STRINGSTRING
CYP2S1 CYP2S1 TBXAS1 TBXAS1 AKR1B1 AKR1B1 Hpgd Hpgd PTGS2 PTGS2 LOC100724620 LOC100724620 LOC100723652 LOC100723652 PLA2G4F PLA2G4F LOC100728682 LOC100728682 PTGS1 PTGS1 GSTM1 GSTM1 DAGLB DAGLB ATP6V1B1 ATP6V1B1 EDN2 EDN2 SPHK1 SPHK1 PLAA PLAA ACOX1 ACOX1 PLA2G10 PLA2G10 H0VZA0_CAVPO H0VZA0_CAVPO ZADH2 ZADH2 HPGDS HPGDS GSTP1 GSTP1 PTGR1 PTGR1 PRXL2B PRXL2B LOC100714126 LOC100714126 Pdpn Pdpn PLA2G4A PLA2G4A LOC100724941 LOC100724941 PNPLA8 PNPLA8 PTGES PTGES CD74 CD74 LOC100723931 LOC100723931 Ptgds Ptgds PTGES2 PTGES2 PTGIS PTGIS EDN1 EDN1 TNFRSF1A TNFRSF1A PTGES3 PTGES3 Gstm2 Gstm2 LOC100734360 LOC100734360 Ptgr2 Ptgr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP2S1Cytochrome P450 family 2 subfamily S member 1. (503 aa)
TBXAS1Thromboxane A synthase 1; Belongs to the cytochrome P450 family. (533 aa)
AKR1B1Aldo-keto reductase family 1 member B. (316 aa)
Hpgd15-hydroxyprostaglandin dehydrogenase [NAD(+)]; Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. (260 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
LOC100724620Aldo-keto reductase family 1 member C3. (323 aa)
LOC100723652Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (507 aa)
PLA2G4FPhospholipase A2. (842 aa)
LOC100728682Uncharacterized protein. (301 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (553 aa)
GSTM1Glutathione S-transferase B; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (222 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
EDN2Endothelin 2. (179 aa)
SPHK1Sphingosine kinase 1. (386 aa)
PLAAPhospholipase A2 activating protein. (782 aa)
ACOX1Peroxisomal acyl-CoA oxidase 1, A chain; Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl- CoAs. (660 aa)
PLA2G10Phospholipase A(2). (152 aa)
H0VZA0_CAVPOUncharacterized protein. (229 aa)
ZADH2Zinc binding alcohol dehydrogenase domain containing 2. (307 aa)
HPGDSHematopoietic prostaglandin D synthase. (199 aa)
GSTP1Glutathione S-transferase pi 1. (210 aa)
PTGR1Prostaglandin reductase 1; Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-oxo-PGE1, 15-oxo-PGE2 and 15-oxo-PGE2-alpha. Catalyzes the conversion of leukotriene B4 into its biologically less active metabolite, 12-oxo-leukotriene B4. This is an initial and key step of metabolic inactivation of leukotriene B4. (287 aa)
PRXL2BPeroxiredoxin like 2B. (201 aa)
LOC100714126Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (558 aa)
PdpnUncharacterized protein. (158 aa)
PLA2G4APhospholipase A2. (749 aa)
LOC100724941COesterase domain-containing protein; Belongs to the type-B carboxylesterase/lipase family. (792 aa)
PNPLA8Patatin like phospholipase domain containing 8. (781 aa)
PTGESProstaglandin E synthase. (153 aa)
CD74CD74 molecule. (280 aa)
LOC100723931Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (462 aa)
PtgdsLipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
PTGES2Prostaglandin E synthase 2; Belongs to the GST superfamily. (370 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (475 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
PTGES3Prostaglandin E synthase 3. (160 aa)
Gstm2Glutathione S-transferase. (218 aa)
LOC100734360Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
Ptgr2Uncharacterized protein. (350 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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