STRINGSTRING
SYNPO SYNPO CSMD2 CSMD2 PAK1 PAK1 ASIC1 ASIC1 NPAS4 NPAS4 NRXN2 NRXN2 Pde8b Pde8b LGMN LGMN ABCC8 ABCC8 UBA6 UBA6 HTR6 HTR6 PRKAR2B PRKAR2B DRD3 DRD3 SNAP25 SNAP25 SYNGAP1 SYNGAP1 DCDC2 DCDC2 RGS14 RGS14 GABRA5 GABRA5 HMGCR HMGCR TSC1 TSC1 COMT COMT SYT11 SYT11 BCHE BCHE HIF1A HIF1A H0V5P5_CAVPO H0V5P5_CAVPO PTRHD1 PTRHD1 ADCY3 ADCY3 GIT1 GIT1 GABRB3 GABRB3 PPT1 PPT1 Kmt2a Kmt2a H0V6I7_CAVPO H0V6I7_CAVPO ABL1 ABL1 UBE3A UBE3A DEAF1 DEAF1 GRIN2B GRIN2B NF1 NF1 CHST10 CHST10 AMPH AMPH NTS NTS LRRN4 LRRN4 CHRD CHRD PTGS1 PTGS1 ZZEF1 ZZEF1 TNR TNR TANC1 TANC1 PTN PTN PPP1R1B PPP1R1B DRD2 DRD2 NETO1 NETO1 SHANK2 SHANK2 SLC8A2 SLC8A2 ABCA7 ABCA7 YTHDF1 YTHDF1 VDAC3 VDAC3 Atp1a3 Atp1a3 EPHB2 EPHB2 KIT KIT MTOR MTOR CNTN2 CNTN2 PGRMC1 PGRMC1 KALRN KALRN MECP2 MECP2 TH TH SLC1A1 SLC1A1 SLC7A11 SLC7A11 LOC100730761 LOC100730761 ABL2 ABL2 GRIN2A GRIN2A IDUA IDUA EN1 EN1 SORCS3 SORCS3 DDHD2 DDHD2 CACNA1E CACNA1E TACO1 TACO1 PDE1B PDE1B H0VSR6_CAVPO H0VSR6_CAVPO GLP1R GLP1R CSMD1 CSMD1 STRA6 STRA6 RIC8A RIC8A DKK1 DKK1 SHANK3 SHANK3 H0VXJ2_CAVPO H0VXJ2_CAVPO SRF SRF CTNND2 CTNND2 NPS NPS GRM7 GRM7 H0W1V8_CAVPO H0W1V8_CAVPO SLC6A1 SLC6A1 HRH1 HRH1 TPBG TPBG H0W426_CAVPO H0W426_CAVPO DBH DBH PAK6 PAK6 ADAM2 ADAM2 CTNS CTNS SHANK1 SHANK1 AP1S2 AP1S2 ATXN1 ATXN1 RIN1 RIN1 ARC ARC MAP1A MAP1A RAG1 RAG1 NPTX2 NPTX2 TLR2 TLR2 TTC36 TTC36 DRD5 DRD5 APP APP JPH4 JPH4 JUN JUN FOXB1 FOXB1 Drd4 Drd4 AGT AGT NTRK2 NTRK2 CREB1 CREB1 DGKI DGKI SYNJ1 SYNJ1 CCK CCK ACTR2 ACTR2 CKAP5 CKAP5 ADGRB3 ADGRB3 ENSCPOP00000022335 ENSCPOP00000022335 NOG NOG NPTN NPTN NLGN3 NLGN3 CACNA1C CACNA1C FOSL1 FOSL1 PLCB1 PLCB1 BTG2 BTG2 ENSCPOP00000023749 ENSCPOP00000023749 ATP8A1 ATP8A1 Elavl4 Elavl4 HTT HTT RAPGEF3 RAPGEF3 DRD1 DRD1 Arf4 Arf4 Cln3 Cln3 GRIN1 GRIN1 NRGN NRGN EIF2AK4 EIF2AK4 CIC CIC ENSCPOP00000027747 ENSCPOP00000027747 NDRG4 NDRG4 IFT20 IFT20 NEUROD2 NEUROD2 SLC24A2 SLC24A2 Vdac1 Vdac1 PPP1R9B PPP1R9B SLC8A3 SLC8A3 B4GALT2 B4GALT2 Chrna7 Chrna7 ENSCPOP00000029147 ENSCPOP00000029147 SGK1 SGK1 ATP1A2 ATP1A2 CRH CRH TAFA2 TAFA2 Chrnb2 Chrnb2 FOXP2 FOXP2 MAPK8IP2 MAPK8IP2 GMFB GMFB SPECC1 SPECC1 ENSCPOP00000031438 ENSCPOP00000031438 Meis2 Meis2 BRAF BRAF RELN RELN ITGB1 ITGB1 ATXN1L ATXN1L Cln8 Cln8 ATAD1 ATAD1 EPM2A EPM2A FGF13 FGF13 CDK5 CDK5 NRXN3 NRXN3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYNPOSynaptopodin. (937 aa)
CSMD2CUB and Sushi multiple domains 2. (3545 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ASIC1Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (526 aa)
NPAS4Neuronal PAS domain protein 4. (802 aa)
NRXN2Neurexin 2. (1613 aa)
Pde8bPhosphodiesterase. (785 aa)
LGMNLegumain. (436 aa)
ABCC8ATP binding cassette subfamily C member 8. (1549 aa)
UBA6Ubiquitin like modifier activating enzyme 6. (1037 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (437 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (350 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (205 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1284 aa)
DCDC2Doublecortin domain containing 2. (469 aa)
RGS14Regulator of G protein signaling 14. (570 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (462 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (888 aa)
TSC1TSC complex subunit 1. (1166 aa)
COMTCatechol-O-methyltransferase. (292 aa)
SYT11Synaptotagmin 11. (431 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (602 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
H0V5P5_CAVPOUncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (385 aa)
PTRHD1Peptidyl-tRNA hydrolase domain containing 1. (140 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1146 aa)
GIT1GIT ArfGAP 1. (757 aa)
GABRB3Gamma-aminobutyric acid type A receptor beta3 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (441 aa)
PPT1Palmitoyl-protein thioesterase 1. (306 aa)
Kmt2aHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (2938 aa)
H0V6I7_CAVPOUncharacterized protein. (231 aa)
ABL1Tyrosine-protein kinase. (1145 aa)
UBE3AUbiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (874 aa)
DEAF1DEAF1 transcription factor. (565 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
NF1Neurofibromin 1. (2750 aa)
CHST10Carbohydrate sulfotransferase. (370 aa)
AMPHAmphiphysin. (680 aa)
NTSNeurotensin. (170 aa)
LRRN4Leucine rich repeat neuronal 4. (772 aa)
CHRDChordin. (892 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (553 aa)
ZZEF1Zinc finger ZZ-type and EF-hand domain containing 1. (2961 aa)
TNRTenascin R. (1358 aa)
TANC1Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1. (1862 aa)
PTNPleiotrophin. (168 aa)
PPP1R1BProtein phosphatase 1 regulatory inhibitor subunit 1B. (184 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
NETO1Neuropilin and tolloid like 1. (450 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1839 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (840 aa)
ABCA7ATP binding cassette subfamily A member 7. (2108 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (559 aa)
VDAC3Voltage dependent anion channel 3. (283 aa)
Atp1a3Sodium/potassium-transporting ATPase subunit alpha. (1028 aa)
EPHB2EPH receptor B2. (949 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
CNTN2Contactin 2. (1041 aa)
PGRMC1Progesterone receptor membrane component 1; Belongs to the cytochrome b5 family. (195 aa)
KALRNKalirin RhoGEF kinase. (2964 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (504 aa)
THTyrosine hydroxylase. (498 aa)
SLC1A1Amino acid transporter. (525 aa)
SLC7A11Solute carrier family 7 member 11. (507 aa)
LOC100730761Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (418 aa)
ABL2Tyrosine-protein kinase. (1157 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1462 aa)
IDUAIduronidase alpha-L-. (644 aa)
EN1Homeobox protein engrailed-like. (292 aa)
SORCS3Sortilin related VPS10 domain containing receptor 3. (1052 aa)
DDHD2DDHD domain containing 2. (668 aa)
CACNA1EVoltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2313 aa)
TACO1Translational activator of cytochrome c oxidase I. (293 aa)
PDE1BPhosphodiesterase. (535 aa)
H0VSR6_CAVPOUncharacterized protein. (327 aa)
GLP1RGlucagon like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (463 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
STRA6Stimulated by retinoic acid 6. (661 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (520 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (229 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1694 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
SRFSerum response factor. (461 aa)
CTNND2Catenin delta 2. (1098 aa)
NPSNeuropeptide S. (72 aa)
GRM7Glutamate metabotropic receptor 7. (922 aa)
H0W1V8_CAVPOUncharacterized protein. (319 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (589 aa)
HRH1Histamine H1 receptor; In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. (482 aa)
TPBGTrophoblast glycoprotein. (426 aa)
H0W426_CAVPOUncharacterized protein; Belongs to the protein kinase superfamily. (416 aa)
DBHDopamine beta-hydroxylase. (616 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ADAM2Disintegrin and metalloproteinase domain-containing protein 2; Sperm surface membrane protein that may be involved in sperm- egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). (731 aa)
CTNSCystinosin, lysosomal cystine transporter. (319 aa)
SHANK1SH3 and multiple ankyrin repeat domains 1. (1749 aa)
AP1S2AP complex subunit sigma; Belongs to the adaptor complexes small subunit family. (160 aa)
ATXN1Ataxin 1. (790 aa)
RIN1Ras and Rab interactor 1. (761 aa)
ARCActivity regulated cytoskeleton associated protein. (395 aa)
MAP1AMicrotubule associated protein 1A. (2915 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
NPTX2Neuronal pentraxin-2; May be involved in binding, concentrating, and sorting soluble glycoproteins or glycolipids that are destined for the acrosome. (417 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
TTC36Tetratricopeptide repeat domain 36. (188 aa)
DRD5Dopamine receptor D5; Belongs to the G-protein coupled receptor 1 family. (474 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
JPH4Junctophilin 4. (627 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (253 aa)
FOXB1Forkhead box B1. (325 aa)
Drd4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (341 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
NTRK2Tyrosine-protein kinase receptor. (816 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
DGKIDiacylglycerol kinase. (957 aa)
SYNJ1Synaptojanin 1. (1607 aa)
CCKCholecystokinin. (115 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (399 aa)
CKAP5Cytoskeleton associated protein 5. (2032 aa)
ADGRB3Adhesion G protein-coupled receptor B3; Belongs to the G-protein coupled receptor 2 family. (1485 aa)
ENSCPOP00000022335Uncharacterized protein. (160 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (210 aa)
NPTNNeuroplastin. (397 aa)
NLGN3Neuroligin 3. (846 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (275 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1217 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1113 aa)
Elavl4ELAV-like protein; Belongs to the RRM elav family. (385 aa)
HTTHuntingtin. (3133 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (926 aa)
DRD1Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
Arf4Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family. (180 aa)
Cln3Battenin. (438 aa)
GRIN1Glutamate ionotropic receptor NMDA type subunit 1. (943 aa)
NRGNNeurogranin. (78 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
CICCapicua transcriptional repressor. (2524 aa)
ENSCPOP00000027747LAM_G_DOMAIN domain-containing protein. (151 aa)
NDRG4NDRG family member 4. (404 aa)
IFT20Intraflagellar transport 20. (132 aa)
NEUROD2Neuronal differentiation 2. (386 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (705 aa)
Vdac1Uncharacterized protein. (283 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (927 aa)
B4GALT2Beta-1,4-galactosyltransferase 2. (369 aa)
Chrna7Uncharacterized protein. (483 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
CRHCorticotropin releasing hormone. (193 aa)
TAFA2TAFA chemokine like family member 2. (89 aa)
Chrnb2Uncharacterized protein. (499 aa)
FOXP2Forkhead box P2. (739 aa)
MAPK8IP2Mitogen-activated protein kinase 8 interacting protein 2. (951 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
SPECC1Sperm antigen with calponin homology and coiled-coil domains 1. (1058 aa)
ENSCPOP00000031438annotation not available (62 aa)
Meis2Meis homeobox 2. (477 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (738 aa)
RELNReelin. (3423 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (801 aa)
ATXN1LAtaxin 1 like. (689 aa)
Cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (361 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
NRXN3Neurexin 3. (1571 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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