43 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTNS	Cystinosin, lysosomal cystine transporter. (319 aa)
	PCDH15	Protocadherin related 15. (1913 aa)
	CNTN2	Contactin 2. (1041 aa)
	Mapt	Microtubule-associated protein. (370 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2996 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
	IDUA	Iduronidase alpha-L-. (644 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (900 aa)
	SCN8A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1876 aa)
	H0W2T6_CAVPO	Uncharacterized protein. (189 aa)
	OXR1	Oxidation resistance 1. (868 aa)
	EFNB3	Ephrin B3; Belongs to the ephrin family. (340 aa)
	Cln8	CLN8 transmembrane ER and ERGIC protein. (288 aa)
	AGTPBP1	ATP/GTP binding protein 1. (1160 aa)
	CACNA1A	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2105 aa)
	Ndufs4	Uncharacterized protein. (175 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2089 aa)
	KLHL5	Kelch like family member 5. (709 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (444 aa)
	Cacnb4	SH3 domain-containing protein. (519 aa)
	KCNJ10	Potassium voltage-gated channel subfamily J member 10. (379 aa)
	EPHA4	EPH receptor A4. (986 aa)
	KLHL1	Kelch like family member 1. (638 aa)
	GBX1	Gastrulation brain homeobox 1. (277 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1133 aa)
	HTRA2	HtrA serine peptidase 2. (455 aa)
	GLRB	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (497 aa)
	CEND1	Cell cycle exit and neuronal differentiation 1. (150 aa)
	UCHL1	Ubiquitin carboxyl-terminal hydrolase. (182 aa)
	SCN1A	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
	ABHD12	Abhydrolase domain containing 12. (397 aa)
	FXN	Frataxin. (211 aa)
	CHAT	Choline O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (621 aa)
	DAB1	DAB adaptor protein 1. (555 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (471 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1277 aa)
	SPTBN4	Spectrin beta chain; Belongs to the spectrin family. (2530 aa)
	DRD2	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	Hexa	Beta-hexosaminidase. (527 aa)
	KLHL4	Kelch like family member 4. (595 aa)
	ARRB2	Arrestin beta 2. (417 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARRB2	DRD1	ENSCPOP00000032723	ENSCPOP00000025180	Arrestin beta 2.	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	0.729
ARRB2	DRD2	ENSCPOP00000032723	ENSCPOP00000008318	Arrestin beta 2.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.946
ATG7	KLHL1	ENSCPOP00000023655	ENSCPOP00000010062	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Kelch like family member 1.	0.428
ATG7	KLHL4	ENSCPOP00000023655	ENSCPOP00000032933	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Kelch like family member 4.	0.428
ATG7	KLHL5	ENSCPOP00000023655	ENSCPOP00000023449	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Kelch like family member 5.	0.428
ATG7	UCHL1	ENSCPOP00000023655	ENSCPOP00000001144	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	Ubiquitin carboxyl-terminal hydrolase.	0.528
CACNA1A	CACNA1C	ENSCPOP00000019798	ENSCPOP00000023058	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.908
CACNA1A	Cacnb4	ENSCPOP00000019798	ENSCPOP00000026155	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	SH3 domain-containing protein.	0.911
CACNA1A	KCNMA1	ENSCPOP00000019798	ENSCPOP00000027309	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	Potassium calcium-activated channel subfamily M alpha 1.	0.558
CACNA1C	CACNA1A	ENSCPOP00000023058	ENSCPOP00000019798	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.908
CACNA1C	Cacnb4	ENSCPOP00000023058	ENSCPOP00000026155	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	SH3 domain-containing protein.	0.911
CACNA1C	EFNB3	ENSCPOP00000023058	ENSCPOP00000017690	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Ephrin B3; Belongs to the ephrin family.	0.430
CACNA1C	KCNMA1	ENSCPOP00000023058	ENSCPOP00000027309	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	Potassium calcium-activated channel subfamily M alpha 1.	0.857
CTNS	IDUA	ENSCPOP00000018157	ENSCPOP00000012425	Cystinosin, lysosomal cystine transporter.	Iduronidase alpha-L-.	0.442
Cacnb4	CACNA1A	ENSCPOP00000026155	ENSCPOP00000019798	SH3 domain-containing protein.	Voltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents.	0.911
Cacnb4	CACNA1C	ENSCPOP00000026155	ENSCPOP00000023058	SH3 domain-containing protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.911
Cacnb4	SCN1A	ENSCPOP00000026155	ENSCPOP00000002422	SH3 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.792
Cacnb4	SCN8A	ENSCPOP00000026155	ENSCPOP00000014115	SH3 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.755
DRD1	ARRB2	ENSCPOP00000025180	ENSCPOP00000032723	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Arrestin beta 2.	0.729
DRD1	DRD2	ENSCPOP00000025180	ENSCPOP00000008318	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family.	Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family.	0.832