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ABCA2 ABCA2 NEU1 NEU1 ST8SIA6 ST8SIA6 ASAH2 ASAH2 SGMS1 SGMS1 SPTLC1 SPTLC1 FA2H FA2H AGK AGK ACER1 ACER1 GBA3 GBA3 ST8SIA3 ST8SIA3 B3GALT4 B3GALT4 ST6GALNAC4 ST6GALNAC4 CERS4 CERS4 PLPP2 PLPP2 PLA2G15 PLA2G15 CERK CERK DEGS2 DEGS2 ELOVL1 ELOVL1 HEXB HEXB NEU3 NEU3 ST8SIA4 ST8SIA4 CLN6 CLN6 NEU4 NEU4 ASAH1 ASAH1 DEGS1 DEGS1 ITGB8 ITGB8 UGCG UGCG NEU2 NEU2 GALC GALC Plpp1 Plpp1 TMEM130 TMEM130 Hexa Hexa ST6GALNAC5 ST6GALNAC5 UGT8 UGT8 GAL3ST1 GAL3ST1 ALOX12B ALOX12B ALOXE3 ALOXE3 FUT7 FUT7 Cln8 Cln8 LOC100724236 LOC100724236 SMPD3 SMPD3 LOC100723961 LOC100723961 ACER3 ACER3 ST3GAL2 ST3GAL2 SPTSSA SPTSSA B4GALT3 B4GALT3 B3GALT1 B3GALT1 SMPD4 SMPD4 ST3GAL1 ST3GAL1 P2RX1 P2RX1 ORMDL1 ORMDL1 ACER2 ACER2 SGMS2 SGMS2 HTRA2 HTRA2 ENSCPOP00000026943 ENSCPOP00000026943 GBA2 GBA2 CERS5 CERS5 GLA GLA SPTLC2 SPTLC2 CERT1 CERT1 CERS2 CERS2 SMPD1 SMPD1 CEL CEL SMPD2 SMPD2 GBA GBA B4GALNT1 B4GALNT1 B4GALT4 B4GALT4 PNPLA1 PNPLA1 TLCD3B TLCD3B ABCA12 ABCA12 NAGA NAGA CERS6 CERS6 Plpp3 Plpp3 SGPL1 SGPL1 B3GALT2 B3GALT2 TM9SF2 TM9SF2 ENSCPOP00000022694 ENSCPOP00000022694 ST6GALNAC3 ST6GALNAC3 ORMDL3 ORMDL3 CYP4F22 CYP4F22 ST8SIA2 ST8SIA2 B4GALT6 B4GALT6 ST3GAL3 ST3GAL3 Gdf1 Gdf1 ENSCPOP00000024878 ENSCPOP00000024878 GM2A GM2A ORMDL2 ORMDL2 SPTSSB SPTSSB St6galnac6 St6galnac6 SAMD8 SAMD8 B4GALT5 B4GALT5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCA2ATP binding cassette subfamily A member 2. (2427 aa)
NEU1Neuraminidase 1. (404 aa)
ST8SIA6ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6; Belongs to the glycosyltransferase 29 family. (398 aa)
ASAH2Neutral ceramidase. (752 aa)
SGMS1Sphingomyelin synthase 1. (413 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
AGKAcylglycerol kinase. (421 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (268 aa)
GBA3Cytosolic beta-glucosidase; Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides (Probable). Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear (By similarity). Also able to hydrolyze galactosylceramide/GalCer, glucosylsphingosine/GlcSph and galactosylsphingosine/GalSph. However, the in vivo relevance of these activities is unclear (By similarity). It can also hydrolyze a broad variety of dietary glycosides including phyt [...] (399 aa)
ST8SIA3ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (323 aa)
B3GALT4Hexosyltransferase. (416 aa)
ST6GALNAC4ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (302 aa)
CERS4Ceramide synthase 4. (391 aa)
PLPP2Phospholipid phosphatase 2. (260 aa)
PLA2G15Phospholipase A2 group XV. (412 aa)
CERKCeramide kinase. (483 aa)
DEGS2Delta 4-desaturase, sphingolipid 2. (315 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (313 aa)
HEXBHexosaminidase subunit beta. (442 aa)
NEU3Neuraminidase 3. (415 aa)
ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4; Belongs to the glycosyltransferase 29 family. (359 aa)
CLN6CLN6 transmembrane ER protein. (310 aa)
NEU4Neuraminidase 4. (457 aa)
ASAH1N-acylsphingosine amidohydrolase 1; Belongs to the acid ceramidase family. (395 aa)
DEGS1Delta 4-desaturase, sphingolipid 1. (323 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (768 aa)
UGCGUDP-glucose ceramide glucosyltransferase. (393 aa)
NEU2Neuraminidase 2. (381 aa)
GALCGalactosylceramidase. (685 aa)
Plpp1Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these b [...] (284 aa)
TMEM130Transmembrane protein 130. (345 aa)
HexaBeta-hexosaminidase. (527 aa)
ST6GALNAC5ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; Belongs to the glycosyltransferase 29 family. (329 aa)
UGT8UDP glycosyltransferase 8; Belongs to the UDP-glycosyltransferase family. (541 aa)
GAL3ST1Galactose-3-O-sulfotransferase 1. (423 aa)
ALOX12BArachidonate 12-lipoxygenase, 12R type. (700 aa)
ALOXE3Arachidonate lipoxygenase 3. (711 aa)
FUT7Fucosyltransferase 7. (342 aa)
Cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
LOC100724236Glyco_tran_10_N domain-containing protein. (380 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
LOC100723961Glyco_tran_10_N domain-containing protein. (380 aa)
ACER3Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (267 aa)
ST3GAL2ST3 beta-galactoside alpha-2,3-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (350 aa)
SPTSSASerine palmitoyltransferase small subunit A. (71 aa)
B4GALT3Beta-1,4-galactosyltransferase 3. (396 aa)
B3GALT1Hexosyltransferase. (326 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (823 aa)
ST3GAL1ST3 beta-galactoside alpha-2,3-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (339 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
ORMDL1ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
SGMS2Sphingomyelin synthase 2. (365 aa)
HTRA2HtrA serine peptidase 2. (455 aa)
ENSCPOP00000026943TLC domain-containing protein. (287 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (908 aa)
CERS5Ceramide synthase 5. (428 aa)
GLAAlpha-galactosidase. (428 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
CERT1Ceramide transporter 1. (564 aa)
CERS2Ceramide synthase 2. (380 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
CELCarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (594 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (430 aa)
GBAGlucosylceramidase. (516 aa)
B4GALNT1Beta-1,4 N-acetylgalactosaminyltransferase. (533 aa)
B4GALT4Beta-1,4-galactosyltransferase 4. (347 aa)
PNPLA1Patatin like phospholipase domain containing 1. (554 aa)
TLCD3BTLC domain containing 3B. (275 aa)
ABCA12ATP binding cassette subfamily A member 12. (2597 aa)
NAGAAlpha-galactosidase. (413 aa)
CERS6Ceramide synthase 6. (392 aa)
Plpp3acidPPc domain-containing protein. (312 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
B3GALT2Hexosyltransferase. (422 aa)
TM9SF2Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (663 aa)
ENSCPOP00000022694Uncharacterized protein; Belongs to the glycosyl hydrolase 1 family. (305 aa)
ST6GALNAC3ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (305 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (547 aa)
ST8SIA2ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2; Belongs to the glycosyltransferase 29 family. (375 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3; Belongs to the glycosyltransferase 29 family. (335 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
ENSCPOP00000024878Uncharacterized protein. (110 aa)
GM2AGM2 ganglioside activator. (166 aa)
ORMDL2ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
SPTSSBSerine palmitoyltransferase small subunit B. (76 aa)
St6galnac6Uncharacterized protein; Belongs to the glycosyltransferase 29 family. (332 aa)
SAMD8Sterile alpha motif domain containing 8. (415 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (349 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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