STRINGSTRING
EXT2 EXT2 Itgb3 Itgb3 AXIN1 AXIN1 PRKAR1A PRKAR1A EOMES EOMES KDM6B KDM6B SMAD4 SMAD4 FGFR1 FGFR1 BMP4 BMP4 PALB2 PALB2 HNF1A HNF1A TBX19 TBX19 TBX3 TBX3 TXNRD1 TXNRD1 WLS WLS FOXF1 FOXF1 TBXT TBXT H0UXD4_CAVPO H0UXD4_CAVPO OSR1 OSR1 ZIC3 ZIC3 CHRD CHRD SETD2 SETD2 GPI GPI ACVR2A ACVR2A ACVR1 ACVR1 POGLUT1 POGLUT1 H0VDD3_CAVPO H0VDD3_CAVPO SMAD1 SMAD1 WNT11 WNT11 POFUT2 POFUT2 NUP133 NUP133 LDB1 LDB1 ARMC5 ARMC5 CRB2 CRB2 FOXH1 FOXH1 ITGA8 ITGA8 WNT3 WNT3 EPB41L5 EPB41L5 Prkaca Prkaca TWSG1 TWSG1 Apela Apela ITGB1 ITGB1 SFRP2 SFRP2 SHH SHH SMAD3 SMAD3 EPHA2 EPHA2 IRX3 IRX3 TBX6 TBX6 BMPR2 BMPR2 BMP7 BMP7 EYA1 EYA1 TEAD2 TEAD2 NR4A3 NR4A3 TP63 TP63 FGFR2 FGFR2 ACVR2B ACVR2B FOXA2 FOXA2 ITGB4 ITGB4 OVOL1 OVOL1 Gdf1 Gdf1 WNT3A WNT3A NF2 NF2 HTT HTT LEF1 LEF1 WNT5A WNT5A SSBP3 SSBP3 Inhba Inhba NOG NOG CTDNEP1 CTDNEP1 PAX2 PAX2 EXOC4 EXOC4 FOXC2 FOXC2 AMH AMH Pou5f1 Pou5f1 BMPR1A BMPR1A Gdf3 Gdf3 TLX2 TLX2 ZIC2 ZIC2 SNAI1 SNAI1 LHX2 LHX2 ECSIT ECSIT SCX SCX SRF SRF FGF8 FGF8 DKK1 DKK1 NCKAP1 NCKAP1 HAND1 HAND1 LHX1 LHX1 NODAL NODAL ITGA2 ITGA2 SIX2 SIX2 ETS2 ETS2 TCF7L1 TCF7L1 KDM6A KDM6A SMAD2 SMAD2 DLL3 DLL3 Etv2 Etv2 H0VN16_CAVPO H0VN16_CAVPO SMO SMO EXT1 EXT1 TCF15 TCF15 MSGN1 MSGN1 CITED2 CITED2 OTX2 OTX2 ITGA3 ITGA3 TBX1 TBX1 TAF10 TAF10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (717 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
AXIN1Axin 1. (863 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
EOMESEomesodermin. (697 aa)
KDM6BLysine demethylase 6B. (1467 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
BMP4Bone morphogenetic protein 4. (404 aa)
PALB2Partner and localizer of BRCA2. (1172 aa)
HNF1AHNF1 homeobox A. (628 aa)
TBX19T-box transcription factor 19. (446 aa)
TBX3T-box transcription factor 3. (739 aa)
TXNRD1Thioredoxin reductase 1. (499 aa)
WLSWnt ligand secretion mediator. (541 aa)
FOXF1Forkhead box F1. (376 aa)
TBXTT-box transcription factor T. (435 aa)
H0UXD4_CAVPOTGF_BETA_2 domain-containing protein. (359 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ZIC3Zic family member 3. (246 aa)
CHRDChordin. (892 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2565 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (489 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (508 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
H0VDD3_CAVPOHomeobox domain-containing protein. (286 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
POFUT2Protein O-fucosyltransferase 2. (429 aa)
NUP133Nucleoporin 133. (1154 aa)
LDB1LIM domain binding 1. (401 aa)
ARMC5Armadillo repeat containing 5. (905 aa)
CRB2Crumbs cell polarity complex component 2. (1242 aa)
FOXH1Forkhead box H1. (370 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (705 aa)
PrkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
ApelaUncharacterized protein. (54 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
EPHA2EPH receptor A2. (976 aa)
IRX3Iroquois homeobox 3. (484 aa)
TBX6T-box transcription factor 6. (436 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1035 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TEAD2TEA domain transcription factor 2. (452 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FGFR2Fibroblast growth factor receptor. (801 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
FOXA2Forkhead box A2. (459 aa)
ITGB4Integrin beta. (1815 aa)
OVOL1Ovo like transcriptional repressor 1. (253 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
NF2Neurofibromin 2. (591 aa)
HTTHuntingtin. (3133 aa)
LEF1Lymphoid enhancer binding factor 1. (396 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SSBP3Single stranded DNA binding protein 3. (540 aa)
InhbaTGF_BETA_2 domain-containing protein. (133 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (210 aa)
PAX2Paired box 2. (393 aa)
EXOC4Exocyst complex component 4. (975 aa)
FOXC2Forkhead box C2. (441 aa)
AMHAnti-Mullerian hormone. (560 aa)
Pou5f1POU domain protein. (361 aa)
BMPR1ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
Gdf3TGF_BETA_2 domain-containing protein. (359 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
ZIC2Zic family member 2. (523 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
LHX2LIM homeobox 2. (406 aa)
ECSITECSIT signalling integrator. (431 aa)
SCXScleraxis bHLH transcription factor. (199 aa)
SRFSerum response factor. (461 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (308 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (229 aa)
NCKAP1NCK associated protein 1. (1140 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
LHX1LIM homeobox 1. (406 aa)
NODALNodal growth differentiation factor. (351 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
SIX2SIX homeobox 2. (298 aa)
ETS2ETS proto-oncogene 2, transcription factor. (447 aa)
TCF7L1Transcription factor 7 like 1. (587 aa)
KDM6ALysine demethylase 6A. (1164 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
DLL3Delta like canonical Notch ligand 3. (708 aa)
Etv2ETS domain-containing protein. (153 aa)
H0VN16_CAVPOUncharacterized protein. (71 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TCF15Transcription factor 15. (188 aa)
MSGN1Mesogenin 1. (187 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (269 aa)
OTX2Orthodenticle homeobox 2. (289 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1048 aa)
TBX1T-box transcription factor 1. (360 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (177 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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