STRINGSTRING
ENPP4 ENPP4 STXBP3 STXBP3 WNT3A WNT3A SERPING1 SERPING1 F2RL3 F2RL3 PRSS56 PRSS56 F2RL1 F2RL1 F2R F2R PTPRJ PTPRJ SERPINE2 SERPINE2 HPS1 HPS1 STXBP1 STXBP1 HABP2 HABP2 PTPN6 PTPN6 CX3CL1 CX3CL1 ANO6 ANO6 P2ry12 P2ry12 P2RX1 P2RX1 F2 F2 RAB27A RAB27A LOC100732436 LOC100732436 NBEAL2 NBEAL2 SHH SHH CD40LG CD40LG BLOC1S3 BLOC1S3 BLOC1S6 BLOC1S6 HPS4 HPS4 H0UTW7_CAVPO H0UTW7_CAVPO AP3B1 AP3B1 CPB2 CPB2 PROS1 PROS1 PIK3CB PIK3CB MERTK MERTK PIP5K1C PIP5K1C F3 F3 UBASH3B UBASH3B LOC100723623 LOC100723623 ANXA7 ANXA7 F2RL2 F2RL2 FERMT3 FERMT3 FIBP FIBP PAPSS2 PAPSS2 PEAR1 PEAR1 FGA FGA PLEK PLEK ENTPD1 ENTPD1 TREML1 TREML1 HPS5 HPS5 KLKB1 KLKB1 PROCR PROCR F13A1 F13A1 F7 F7 F10 F10 MMRN1 MMRN1 HPS6 HPS6 MPL MPL VKORC1 VKORC1 HNF4A HNF4A F5 F5 GAS6 GAS6 GATA1 GATA1 F8 F8 AXL AXL FGG FGG FBLN1 FBLN1 FGB FGB H0VE70_CAVPO H0VE70_CAVPO DTNBP1 DTNBP1 TYRO3 TYRO3 ANXA13 ANXA13 PDIA6 PDIA6 LNPK LNPK Itgb3 Itgb3 LYST LYST PLG PLG PDGFRA PDGFRA FZD6 FZD6 APOH APOH LOC100733338 LOC100733338 SERPIND1 SERPIND1 KNG1 KNG1 FN1 FN1 PROC PROC F11 F11 SLC7A11 SLC7A11 GNA13 GNA13 SERPINA10 SERPINA10 PROZ PROZ TFPI2 TFPI2 HGFAC HGFAC P2RY1 P2RY1 ENTPD2 ENTPD2 ADRA2B ADRA2B SRF SRF GP1BB GP1BB SLC4A1 SLC4A1 F9 F9 TSPAN32 TSPAN32 MPIG6B MPIG6B P2RY11 P2RY11 COMP COMP HRG HRG GP9 GP9 RAP2B RAP2B ADRA2A ADRA2A F12 F12 THBD THBD C1GALT1C1 C1GALT1C1 ZNF385A ZNF385A LOC100732158 LOC100732158 ANXA5 ANXA5 ENSCPOP00000023625 ENSCPOP00000023625
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENPP4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (478 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (328 aa)
SERPING1SERPIN domain-containing protein; Belongs to the serpin family. (578 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (381 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (572 aa)
F2RL1F2R like trypsin receptor 1. (399 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (426 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1311 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
HPS1HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (714 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
HABP2Hyaluronan binding protein 2. (501 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (396 aa)
ANO6Anoctamin. (922 aa)
P2ry12Uncharacterized protein. (114 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (664 aa)
RAB27ARAB27A, member RAS oncogene family. (220 aa)
LOC100732436Uncharacterized protein. (327 aa)
NBEAL2Neurobeachin like 2. (2739 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (447 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (199 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (167 aa)
HPS4HPS4 biogenesis of lysosomal organelles complex 3 subunit 2. (707 aa)
H0UTW7_CAVPOSERPIN domain-containing protein; Belongs to the serpin family. (93 aa)
AP3B1Adaptor related protein complex 3 subunit beta 1. (1276 aa)
CPB2Carboxypeptidase B2. (423 aa)
PROS1Protein S. (675 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1018 aa)
MERTKMER proto-oncogene, tyrosine kinase. (852 aa)
PIP5K1CPhosphatidylinositol-4-phosphate 5-kinase type 1 gamma. (689 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (289 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (638 aa)
LOC100723623Annexin. (327 aa)
ANXA7Annexin. (456 aa)
F2RL2Coagulation factor II thrombin receptor like 2. (329 aa)
FERMT3Fermitin family member 3. (663 aa)
FIBPFGF1 intracellular binding protein. (364 aa)
PAPSS2Uncharacterized protein. (621 aa)
PEAR1Platelet endothelial aggregation receptor 1. (1040 aa)
FGAFibrinogen alpha chain. (775 aa)
PLEKPleckstrin. (350 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (511 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (327 aa)
HPS5Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1129 aa)
KLKB1Kallikrein B1; Belongs to the peptidase S1 family. (504 aa)
PROCRProtein C receptor. (251 aa)
F13A1Coagulation factor XIII A chain. (731 aa)
F7Coagulation factor VII. (441 aa)
F10Coagulation factor X. (487 aa)
MMRN1Multimerin 1. (1215 aa)
HPS6HPS6 biogenesis of lysosomal organelles complex 2 subunit 3. (759 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1. (163 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (1990 aa)
GAS6Growth arrest specific 6. (678 aa)
GATA1GATA binding protein 1. (401 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2350 aa)
AXLAXL receptor tyrosine kinase. (888 aa)
FGGFibrinogen gamma chain. (445 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (697 aa)
FGBFibrinogen beta chain. (479 aa)
H0VE70_CAVPOUncharacterized protein. (796 aa)
DTNBP1Dystrobrevin binding protein 1. (354 aa)
TYRO3TYRO3 protein tyrosine kinase. (880 aa)
ANXA13Annexin. (315 aa)
PDIA6Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (445 aa)
LNPKLunapark, ER junction formation factor. (350 aa)
Itgb3Integrin beta; Belongs to the integrin beta chain family. (735 aa)
LYSTLysosomal trafficking regulator. (3688 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (644 aa)
APOHApolipoprotein H. (235 aa)
LOC100733338Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (278 aa)
SERPIND1Serpin family D member 1; Belongs to the serpin family. (478 aa)
KNG1Kininogen 1. (625 aa)
FN1Fibronectin 1. (2478 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (464 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (650 aa)
SLC7A11Solute carrier family 7 member 11. (507 aa)
GNA13G protein subunit alpha 13. (377 aa)
SERPINA10Serpin family A member 10; Belongs to the serpin family. (442 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (406 aa)
TFPI2Tissue factor pathway inhibitor. (243 aa)
HGFACHGF activator. (641 aa)
P2RY1P2Y purinoceptor 1; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation. Belongs to the G-protein coupled receptor 1 family. (373 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
ADRA2BAlpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (449 aa)
SRFSerum response factor. (461 aa)
GP1BBGlycoprotein Ib platelet subunit beta. (212 aa)
SLC4A1Anion exchange protein. (901 aa)
F9Coagulation factor IX; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (472 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (265 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (241 aa)
P2RY11Purinergic receptor P2Y11; Belongs to the G-protein coupled receptor 1 family. (408 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
HRGHistidine rich glycoprotein. (467 aa)
GP9Glycoprotein IX platelet. (181 aa)
RAP2BRAP2B, member of RAS oncogene family. (183 aa)
ADRA2AAlpha-2A adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). (402 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (617 aa)
THBDThrombomodulin. (534 aa)
C1GALT1C1C1GALT1 specific chaperone 1. (318 aa)
ZNF385AZinc finger protein 385A. (386 aa)
LOC100732158Uncharacterized protein. (246 aa)
ANXA5Annexin. (318 aa)
ENSCPOP00000023625Uncharacterized protein. (104 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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