STRINGSTRING
RHOBTB3 RHOBTB3 LLGL1 LLGL1 ACTR3B ACTR3B HSP90AB1 HSP90AB1 NSFL1C NSFL1C FAM193A FAM193A UST UST DYNLT1 DYNLT1 PARD3B PARD3B GBF1 GBF1 PAK1 PAK1 PDZD11 PDZD11 MYH9 MYH9 RAB11FIP2 RAB11FIP2 TTC8 TTC8 FOXF1 FOXF1 KIF26B KIF26B PRICKLE2 PRICKLE2 LIN7A LIN7A APC APC SNAP91 SNAP91 Hsp90aa1 Hsp90aa1 EPHB1 EPHB1 CRTAM CRTAM H0UYD4_CAVPO H0UYD4_CAVPO LIN7B LIN7B CCL19 CCL19 PDLIM1 PDLIM1 Spag5 Spag5 WEE1 WEE1 FEZ1 FEZ1 TSC2 TSC2 PKD1 PKD1 Pdcd6ip Pdcd6ip MPP5 MPP5 LRRC1 LRRC1 WNT7A WNT7A EZR EZR DLG1 DLG1 SPRY1 SPRY1 CEP290 CEP290 ACTR3 ACTR3 ENSCPOP00000032677 ENSCPOP00000032677 FGF13 FGF13 ENSCPOP00000032481 ENSCPOP00000032481 RHOBTB2 RHOBTB2 NT5DC3 NT5DC3 ENSCPOP00000032025 ENSCPOP00000032025 Misp Misp MAD2L1 MAD2L1 ITGB1 ITGB1 CDC42 CDC42 ENSCPOP00000031438 ENSCPOP00000031438 SPRY2 SPRY2 RAB10 RAB10 MSN MSN RHOA RHOA FBXW11 FBXW11 SHH SHH KIF2C KIF2C PLK1 PLK1 TCIRG1 TCIRG1 KIAA1614 KIAA1614 OPHN1 OPHN1 GOLPH3 GOLPH3 LIN7C LIN7C RHOF RHOF PTK7 PTK7 Clasp2 Clasp2 FAM89B FAM89B ENSCPOP00000029904 ENSCPOP00000029904 DOCK2 DOCK2 CLASP1 CLASP1 RHOJ RHOJ SYNJ2BP SYNJ2BP CYTH1 CYTH1 CENPA CENPA TMEM114 TMEM114 PARVA PARVA ENSCPOP00000028385 ENSCPOP00000028385 ENSCPOP00000028355 ENSCPOP00000028355 ENSCPOP00000028111 ENSCPOP00000028111 IFT20 IFT20 DLG3 DLG3 ENSCPOP00000027886 ENSCPOP00000027886 CRKL CRKL Map2 Map2 MYO18A MYO18A SCRIB SCRIB FRMD4A FRMD4A HEY1 HEY1 FOXJ1 FOXJ1 MYO9A MYO9A RHOBTB1 RHOBTB1 RHOH RHOH Lims1 Lims1 RND2 RND2 DOCK7 DOCK7 Mapre1 Mapre1 SLC9A3R1 SLC9A3R1 Arf4 Arf4 STK11 STK11 ENSCPOP00000025438 ENSCPOP00000025438 PAM16 PAM16 PARD6G PARD6G MAP4 MAP4 HES5 HES5 ARPC5 ARPC5 BRSK2 BRSK2 HTT HTT WNT5A WNT5A NT5DC2 NT5DC2 FAT1 FAT1 RND3 RND3 LOC100725824 LOC100725824 ENSCPOP00000022761 ENSCPOP00000022761 ARHGEF2 ARHGEF2 FGF10 FGF10 Sh3bp1 Sh3bp1 KAT5 KAT5 RAC1 RAC1 ALPK2 ALPK2 FBF1 FBF1 CYTH3 CYTH3 ACTB ACTB PAFAH1B1 PAFAH1B1 ENSCPOP00000022108 ENSCPOP00000022108 CKAP5 CKAP5 ACTR2 ACTR2 SIPA1L3 SIPA1L3 MTCL1 MTCL1 FRMD4B FRMD4B HES1 HES1 RND1 RND1 EXOC4 EXOC4 RHOV RHOV CAMSAP3 CAMSAP3 H0WD09_CAVPO H0WD09_CAVPO PARD6B PARD6B STK25 STK25 UBXN2B UBXN2B PATJ PATJ H0W9K9_CAVPO H0W9K9_CAVPO H0W7V2_CAVPO H0W7V2_CAVPO CD3G CD3G H0W5D4_CAVPO H0W5D4_CAVPO NDE1 NDE1 RHOU RHOU H0W3Y7_CAVPO H0W3Y7_CAVPO LHX2 LHX2 H0W1P6_CAVPO H0W1P6_CAVPO PARVG PARVG H0W0B4_CAVPO H0W0B4_CAVPO MYO9B MYO9B MOS MOS H0VYG8_CAVPO H0VYG8_CAVPO LMNA LMNA H0VXT9_CAVPO H0VXT9_CAVPO GPSM1 GPSM1 H0VWH7_CAVPO H0VWH7_CAVPO RHOD RHOD NCKAP1 NCKAP1 H0VVE5_CAVPO H0VVE5_CAVPO RHOG RHOG H0VUM6_CAVPO H0VUM6_CAVPO PARVB PARVB Nphp3 Nphp3 PARD3 PARD3 MCPH1 MCPH1 SDCCAG8 SDCCAG8 PRKCI PRKCI WNT7B WNT7B FERMT1 FERMT1 RHOC RHOC GSK3B GSK3B RAC3 RAC3 PRKCZ PRKCZ Coro7 Coro7 LAMA1 LAMA1 ARHGAP35 ARHGAP35 TCF15 TCF15 RPGRIP1L RPGRIP1L NDEL1 NDEL1 TRAF3IP2 TRAF3IP2 Dctn1 Dctn1 ILK ILK SYNE4 SYNE4 TMEM53 TMEM53 Aqp1 Aqp1 DLG2 DLG2 SPDL1 SPDL1 PARD6A PARD6A CARMIL2 CARMIL2 MACF1 MACF1 PKHD1 PKHD1 VANGL2 VANGL2 CRB2 CRB2 H0VFY3_CAVPO H0VFY3_CAVPO INSC INSC LRRC7 LRRC7 H0VEL3_CAVPO H0VEL3_CAVPO SPINT2 SPINT2 SAPCD2 SAPCD2 WNT11 WNT11 BRSK1 BRSK1 NUMA1 NUMA1 NCKAP1L NCKAP1L ARF6 ARF6 RHOQ RHOQ FSCN1 FSCN1 CDK5RAP2 CDK5RAP2 PAX6 PAX6 FSCN2 FSCN2 CRK CRK AMOTL2 AMOTL2 JAM3 JAM3 CYP26B1 CYP26B1 AMOTL1 AMOTL1 MAP1B MAP1B NDC80 NDC80 FSCN3 FSCN3 CCL21 CCL21 IGF1R IGF1R DLG5 DLG5 ZW10 ZW10 DST DST NEK3 NEK3 ANKFN1 ANKFN1 WDR1 WDR1 AMOT AMOT LLGL2 LLGL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RHOBTB3Rho related BTB domain containing 3. (610 aa)
LLGL1LLGL scribble cell polarity complex component 1. (1044 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (417 aa)
HSP90AB1Heat shock protein 90 alpha family class B member 1. (723 aa)
NSFL1CNSFL1 cofactor. (372 aa)
FAM193AFamily with sequence similarity 193 member A. (1422 aa)
USTUronyl 2-sulfotransferase. (342 aa)
DYNLT1Dynein light chain Tctex-type 1. (113 aa)
PARD3BPar-3 family cell polarity regulator beta. (1026 aa)
GBF1Golgi brefeldin A resistant guanine nucleotide exchange factor 1. (1856 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PDZD11PDZ domain containing 11. (140 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
RAB11FIP2RAB11 family interacting protein 2. (523 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
FOXF1Forkhead box F1. (376 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2100 aa)
PRICKLE2Prickle planar cell polarity protein 2. (901 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (205 aa)
APCAPC regulator of WNT signaling pathway. (2842 aa)
SNAP91Synaptosome associated protein 91. (896 aa)
Hsp90aa1Heat shock protein 90 alpha family class A member 1. (733 aa)
EPHB1EPH receptor B1. (736 aa)
CRTAMCytotoxic and regulatory T cell molecule. (383 aa)
H0UYD4_CAVPOKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (552 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
CCL19C-C motif chemokine. (107 aa)
PDLIM1PDZ and LIM domain 1. (328 aa)
Spag5Sperm associated antigen 5. (1196 aa)
WEE1Wee1-like protein kinase. (612 aa)
FEZ1Fasciculation and elongation protein zeta 1. (403 aa)
TSC2TSC complex subunit 2. (1745 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
Pdcd6ipBRO1 domain-containing protein. (872 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LRRC1Leucine rich repeat containing 1. (458 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
EZREzrin. (586 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (886 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
CEP290Centrosomal protein 290. (2425 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (411 aa)
ENSCPOP00000032677Eph LBD domain-containing protein. (286 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ENSCPOP00000032481Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
RHOBTB2Rho related BTB domain containing 2. (727 aa)
NT5DC35'-nucleotidase domain containing 3. (497 aa)
ENSCPOP00000032025Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
MispUncharacterized protein. (774 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
CDC42Cell division cycle 42. (191 aa)
ENSCPOP00000031438annotation not available (62 aa)
SPRY2Sprouty RTK signaling antagonist 2. (316 aa)
RAB10RAB10, member RAS oncogene family. (211 aa)
MSNMoesin. (577 aa)
RHOARas homolog family member A. (193 aa)
FBXW11F-box and WD repeat domain containing 11. (530 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
KIF2CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (725 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
KIAA1614KIAA1614. (1211 aa)
OPHN1Uncharacterized protein. (802 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
RHOFRas homolog family member F, filopodia associated. (205 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1063 aa)
Clasp2Uncharacterized protein. (1497 aa)
FAM89BFamily with sequence similarity 89 member B. (189 aa)
ENSCPOP00000029904Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (633 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1843 aa)
CLASP1Cytoplasmic linker associated protein 1. (1524 aa)
RHOJRas homolog family member J. (216 aa)
SYNJ2BPSynaptojanin 2 binding protein. (145 aa)
CYTH1Cytohesin 1. (400 aa)
CENPACentromere protein A. (131 aa)
TMEM114Transmembrane protein 114. (223 aa)
PARVAParvin alpha. (347 aa)
ENSCPOP00000028385TPR_REGION domain-containing protein. (154 aa)
ENSCPOP00000028355Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (631 aa)
ENSCPOP00000028111Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
IFT20Intraflagellar transport 20. (132 aa)
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (850 aa)
ENSCPOP00000027886Uncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
Map2Microtubule-associated protein. (559 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2083 aa)
SCRIBScribble planar cell polarity protein. (1653 aa)
FRMD4AFERM domain containing 4A. (1051 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
FOXJ1Forkhead box J1. (422 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2603 aa)
RHOBTB1Rho related BTB domain containing 1. (696 aa)
RHOHRas homolog family member H. (191 aa)
Lims1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (396 aa)
RND2Rho family GTPase 2. (227 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (2006 aa)
Mapre1Uncharacterized protein. (268 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (358 aa)
Arf4Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
ENSCPOP00000025438Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (589 aa)
PAM16Presequence translocase associated motor 16. (121 aa)
PARD6GPar-6 family cell polarity regulator gamma. (382 aa)
MAP4Microtubule-associated protein. (1128 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
BRSK2BR serine/threonine kinase 2. (718 aa)
HTTHuntingtin. (3133 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NT5DC25'-nucleotidase domain containing 2. (557 aa)
FAT1FAT atypical cadherin 1. (4558 aa)
RND3Rho family GTPase 3. (244 aa)
LOC100725824HATPase_c domain-containing protein. (695 aa)
ENSCPOP00000022761Uncharacterized protein; Belongs to the protein kinase superfamily. (451 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (986 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
Sh3bp1Uncharacterized protein. (684 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
RAC1Ras-related C3 botulinum toxin substrate 1. (211 aa)
ALPK2Alpha kinase 2. (2148 aa)
FBF1Fas binding factor 1. (1130 aa)
CYTH3Cytohesin 3. (399 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
ENSCPOP00000022108Uncharacterized protein; Belongs to the protein kinase superfamily. (348 aa)
CKAP5Cytoskeleton associated protein 5. (2032 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
SIPA1L3Signal induced proliferation associated 1 like 3. (1774 aa)
MTCL1Microtubule crosslinking factor 1. (1642 aa)
FRMD4BFERM domain containing 4B. (1024 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
RND1Rho family GTPase 1. (232 aa)
EXOC4Exocyst complex component 4. (975 aa)
RHOVRas homolog family member V. (236 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1210 aa)
H0WD09_CAVPONon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (323 aa)
PARD6BPar-6 family cell polarity regulator beta. (357 aa)
STK25Serine/threonine kinase 25. (426 aa)
UBXN2BUBX domain protein 2B. (328 aa)
PATJPATJ crumbs cell polarity complex component. (1884 aa)
H0W9K9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
H0W7V2_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (555 aa)
CD3GCD3g molecule. (181 aa)
H0W5D4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (455 aa)
NDE1NudE neurodevelopment protein 1. (350 aa)
RHOURas homolog family member U. (170 aa)
H0W3Y7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (503 aa)
LHX2LIM homeobox 2. (406 aa)
H0W1P6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (539 aa)
PARVGParvin gamma. (223 aa)
H0W0B4_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (639 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1930 aa)
MOSMOS proto-oncogene, serine/threonine kinase; Belongs to the protein kinase superfamily. (357 aa)
H0VYG8_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
H0VXT9_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (546 aa)
GPSM1G protein signaling modulator 1. (706 aa)
H0VWH7_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (441 aa)
RHODRas homolog family member D. (204 aa)
NCKAP1NCK associated protein 1. (1140 aa)
H0VVE5_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (528 aa)
RHOGRas homolog family member G. (191 aa)
H0VUM6_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (552 aa)
PARVBParvin beta. (365 aa)
Nphp3TPR_REGION domain-containing protein. (1281 aa)
PARD3Par-3 family cell polarity regulator. (1294 aa)
MCPH1Uncharacterized protein. (786 aa)
SDCCAG8Serologically defined colon cancer antigen 8. (714 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (572 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
FERMT1Fermitin family member 1. (676 aa)
RHOCRas homolog family member C. (193 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
RAC3Rac family small GTPase 3. (192 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (593 aa)
Coro7Coronin; Belongs to the WD repeat coronin family. (923 aa)
LAMA1Laminin subunit alpha 1. (3018 aa)
ARHGAP35Rho GTPase activating protein 35. (1500 aa)
TCF15Transcription factor 15. (188 aa)
RPGRIP1LRPGRIP1 like. (1260 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (345 aa)
TRAF3IP2TRAF3 interacting protein 2. (561 aa)
Dctn1CAP-Gly domain-containing protein. (1281 aa)
ILKIntegrin-linked protein kinase; Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. (452 aa)
SYNE4Spectrin repeat containing nuclear envelope family member 4. (390 aa)
TMEM53Transmembrane protein 53. (278 aa)
Aqp1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
DLG2Discs large MAGUK scaffold protein 2. (870 aa)
SPDL1Protein Spindly; Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment. (606 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1372 aa)
MACF1Microtubule actin crosslinking factor 1. (7286 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4024 aa)
VANGL2Vang-like protein. (548 aa)
CRB2Crumbs cell polarity complex component 2. (1242 aa)
H0VFY3_CAVPOUncharacterized protein. (674 aa)
INSCINSC spindle orientation adaptor protein. (532 aa)
LRRC7Leucine rich repeat containing 7. (1504 aa)
H0VEL3_CAVPOEB1 C-terminal domain-containing protein. (254 aa)
SPINT2Serine peptidase inhibitor, Kunitz type 2. (252 aa)
SAPCD2Suppressor APC domain containing 2. (382 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
BRSK1BR serine/threonine kinase 1. (763 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2117 aa)
NCKAP1LNCK associated protein 1 like. (1111 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RHOQRas homolog family member Q. (195 aa)
FSCN1Fascin. (493 aa)
CDK5RAP2CDK5 regulatory subunit associated protein 2. (1868 aa)
PAX6Paired box 6. (436 aa)
FSCN2Fascin. (492 aa)
CRKCRK proto-oncogene, adaptor protein. (281 aa)
AMOTL2Angiomotin like 2. (772 aa)
JAM3Junctional adhesion molecule 3. (310 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
AMOTL1Angiomotin like 1. (955 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
NDC80NDC80 kinetochore complex component. (644 aa)
FSCN3Fascin. (498 aa)
CCL21C-C motif chemokine ligand 21. (126 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1864 aa)
ZW10Zw10 kinetochore protein. (778 aa)
DSTDystonin. (5380 aa)
NEK3NIMA related kinase 3; Belongs to the protein kinase superfamily. (467 aa)
ANKFN1Ankyrin repeat and fibronectin type III domain containing 1. (763 aa)
WDR1WD_REPEATS_REGION domain-containing protein. (600 aa)
AMOTAngiomotin. (1089 aa)
LLGL2LLGL scribble cell polarity complex component 2. (1017 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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