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MYLK MYLK PLA2G6 PLA2G6 PDE4D PDE4D CACNA1C CACNA1C ATP2B4 ATP2B4 HTR7 HTR7 SULF2 SULF2 HTR1D HTR1D RAP1GDS1 RAP1GDS1 DRD1 DRD1 Sstr2 Sstr2 SULF1 SULF1 TBX2 TBX2 PTGER3 PTGER3 GDNF GDNF KCNMA1 KCNMA1 FKBP1B FKBP1B MKKS MKKS EDN3 EDN3 EDN1 EDN1 Chrnb2 Chrnb2 TSHZ3 TSHZ3 SMPD3 SMPD3 TBXA2R TBXA2R HTR2B HTR2B TPCN2 TPCN2 BBS2 BBS2 TBX3 TBX3 EDNRA EDNRA APBB2 APBB2 DRD2 DRD2 TRPV1 TRPV1 EDN2 EDN2 Trpa1 Trpa1 ACTA2 ACTA2 ROCK2 ROCK2 LOC100730761 LOC100730761 Scnn1b Scnn1b P2RX2 P2RX2 EDNRB EDNRB APBB1 APBB1 P2RX3 P2RX3 H0VYS9_CAVPO H0VYS9_CAVPO Chrm3 Chrm3 COMP COMP ADRB2 ADRB2 BDKRB2 BDKRB2 CHRNB4 CHRNB4 NEUROG1 NEUROG1 CACNA1G CACNA1G GRIP2 GRIP2 H0WDB6_CAVPO H0WDB6_CAVPO AGT AGT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYLKMyosin light chain kinase. (1959 aa)
PLA2G6Phospholipase A2 group VI. (803 aa)
PDE4DPhosphodiesterase. (782 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
HTR75-hydroxytryptamine receptor 7; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (337 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (872 aa)
HTR1D5-hydroxytryptamine receptor 1D; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitte [...] (376 aa)
RAP1GDS1Rap1 GTPase-GDP dissociation stimulator 1. (606 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Sstr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (368 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (869 aa)
TBX2T-box transcription factor 2. (686 aa)
PTGER3Prostaglandin E receptor 3. (363 aa)
GDNFGlial cell derived neurotrophic factor. (210 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
EDN3Endothelin 3. (200 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
Chrnb2Uncharacterized protein. (499 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1081 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (656 aa)
TBXA2RThromboxane A2 receptor. (347 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
TPCN2Two pore channel 2. (752 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
TBX3T-box transcription factor 3. (739 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (399 aa)
APBB2Amyloid beta precursor protein binding family B member 2. (761 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
EDN2Endothelin 2. (179 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
Scnn1bUncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (640 aa)
P2RX2P2X purinoceptor 2; Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity); Belongs to the P2X receptor family. (411 aa)
EDNRBEndothelin receptor type B; Belongs to the G-protein coupled receptor 1 family. (415 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (709 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (391 aa)
H0VYS9_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)
Chrm3Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
BDKRB2B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (399 aa)
CHRNB4Cholinergic receptor nicotinic beta 4 subunit. (489 aa)
NEUROG1Neurogenin 1. (241 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2372 aa)
GRIP2Glutamate receptor interacting protein 2. (1004 aa)
H0WDB6_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (288 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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