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| | LOC100723961 | Glyco_tran_10_N domain-containing protein. (380 aa) |
| | ACER3 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa) |
| | ST3GAL2 | ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa) |
| | SPTSSA | Serine palmitoyltransferase small subunit A. (71 aa) |
| | B4GALT3 | Beta-1,4-galactosyltransferase 3. (396 aa) |
| | B3GALT1 | Hexosyltransferase. (326 aa) |
| | SMPD4 | Sphingomyelin phosphodiesterase 4. (823 aa) |
| | ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa) |
| | P2RX1 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa) |
| | ORMDL1 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa) |
| | A3GALT2 | Alpha 1,3-galactosyltransferase 2. (337 aa) |
| | SGMS2 | Sphingomyelin synthase 2. (365 aa) |
| | ENPP2 | Ectonucleotide pyrophosphatase/phosphodiesterase 2. (857 aa) |
| | PEMT | Phosphatidylethanolamine N-methyltransferase; Catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC); Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family. (215 aa) |
| | HTRA2 | HtrA serine peptidase 2. (455 aa) |
| | ELOVL6 | Elongation of very long chain fatty acids protein 6; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degre [...] (265 aa) |
| | CPTP | Ceramide-1-phosphate transfer protein. (214 aa) |
| | ENSCPOP00000026943 | TLC domain-containing protein. (287 aa) |
| | ST8SIA4 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (359 aa) |
| | SAMD8 | Sterile alpha motif domain containing 8. (415 aa) |
| | SPHK2 | Sphingosine kinase 2. (655 aa) |
| | KDSR | 3-ketodihydrosphingosine reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (332 aa) |
| | St6galnac6 | Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (332 aa) |
| | TECR | Trans-2,3-enoyl-CoA reductase. (346 aa) |
| | SPTSSB | Serine palmitoyltransferase small subunit B. (76 aa) |
| | ORMDL2 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | GM2A | GM2 ganglioside activator. (166 aa) |
| | ENSCPOP00000024878 | Uncharacterized protein. (110 aa) |
| | Gdf1 | TGF_BETA_2 domain-containing protein. (367 aa) |
| | GBGT1 | Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group). (347 aa) |
| | ST3GAL3 | ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (335 aa) |
| | B4GALT6 | Beta-1,4-galactosyltransferase 6. (382 aa) |
| | ST8SIA2 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (375 aa) |
| | CYP4F22 | Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (547 aa) |
| | ORMDL3 | ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa) |
| | ST6GALNAC3 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (305 aa) |
| | ST8SIA5 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (412 aa) |
| | ENSCPOP00000022694 | Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (305 aa) |
| | TM9SF2 | Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (663 aa) |
| | B3GALT2 | Hexosyltransferase. (422 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (568 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (407 aa) |
| | ZPBP2 | Zona pellucida binding protein 2. (326 aa) |
| | Plpp3 | acidPPc domain-containing protein. (312 aa) |
| | CERS6 | Ceramide synthase 6. (392 aa) |
| | NAGA | Alpha-galactosidase. (413 aa) |
| | DEGS2 | Delta 4-desaturase, sphingolipid 2. (315 aa) |
| | CERK | Ceramide kinase. (483 aa) |
| | PLA2G15 | Phospholipase A2 group XV. (412 aa) |
| | A4GALT | Alpha 1,4-galactosyltransferase (P blood group). (353 aa) |
| | PLPP2 | Phospholipid phosphatase 2. (260 aa) |
| | CERS4 | Ceramide synthase 4. (391 aa) |
| | ST6GALNAC4 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (302 aa) |
| | B3GALT4 | Hexosyltransferase. (416 aa) |
| | ST8SIA3 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (323 aa) |
| | FADS3 | Fatty acid desaturase 3. (441 aa) |
| | GBA3 | Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (Probable). Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear (By similarity). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear (By similarity). It can also hydrolyze a broad variety of dietary glycosides including phyt [...] (399 aa) |
| | ACER1 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa) |
| | AGK | Acylglycerol kinase. (421 aa) |
| | CREM | cAMP responsive element modulator. (314 aa) |
| | FA2H | Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (461 aa) |
| | SGMS1 | Sphingomyelin synthase 1. (413 aa) |
| | ASAH2 | Neutral ceramidase. (752 aa) |
| | ELOVL3 | Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (271 aa) |
| | ST8SIA6 | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (398 aa) |
| | NEU1 | Neuraminidase 1. (404 aa) |
| | ABCA2 | ATP binding cassette subfamily A member 2. (2427 aa) |
| | SPNS2 | Sphingolipid transporter 2. (549 aa) |
| | HACD4 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (231 aa) |
| | HACD3 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa) |
| | B4GALT5 | Beta-1,4-galactosyltransferase 5. (349 aa) |
| | NEU4 | Neuraminidase 4. (457 aa) |
| | ASAH1 | N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa) |
| | SERINC1 | Serine incorporator 1. (453 aa) |
| | ELOVL2 | Elongation of very long chain fatty acids protein 2; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production [...] (290 aa) |
| | NAAA | N-acylethanolamine-hydrolyzing acid amidase subunit alpha; Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N- myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine. (347 aa) |
| | DEGS1 | Delta 4-desaturase, sphingolipid 1. (323 aa) |
| | SMPDL3B | Acid sphingomyelinase-like phosphodiesterase. (457 aa) |
| | ITGB8 | Integrin beta; Belongs to the integrin beta chain family. (768 aa) |
| | UGCG | UDP-glucose ceramide glucosyltransferase. (393 aa) |
| | HACD1 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (249 aa) |
| | NEU2 | Neuraminidase 2. (381 aa) |
| | PNPLA1 | Patatin like phospholipase domain containing 1. (554 aa) |
| | B4GALT4 | Beta-1,4-galactosyltransferase 4. (347 aa) |
| | FUT9 | Fucosyltransferase 9. (359 aa) |
| | B4GALNT1 | Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa) |
| | GBA | Glucosylceramidase. (516 aa) |
| | SMPD2 | Sphingomyelin phosphodiesterase 2. (430 aa) |
| | ARV1 | ARV1 homolog, fatty acid homeostasis modulator. (259 aa) |
| | PSAP | Saposin-C; Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin- C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. (536 aa) |
| | SERINC3 | Serine incorporator 3. (465 aa) |
| | SGPP2 | Sphingosine-1-phosphate phosphatase 2. (354 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | FUT4 | Fucosyltransferase 4. (519 aa) |
| | GBA2 | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa) |
| | CERS5 | Ceramide synthase 5. (428 aa) |
| | GLA | Alpha-galactosidase. (428 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (562 aa) |
| | CERT1 | Ceramide transporter 1. (564 aa) |
| | CERS2 | Ceramide synthase 2. (380 aa) |
| | H0VER4_CAVPO | DAGKc domain-containing protein. (277 aa) |
| | GALC | Galactosylceramidase. (685 aa) |
| | Plpp1 | Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these b [...] (284 aa) |
| | TMEM130 | Transmembrane protein 130. (345 aa) |
| | Hexa | Beta-hexosaminidase. (527 aa) |
| | KIT | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa) |
| | ST6GALNAC5 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (329 aa) |
| | UGT8 | UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa) |
| | SPHK1 | Sphingosine kinase 1. (386 aa) |
| | TH | Tyrosine hydroxylase. (498 aa) |
| | CLN6 | CLN6 transmembrane ER protein. (310 aa) |
| | NEU3 | Neuraminidase 3. (415 aa) |
| | HEXB | Hexosaminidase subunit beta. (442 aa) |
| | ELOVL1 | Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (313 aa) |
| | SERINC5 | Serine incorporator 5. (462 aa) |
| | VAPA | VAMP associated protein A. (222 aa) |
| | ALOXE3 | Arachidonate lipoxygenase 3. (711 aa) |
| | ALOX12B | Arachidonate 12-lipoxygenase, 12R type. (700 aa) |
| | GAL3ST1 | Galactose-3-O-sulfotransferase 1. (423 aa) |
| | ABCA12 | ATP binding cassette subfamily A member 12. (2597 aa) |
| | OSBP | Oxysterol binding protein. (767 aa) |
| | MAP7 | Microtubule associated protein 7. (661 aa) |
| | ELOVL5 | Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (294 aa) |
| | TLCD3B | TLC domain containing 3B. (275 aa) |
| | CEL | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (594 aa) |
| | ELOVL4 | Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (312 aa) |
| | FUT7 | Fucosyltransferase 7. (342 aa) |
| | Cln8 | CLN8 transmembrane ER and ERGIC protein. (288 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | LOC100724236 | Glyco_tran_10_N domain-containing protein. (380 aa) |
| | HACD2 | Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (202 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (656 aa) |
| | SFTPB | Uncharacterized protein. (379 aa) |
| | SERINC2 | Serine incorporator 2. (456 aa) |
| | ELOVL7 | Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (279 aa) |
