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| | MFAP4 | Microfibril associated protein 4. (257 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (486 aa) |
| | Il12a | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (221 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1214 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (214 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (249 aa) |
| | RO60 | Ro60, Y RNA binding protein. (516 aa) |
| | NEDD4 | E3 ubiquitin-protein ligase. (896 aa) |
| | RHBDD1 | Rhomboid domain containing 1. (309 aa) |
| | SIRT1 | Sirtuin 1. (717 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1336 aa) |
| | POLK | DNA polymerase kappa. (540 aa) |
| | PPID | Peptidylprolyl isomerase D. (370 aa) |
| | PML | Promyelocytic leukemia. (849 aa) |
| | ERCC5 | ERCC excision repair 5, endonuclease. (1059 aa) |
| | MEN1 | Menin 1. (615 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (263 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (332 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1051 aa) |
| | ERCC3 | ERCC excision repair 3, TFIIH core complex helicase subunit. (781 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (553 aa) |
| | PRIMPOL | Primase and DNA directed polymerase. (547 aa) |
| | WRN | WRN RecQ like helicase. (1462 aa) |
| | USF1 | Upstream transcription factor 1. (310 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | Ercc8 | WD_REPEATS_REGION domain-containing protein. (396 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3151 aa) |
| | HYAL2 | Hyaluronidase. (471 aa) |
| | EP300 | E1A binding protein p300. (2425 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (559 aa) |
| | TP53I13 | Tumor protein p53 inducible protein 13. (385 aa) |
| | OPN5 | Opsin 5; Belongs to the G-protein coupled receptor 1 family. (333 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1375 aa) |
| | MMP1 | Matrix metallopeptidase 1. (472 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (923 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2539 aa) |
| | Pold3 | Uncharacterized protein. (466 aa) |
| | EI24 | EI24 autophagy associated transmembrane protein. (349 aa) |
| | MMP9 | Matrix metallopeptidase 9. (715 aa) |
| | DHX36 | DEAH-box helicase 36. (916 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | MME | Membrane metalloendopeptidase. (718 aa) |
| | BRSK1 | BR serine/threonine kinase 1. (763 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | OPN1SW | G_PROTEIN_RECEP_F1_2 domain-containing protein. (346 aa) |
| | H0VGS2_CAVPO | Uncharacterized protein. (611 aa) |
| | PBK | PDZ binding kinase. (324 aa) |
| | CCAR2 | Cell cycle and apoptosis regulator 2. (924 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1455 aa) |
| | C10orf90 | Chromosome 10 open reading frame 90. (700 aa) |
| | INO80 | INO80 complex ATPase subunit. (1558 aa) |
| | Aqp1 | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (602 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1251 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (447 aa) |
| | CAT | Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells; Belongs to the catalase family. (527 aa) |
| | MAP4K3 | Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa) |
| | DDIAS | DNA damage induced apoptosis suppressor. (897 aa) |
| | TIMP1 | TIMP metallopeptidase inhibitor 1. (207 aa) |
| | FECH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (424 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (289 aa) |
| | MAP3K4 | Mitogen-activated protein kinase kinase kinase 4. (1601 aa) |
| | TMEM161A | Transmembrane protein 161A. (474 aa) |
| | UVSSA | UV stimulated scaffold protein A. (730 aa) |
| | RAD18 | RAD18 E3 ubiquitin protein ligase. (493 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (901 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (366 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (453 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (734 aa) |
| | Parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | SPRTN | SprT-like N-terminal domain. (481 aa) |
| | BCL3 | BCL3 transcription coactivator. (424 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | Chek1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (439 aa) |
| | CIRBP | Cold inducible RNA binding protein. (173 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (764 aa) |
| | MAP2K7 | Mitogen-activated protein kinase kinase 7. (459 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (549 aa) |
| | BCL2 | BCL2 apoptosis regulator. (183 aa) |
| | Yy1 | Uncharacterized protein. (195 aa) |
| | N4BP1 | NEDD4 binding protein 1. (886 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (233 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (760 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa) |
| | ENSCPOP00000025455 | Protein kinase domain-containing protein. (360 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (936 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (169 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit alpha. (315 aa) |
| | ENSCPOP00000027080 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (143 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | POLH | DNA polymerase eta. (712 aa) |
| | Crip1 | LIM zinc-binding domain-containing protein. (77 aa) |
| | MC1R | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (316 aa) |
| | HMGN1 | High mobility group nucleosome binding domain 1. (130 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | SDF4 | Stromal cell derived factor 4. (378 aa) |
| | MAPK9 | Mitogen-activated protein kinase. (424 aa) |
| | UBE2B | Ubiquitin conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | Gdf1 | TGF_BETA_2 domain-containing protein. (367 aa) |
| | BRSK2 | BR serine/threonine kinase 2. (718 aa) |
| | ENSCPOP00000024428 | PARP-type domain-containing protein. (104 aa) |
| | ENSCPOP00000029395 | DCN1-like protein. (251 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa) |
| | BMF | Bcl2 modifying factor. (236 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (865 aa) |
| | POLI | DNA polymerase iota. (662 aa) |
| | ERCC1 | ERCC excision repair 1, endonuclease non-catalytic subunit. (300 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1473 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | CREBBP | CREB binding protein. (2441 aa) |
| | TRIAP1 | TP53 regulated inhibitor of apoptosis 1. (76 aa) |
| | Pclaf | PAF domain-containing protein. (112 aa) |
| | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1418 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (799 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | IMPACT | Impact RWD domain protein. (318 aa) |
| | Pmaip1 | Uncharacterized protein. (102 aa) |
| | Cops9 | Uncharacterized protein. (57 aa) |
| | C9orf116 | Chromosome 9 open reading frame 116. (136 aa) |
| | Ube2a | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (326 aa) |
| | OPN3 | Opsin 3; Belongs to the G-protein coupled receptor 1 family. (399 aa) |
| | Dcun1d3 | DCN1-like protein. (304 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (712 aa) |
| | UBE4B | Ubiquitination factor E4B. (1347 aa) |
| | MMP3 | Matrix metallopeptidase 3. (479 aa) |
| | Bivm | Uncharacterized protein. (503 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (240 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (491 aa) |
| | POLD1 | DNA polymerase. (1134 aa) |
| | HYAL3 | Hyaluronidase. (412 aa) |
| | MMP2 | Matrix metallopeptidase 2. (662 aa) |
