STRINGSTRING
MCHR1 MCHR1 NPY1R NPY1R SSTR3 SSTR3 HCRT HCRT Rapgef2 Rapgef2 TACR1 TACR1 PTH2 PTH2 NTSR1 NTSR1 GLRB GLRB NPBWR1 NPBWR1 OPRD1 OPRD1 Ltb4r2 Ltb4r2 NPY2R NPY2R C4orf48 C4orf48 PENK PENK NXPH1 NXPH1 QRFP QRFP PNOC PNOC PROKR2 PROKR2 PROKR1 PROKR1 PROK2 PROK2 Sstr2 Sstr2 NPFF NPFF SCG5 SCG5 GPR83 GPR83 ECEL1 ECEL1 NXPH3 NXPH3 CARTPT CARTPT H0WDB6_CAVPO H0WDB6_CAVPO NPFFR1 NPFFR1 POMC POMC GPR84 GPR84 PDYN PDYN LOC100725331 LOC100725331 Npy5r Npy5r NPY NPY GRP GRP TENM1 TENM1 PYY PYY GPR139 GPR139 MC2R MC2R PTGDR2 PTGDR2 SSTR5 SSTR5 NPS NPS RELA RELA Ppyr1 Ppyr1 LTB4R LTB4R SSTR1 SSTR1 H0VYS9_CAVPO H0VYS9_CAVPO OPRM1 OPRM1 NPPA NPPA Kiss1r Kiss1r CYSLTR2 CYSLTR2 TACR3 TACR3 GLRA4 GLRA4 GLP1R GLP1R SORL1 SORL1 ADCYAP1 ADCYAP1 NPBWR2 NPBWR2 BRS3 BRS3 GPR37 GPR37 NPVF NPVF GLRA1 GLRA1 NMB NMB GALR1 GALR1 GRPR GRPR QRFPR QRFPR NMBR NMBR SORT1 SORT1 NXPH2 NXPH2 NMS NMS GAL GAL H0V3A7_CAVPO H0V3A7_CAVPO H0V3F2_CAVPO H0V3F2_CAVPO H0V5P5_CAVPO H0V5P5_CAVPO NPSR1 NPSR1 TACR2 TACR2 HCRTR2 HCRTR2 NTS NTS Uts2r Uts2r HCRTR1 HCRTR1 PRLHR PRLHR GPR143 GPR143 PCSK1N PCSK1N NMU NMU GLRA2 GLRA2 GPR149 GPR149 TYRO3 TYRO3 Nmur2 Nmur2 PMCH PMCH AGRP AGRP TAC1 TAC1 GLRA3 GLRA3 TAC3 TAC3 GPR171 GPR171
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MCHR1Melanin concentrating hormone receptor 1. (355 aa)
NPY1RNeuropeptide Y receptor type 1; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (394 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (432 aa)
HCRTHypocretin neuropeptide precursor. (110 aa)
Rapgef2Uncharacterized protein. (1640 aa)
TACR1Substance-P receptor; This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K. (407 aa)
PTH2Parathyroid hormone 2. (140 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (412 aa)
GLRBGlycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
NPBWR1Neuropeptides B and W receptor 1; Belongs to the G-protein coupled receptor 1 family. (271 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
Ltb4r2G_PROTEIN_RECEP_F1_2 domain-containing protein. (360 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (381 aa)
C4orf48Chromosome 4 open reading frame 48. (94 aa)
PENKMet-enkephalin-Arg-Gly-Leu; Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(238-259) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. (268 aa)
NXPH1Neurexophilin; May be signaling molecules that resemble neuropeptides. (271 aa)
QRFPPyroglutamylated RFamide peptide. (125 aa)
PNOCPrepronociceptin. (176 aa)
PROKR2Prokineticin receptor 2; Belongs to the G-protein coupled receptor 1 family. (384 aa)
PROKR1Prokineticin receptor 1; Belongs to the G-protein coupled receptor 1 family. (393 aa)
PROK2Prokineticin 2. (131 aa)
Sstr2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (368 aa)
NPFFNeuropeptide FF-amide peptide precursor. (109 aa)
SCG5Secretogranin V. (212 aa)
GPR83G protein-coupled receptor 83; Belongs to the G-protein coupled receptor 1 family. (423 aa)
ECEL1Endothelin converting enzyme like 1. (765 aa)
NXPH3Neurexophilin; May be signaling molecules that resemble neuropeptides. (253 aa)
CARTPTCART prepropeptide. (129 aa)
H0WDB6_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (288 aa)
NPFFR1Neuropeptide FF receptor 1; Belongs to the G-protein coupled receptor 1 family. (436 aa)
POMCCorticotropin-like intermediary peptide; ACTH stimulates the adrenal glands to release cortisol. Beta-endorphin and Met-enkephalin are endogenous opiates. [Melanocyte-stimulating hormone alpha]: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. [Beta-endorphin]: Endogenous orexigenic opiate. (342 aa)
GPR84G protein-coupled receptor 84. (396 aa)
PDYNAlpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. (245 aa)
LOC100725331Uncharacterized protein. (1433 aa)
Npy5rNPY receptor 5. (446 aa)
NPYNeuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity); Belongs to the bombesin/neuromedin-B/ranatensin family. (143 aa)
TENM1Teneurin transmembrane protein 1. (2732 aa)
PYYPeptide YY. (100 aa)
GPR139G protein-coupled receptor 139. (349 aa)
MC2RAdrenocorticotropic hormone receptor; Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). (297 aa)
PTGDR2Chemoattractant receptor-homologous molecule expressed on Th2 cells; Belongs to the G-protein coupled receptor 1 family. (391 aa)
SSTR5Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
NPSNeuropeptide S. (72 aa)
RELARELA proto-oncogene, NF-kB subunit. (549 aa)
Ppyr1Pancreatic polypeptide receptor Y4; Belongs to the G-protein coupled receptor 1 family. (372 aa)
LTB4RLeukotriene B4 receptor; Belongs to the G-protein coupled receptor 1 family. (348 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
H0VYS9_CAVPOG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)
OPRM1Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP- bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell ty [...] (416 aa)
NPPACardiodilatin-related peptide; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity). (223 aa)
Kiss1rG_PROTEIN_RECEP_F1_2 domain-containing protein. (363 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (317 aa)
TACR3Neuromedin-K receptor; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (404 aa)
GLRA4Glycine receptor alpha 4; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
SORL1Sortilin related receptor 1. (2211 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (180 aa)
NPBWR2Neuropeptides B and W receptor 2; Belongs to the G-protein coupled receptor 1 family. (336 aa)
BRS3Bombesin receptor subtype-3; Role in sperm cell division, maturation, or function. The relative order of ligand affinity is GRP = neuromedin-C >> neuromedin- B. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (399 aa)
GPR37G protein-coupled receptor 37. (606 aa)
NPVFNeuropeptide VF precursor. (190 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
NMBNeuromedin B. (119 aa)
GALR1Galanin receptor 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
GRPRGastrin releasing peptide receptor; Belongs to the G-protein coupled receptor 1 family. (383 aa)
QRFPRPyroglutamylated RFamide peptide receptor; Belongs to the G-protein coupled receptor 1 family. (431 aa)
NMBRNeuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
SORT1Sortilin. (759 aa)
NXPH2Neurexophilin; May be signaling molecules that resemble neuropeptides. (264 aa)
NMSNeuromedin S. (150 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
H0V3A7_CAVPOUncharacterized protein. (1320 aa)
H0V3F2_CAVPOUncharacterized protein. (1365 aa)
H0V5P5_CAVPOUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa)
NPSR1Neuropeptide S receptor 1. (377 aa)
TACR2Substance-K receptor; This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (402 aa)
HCRTR2Hypocretin receptor 2; Belongs to the G-protein coupled receptor 1 family. (448 aa)
NTSNeurotensin. (170 aa)
Uts2rG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (386 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (416 aa)
PRLHRProlactin releasing hormone receptor; Belongs to the G-protein coupled receptor 1 family. (370 aa)
GPR143G protein-coupled receptor 143. (407 aa)
PCSK1NProprotein convertase subtilisin/kexin type 1 inhibitor. (261 aa)
NMUNeuromedin-U-9. (171 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
GPR149G protein-coupled receptor 149. (724 aa)
TYRO3TYRO3 protein tyrosine kinase. (880 aa)
Nmur2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (403 aa)
PMCHPro-melanin concentrating hormone. (165 aa)
AGRPAgouti related neuropeptide. (132 aa)
TAC1Substance P. (129 aa)
GLRA3Glycine receptor alpha 3; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (464 aa)
TAC3Tachykinin 3. (125 aa)
GPR171G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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