536 aa)
SERINC3Serine incorporator 3. (465 aa)
SGPP2Sphingosine-1-phosphate phosphatase 2. (354 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
FUT4Fucosyltransferase 4. (519 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa)
CERS5Ceramide synthase 5. (428 aa)
GLAAlpha-galactosidase. (428 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
CERT1Ceramide transporter 1. (564 aa)
CERS2Ceramide synthase 2. (380 aa)
H0VER4_CAVPODAGKc domain-containing protein. (277 aa)
GALCGalactosylceramidase. (685 aa)
Plpp1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these b [...] (284 aa)
TMEM130Transmembrane protein 130. (345 aa)
HexaBeta-hexosaminidase. (527 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
ST6GALNAC5ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (329 aa)
UGT8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa)
SPHK1Sphingosine kinase 1. (386 aa)
THTyrosine hydroxylase. (498 aa)
CLN6CLN6 transmembrane ER protein. (310 aa)
NEU3Neuraminidase 3. (415 aa)
HEXBHexosaminidase subunit beta. (442 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (313 aa)
SERINC5Serine incorporator 5. (462 aa)
VAPAVAMP associated protein A. (222 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (700 aa)
GAL3ST1Galactose-3-O-sulfotransferase 1. (423 aa)
ABCA12ATP binding cassette subfamily A member 12. (2597 aa)
OSBPOxysterol binding protein. (767 aa)
MAP7Microtubule associated protein 7. (661 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (294 aa)
TLCD3BTLC domain containing 3B. (275 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (594 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (312 aa)
FUT7Fucosyltransferase 7. (342 aa)
Cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
LOC100724236Glyco_tran_10_N domain-containing protein. (380 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (202 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
SFTPBUncharacterized protein. (379 aa)
SERINC2Serine incorporator 2. (456 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (279 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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