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AP3B1 AP3B1 UCHL1 UCHL1 AP3M2 AP3M2 H0UZN0_CAVPO H0UZN0_CAVPO SPG7 SPG7 FMR1 FMR1 DYNC1H1 DYNC1H1 WASF1 WASF1 AP3D1 AP3D1 RAB21 RAB21 AP3M1 AP3M1 HIF1A HIF1A MAPK8IP3 MAPK8IP3 STAU1 STAU1 KIF1B KIF1B KIF5B KIF5B ACTR10 ACTR10 SPAST SPAST DTNBP1 DTNBP1 KIF3A KIF3A AP3B2 AP3B2 HNRNPU HNRNPU CALY CALY NDEL1 NDEL1 KIF5A KIF5A Mapt Mapt MADD MADD AGBL4 AGBL4 SOD1 SOD1 KLC2 KLC2 STAU2 STAU2 FLOT2 FLOT2 KLC3 KLC3 KIF3B KIF3B ARL8A ARL8A TMEM108 TMEM108 KIF17 KIF17 KIF5C KIF5C KLC1 KLC1 AGTPBP1 AGTPBP1 MAP1A MAP1A AP3S2 AP3S2 NEFL NEFL SYBU SYBU APP APP Bloc1s5 Bloc1s5 KIF1C KIF1C Map6 Map6 ARL8B ARL8B PAFAH1B1 PAFAH1B1 AP3S1 AP3S1 BLOC1S2 BLOC1S2 ENSCPOP00000023134 ENSCPOP00000023134 TRAK2 TRAK2 HTT HTT MYO5A MYO5A HDAC6 HDAC6 TRAK1 TRAK1 Nefm Nefm TRIM46 TRIM46 HSBP1 HSBP1 ARMCX3 ARMCX3 SNAPIN SNAPIN BSN BSN BLOC1S6 BLOC1S6 KIF1A KIF1A BLOC1S3 BLOC1S3 FBXW11 FBXW11 TERF2 TERF2 HSPB1 HSPB1 RAB27B RAB27B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AP3B1Adaptor related protein complex 3 subunit beta 1. (1276 aa)
UCHL1Ubiquitin carboxyl-terminal hydrolase. (182 aa)
AP3M2AP-3 complex subunit mu-2. (418 aa)
H0UZN0_CAVPOUncharacterized protein. (763 aa)
SPG7SPG7 matrix AAA peptidase subunit, paraplegin. (802 aa)
FMR1Fragile X mental retardation 1. (612 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4637 aa)
WASF1WASP family member 1. (559 aa)
AP3D1AP-3 complex subunit delta; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. (1161 aa)
RAB21RAB21, member RAS oncogene family. (200 aa)
AP3M1AP-3 complex subunit mu-1; Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes; Belongs to the adaptor complexes medium subunit family. (418 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
MAPK8IP3Mitogen-activated protein kinase 8 interacting protein 3. (1337 aa)
STAU1Staufen double-stranded RNA binding protein 1. (479 aa)
KIF1BKinesin family member 1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1792 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (929 aa)
ACTR10Actin related protein 10; Belongs to the actin family. (416 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
DTNBP1Dystrobrevin binding protein 1. (354 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (728 aa)
AP3B2AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1086 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (822 aa)
CALYCalcyon neuron specific vesicular protein. (220 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (345 aa)
KIF5AKinesin family member 5A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1032 aa)
MaptMicrotubule-associated protein. (370 aa)
MADDMAP kinase activating death domain. (1627 aa)
AGBL4ATP/GTP binding protein like 4. (540 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
KLC2Kinesin light chain 2. (622 aa)
STAU2Staufen double-stranded RNA binding protein 2. (570 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
KLC3Kinesin light chain 3. (503 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (748 aa)
ARL8AADP ribosylation factor like GTPase 8A; Belongs to the small GTPase superfamily. Arf family. (181 aa)
TMEM108Transmembrane protein 108. (566 aa)
KIF17Kinesin family member 17; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1011 aa)
KIF5CKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (957 aa)
KLC1Kinesin light chain 1. (616 aa)
AGTPBP1ATP/GTP binding protein 1. (1160 aa)
MAP1AMicrotubule associated protein 1A. (2915 aa)
AP3S2Adaptor related protein complex 3 subunit sigma 2. (193 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (545 aa)
SYBUUncharacterized protein. (660 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (770 aa)
Bloc1s5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (188 aa)
KIF1CKinesin family member 1C; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1144 aa)
Map6Uncharacterized protein. (522 aa)
ARL8BADP ribosylation factor like GTPase 8B; Belongs to the small GTPase superfamily. Arf family. (186 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
AP3S1Adaptor related protein complex 3 subunit sigma 1. (193 aa)
BLOC1S2Biogenesis of lysosomal organelles complex 1 subunit 2. (142 aa)
ENSCPOP00000023134DRBM domain-containing protein. (120 aa)
TRAK2Trafficking kinesin protein 2. (914 aa)
HTTHuntingtin. (3133 aa)
MYO5AMyosin VA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1877 aa)
HDAC6Histone deacetylase 6. (1196 aa)
TRAK1Trafficking kinesin protein 1. (931 aa)
NefmIF rod domain-containing protein; Belongs to the intermediate filament family. (866 aa)
TRIM46Tripartite motif containing 46. (672 aa)
HSBP1Heat shock factor binding protein 1. (76 aa)
ARMCX3Armadillo repeat containing X-linked 3. (378 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
BSNBassoon presynaptic cytomatrix protein. (3843 aa)
BLOC1S6Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (167 aa)
KIF1AKinesin family member 1A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1791 aa)
BLOC1S3Biogenesis of lysosome-related organelles complex 1 subunit 3; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). Belongs to the BLOC1S3 family. (199 aa)
FBXW11F-box and WD repeat domain containing 11. (530 aa)
TERF2Telomeric repeat binding factor 2. (542 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
RAB27BRAB27B, member RAS oncogene family. (218 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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