STRINGSTRING
ROM1 ROM1 ARRB2 ARRB2 ENSCPOP00000032677 ENSCPOP00000032677 TCAP TCAP PCDH15 PCDH15 JUP JUP PIEZO1 PIEZO1 CAV3 CAV3 ENSCPOP00000030659 ENSCPOP00000030659 PTPRQ PTPRQ ENSCPOP00000028869 ENSCPOP00000028869 CABP4 CABP4 MKKS MKKS ANO1 ANO1 Tac4 Tac4 CXCR4 CXCR4 ENSCPOP00000027148 ENSCPOP00000027148 AIPL1 AIPL1 ENSCPOP00000026472 ENSCPOP00000026472 Cacnb4 Cacnb4 FYN FYN MYC MYC SERPINE2 SERPINE2 ARRB1 ARRB1 ENSCPOP00000024842 ENSCPOP00000024842 RCVRN RCVRN PHF24 PHF24 CSRP3 CSRP3 ENSCPOP00000024015 ENSCPOP00000024015 ENSCPOP00000023932 ENSCPOP00000023932 OPN3 OPN3 ASIC3 ASIC3 CXCL12 CXCL12 PJVK PJVK ASIC2 ASIC2 PCP2 PCP2 PRPH2 PRPH2 CHRNA10 CHRNA10 H0WA79_CAVPO H0WA79_CAVPO KCNK4 KCNK4 PKDREJ PKDREJ H0W5R9_CAVPO H0W5R9_CAVPO LOC100726021 LOC100726021 CACNA1F CACNA1F GJA10 GJA10 RGR RGR SEMA5B SEMA5B LHFPL5 LHFPL5 ATP2B2 ATP2B2 REEP6 REEP6 PDE6B PDE6B HPN HPN RGS9BP RGS9BP OTOP1 OTOP1 KCNQ1 KCNQ1 ITGA2 ITGA2 Guca1a Guca1a TMC2 TMC2 TLR4 TLR4 PKD2 PKD2 SLC12A2 SLC12A2 H0VQQ2_CAVPO H0VQQ2_CAVPO H0VQ66_CAVPO H0VQ66_CAVPO RPE65 RPE65 IRX6 IRX6 PIEZO2 PIEZO2 PKD2L2 PKD2L2 FECH FECH COL11A1 COL11A1 CHRNA5 CHRNA5 Trpa1 Trpa1 Gnat2 Gnat2 KIT KIT Opn1mw Opn1mw PKD2L1 PKD2L1 SLC24A4 SLC24A4 OPN1SW OPN1SW TRPV1 TRPV1 H0VFY3_CAVPO H0VFY3_CAVPO GUCA1B GUCA1B CCDC66 CCDC66 GNGT1 GNGT1 CHRNA9 CHRNA9 GNAT1 GNAT1 RS1 RS1 SEMA5A SEMA5A GUCY2F GUCY2F TMEM120A TMEM120A BEST1 BEST1 GRIN2B GRIN2B PRDM12 PRDM12 OPN5 OPN5 ANO3 ANO3 Trpm8 Trpm8 CACNA2D4 CACNA2D4 RHO RHO KCNA1 KCNA1 PDE6C PDE6C RRH RRH MMP24 MMP24 H0V266_CAVPO H0V266_CAVPO CACNB3 CACNB3 PKD1 PKD1 NTRK1 NTRK1 IL18 IL18 TMC1 TMC1 Rdh11 Rdh11 SCN1A SCN1A PAWR PAWR RBP4 RBP4 EPHB1 EPHB1 GRIK2 GRIK2 LXN LXN OPN4 OPN4 NOX3 NOX3 Pdzd7 Pdzd7 WHRN WHRN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROM1Retinal outer segment membrane protein 1. (351 aa)
ARRB2Arrestin beta 2. (417 aa)
ENSCPOP00000032677Eph LBD domain-containing protein. (286 aa)
TCAPTitin-cap. (167 aa)
PCDH15Protocadherin related 15. (1913 aa)
JUPJunction plakoglobin. (745 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2499 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
ENSCPOP00000030659G_PROTEIN_RECEP_F3_4 domain-containing protein. (497 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2192 aa)
ENSCPOP00000028869Uncharacterized protein. (609 aa)
CABP4Calcium binding protein 4. (271 aa)
MKKSMcKusick-Kaufman syndrome. (575 aa)
ANO1Anoctamin. (1011 aa)
Tac4Uncharacterized protein. (90 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (346 aa)
ENSCPOP00000027148Uncharacterized protein. (278 aa)
AIPL1Aryl hydrocarbon receptor interacting protein like 1. (328 aa)
ENSCPOP00000026472Uncharacterized protein. (286 aa)
Cacnb4SH3 domain-containing protein. (519 aa)
FYNTyrosine-protein kinase. (537 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (438 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (397 aa)
ARRB1Arrestin beta 1. (430 aa)
ENSCPOP00000024842Uncharacterized protein. (173 aa)
RCVRNRecoverin. (202 aa)
PHF24PHD finger protein 24. (400 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
ENSCPOP00000024015Uncharacterized protein. (5460 aa)
ENSCPOP00000023932Uncharacterized protein. (332 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (532 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
PJVKPejvakin. (352 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (493 aa)
PCP2Purkinje cell protein 2. (119 aa)
PRPH2Peripherin 2. (346 aa)
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (447 aa)
H0WA79_CAVPOANF_receptor domain-containing protein. (187 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (392 aa)
PKDREJPolycystin family receptor for egg jelly. (2029 aa)
H0W5R9_CAVPOUncharacterized protein. (1527 aa)
LOC100726021Uncharacterized protein. (1725 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1774 aa)
GJA10Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (438 aa)
RGRRetinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (282 aa)
SEMA5BSemaphorin 5B. (1053 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (219 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1296 aa)
REEP6Receptor expression-enhancing protein. (202 aa)
PDE6BPhosphodiesterase. (854 aa)
HPNHepsin; Belongs to the peptidase S1 family. (433 aa)
RGS9BPRegulator of G protein signaling 9 binding protein. (235 aa)
OTOP1Otopetrin 1. (578 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (671 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1156 aa)
Guca1aUncharacterized protein. (200 aa)
TMC2Transmembrane channel-like protein. (868 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (837 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (839 aa)
SLC12A2Solute carrier family 12 member 2. (1136 aa)
H0VQQ2_CAVPOCyclic nucleotide-binding domain-containing protein. (852 aa)
H0VQ66_CAVPOUncharacterized protein. (336 aa)
RPE65Retinoid isomerohydrolase RPE65. (490 aa)
IRX6Iroquois homeobox 6. (445 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2744 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (621 aa)
FECHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (424 aa)
COL11A1Collagen type XI alpha 1 chain. (1712 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (438 aa)
Trpa1ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (991 aa)
Gnat2Uncharacterized protein. (354 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
Opn1mwMedium-wave-sensitive opsin 1; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. May increase spectral sensitivity in dim light; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (386 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (760 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (605 aa)
OPN1SWG_PROTEIN_RECEP_F1_2 domain-containing protein. (346 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits [...] (839 aa)
H0VFY3_CAVPOUncharacterized protein. (674 aa)
GUCA1BGuanylate cyclase activator 1B. (200 aa)
CCDC66Coiled-coil domain containing 66. (932 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (465 aa)
GNAT1Alpha-transducin. (350 aa)
RS1Retinoschisin 1. (224 aa)
SEMA5ASemaphorin 5A. (1073 aa)
GUCY2FGuanylate cyclase. (1109 aa)
TMEM120ATransmembrane protein 120A. (343 aa)
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (566 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1381 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (329 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (333 aa)
ANO3Anoctamin. (981 aa)
Trpm8Transient potential cation channel subfamily M member 8. (1104 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1101 aa)
RHORhodopsin. (348 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
PDE6CPhosphodiesterase. (862 aa)
RRHRetinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (337 aa)
MMP24Matrix metallopeptidase 24. (573 aa)
H0V266_CAVPOUncharacterized protein. (2204 aa)
CACNB3Calcium voltage-gated channel auxiliary subunit beta 3. (484 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4283 aa)
NTRK1Tyrosine-protein kinase receptor. (798 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (189 aa)
TMC1Transmembrane channel-like protein. (761 aa)
Rdh11Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (316 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1997 aa)
PAWRPro-apoptotic WT1 regulator. (307 aa)
RBP4Apolipoprotein D. (173 aa)
EPHB1EPH receptor B1. (736 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
LXNLatexin. (222 aa)
OPN4Opsin 4. (471 aa)
NOX3NADPH oxidase 3. (568 aa)
Pdzd7Uncharacterized protein. (553 aa)
WHRNWhirlin. (916 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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