37 items (Cavia porcellus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	SREBF1	Sterol regulatory element binding transcription factor 1. (1155 aa)
	H0VU94_CAVPO	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (520 aa)
	DHCR24	24-dehydrocholesterol reductase. (516 aa)
	FDPS	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (248 aa)
	CYP51A1	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
	APOA5	Apolipoprotein A5. (429 aa)
	MSMO1	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family. (293 aa)
	PMVK	Phosphomevalonate kinase. (192 aa)
	EBP	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family. (229 aa)
	LSS	Terpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (733 aa)
	CFTR	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1448 aa)
	ENSCPOP00000024925	COesterase domain-containing protein. (295 aa)
	IDI1	Isopentenyl-diphosphate delta isomerase 1. (227 aa)
	LOC100717473	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (561 aa)
	Ces1d	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	HMGCS1	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (520 aa)
	Lbr	Tudor domain-containing protein. (133 aa)
	MVK	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
	MVD	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (402 aa)
	LOC100730472	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (559 aa)
	HSD17B7	Hydroxysteroid 17-beta dehydrogenase 7. (334 aa)
	APOA1	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family. (264 aa)
	TM7SF2	Transmembrane 7 superfamily member 2. (418 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (552 aa)
	Insig2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
	FDFT1	Farnesyl-diphosphate farnesyltransferase 1. (417 aa)
	HMGCS2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	HMGCR	3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
	NSDHL	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (361 aa)
	LOC100721835	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (565 aa)
	DHCR7	7-dehydrocholesterol reductase. (475 aa)
	SC5D	Sterol-C5-desaturase; Belongs to the sterol desaturase family. (298 aa)
	ENSCPOP00000026343	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (214 aa)
	CYB5R3	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (301 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APOA5	ENSCPOP00000032306	ENSCPOP00000013010	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	Apolipoprotein A5.	0.827
APOA1	HMGCR	ENSCPOP00000032306	ENSCPOP00000003857	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.440
APOA5	APOA1	ENSCPOP00000013010	ENSCPOP00000032306	Apolipoprotein A5.	Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility; Belongs to the apolipoprotein A1/A4/E family.	0.827
CFTR	PRKAA1	ENSCPOP00000011489	ENSCPOP00000004902	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Non-specific serine/threonine protein kinase.	0.852
CFTR	PRKAA2	ENSCPOP00000011489	ENSCPOP00000008947	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...]	Non-specific serine/threonine protein kinase.	0.840
CYB5R3	DHCR24	ENSCPOP00000015927	ENSCPOP00000014098	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	24-dehydrocholesterol reductase.	0.435
CYB5R3	NSDHL	ENSCPOP00000015927	ENSCPOP00000002615	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	NAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family.	0.467
CYP51A1	DHCR24	ENSCPOP00000013149	ENSCPOP00000014098	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	24-dehydrocholesterol reductase.	0.989
CYP51A1	DHCR7	ENSCPOP00000013149	ENSCPOP00000028710	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	7-dehydrocholesterol reductase.	0.988
CYP51A1	EBP	ENSCPOP00000013149	ENSCPOP00000012749	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase; Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers; Belongs to the EBP family.	0.533
CYP51A1	ENSCPOP00000026343	ENSCPOP00000013149	ENSCPOP00000026343	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.489
CYP51A1	FDFT1	ENSCPOP00000013149	ENSCPOP00000006939	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Farnesyl-diphosphate farnesyltransferase 1.	0.998
CYP51A1	FDPS	ENSCPOP00000013149	ENSCPOP00000013849	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Farnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family.	0.797
CYP51A1	HMGCR	ENSCPOP00000013149	ENSCPOP00000003857	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.942
CYP51A1	HMGCS1	ENSCPOP00000013149	ENSCPOP00000023141	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.965
CYP51A1	HMGCS2	ENSCPOP00000013149	ENSCPOP00000005713	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.930
CYP51A1	HSD17B7	ENSCPOP00000013149	ENSCPOP00000032694	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Hydroxysteroid 17-beta dehydrogenase 7.	0.998
CYP51A1	IDI1	ENSCPOP00000013149	ENSCPOP00000023821	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Isopentenyl-diphosphate delta isomerase 1.	0.953
CYP51A1	INSIG1	ENSCPOP00000013149	ENSCPOP00000013279	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.568
CYP51A1	Insig2	ENSCPOP00000013149	ENSCPOP00000025935	Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.489