STRINGSTRING
KAT8 KAT8 IL10 IL10 KEAP1 KEAP1 SH3GLB1 SH3GLB1 SNX7 SNX7 EPM2A EPM2A DCN DCN ATP13A2 ATP13A2 LZTS1 LZTS1 SVIP SVIP NOD2 NOD2 LOC100715212 LOC100715212 MTM1 MTM1 RAB8A RAB8A DAPL1 DAPL1 RPTOR RPTOR BECN1 BECN1 MCL1 MCL1 Il4 Il4 CLEC16A CLEC16A ADRA1A ADRA1A Wdr45 Wdr45 CISD2 CISD2 BCL2L11 BCL2L11 STING1 STING1 BMF BMF HSPB8 HSPB8 LOC101788042 LOC101788042 KIAA1324 KIAA1324 TP53 TP53 BNIP3 BNIP3 ENSCPOP00000029603 ENSCPOP00000029603 EIF4G2 EIF4G2 LEP LEP ENSCPOP00000029147 ENSCPOP00000029147 ACER2 ACER2 ATG13 ATG13 AMBRA1 AMBRA1 Cisd1 Cisd1 TRIM32 TRIM32 Vdac1 Vdac1 TMEM59 TMEM59 SNX18 SNX18 ULK1 ULK1 RNF152 RNF152 ATG16L1 ATG16L1 LOC100729512 LOC100729512 ENSCPOP00000027535 ENSCPOP00000027535 LRSAM1 LRSAM1 CPTP CPTP LOC100715128 LOC100715128 SEC22B SEC22B TRIM6 TRIM6 MFSD8 MFSD8 SCOC SCOC FBXW7 FBXW7 IL10RA IL10RA SNCA SNCA TFEB TFEB Cln3 Cln3 AKT1 AKT1 FOXK2 FOXK2 HDAC6 HDAC6 STK11 STK11 CHMP4B CHMP4B LOC100724130 LOC100724130 WAC WAC STAT3 STAT3 FEZ2 FEZ2 LOC100714297 LOC100714297 MAP3K7 MAP3K7 RALB RALB TSPO TSPO NPRL3 NPRL3 LOC100714922 LOC100714922 Dap Dap Washc1 Washc1 BOK BOK Gdf1 Gdf1 NOD1 NOD1 HTT HTT NUPR1 NUPR1 Dram1 Dram1 PLEKHF1 PLEKHF1 ENSCPOP00000023749 ENSCPOP00000023749 ATG7 ATG7 TP53INP2 TP53INP2 PYCARD PYCARD ORMDL3 ORMDL3 SIRT2 SIRT2 TECPR1 TECPR1 BNIP3L BNIP3L LOC100714924 LOC100714924 Pafah1b2 Pafah1b2 MTMR9 MTMR9 TP53INP1 TP53INP1 RAB39B RAB39B RNF5 RNF5 MT3 MT3 KAT5 KAT5 SUPT5H SUPT5H RNF41 RNF41 RAB3GAP1 RAB3GAP1 MTCL1 MTCL1 ATG12 ATG12 PHF23 PHF23 TMEM39A TMEM39A IKBKG IKBKG TLR2 TLR2 HMOX1 HMOX1 GSK3A GSK3A ENDOG ENDOG GFAP GFAP WDR6 WDR6 SH3BP4 SH3BP4 DCAF12L2 DCAF12L2 RAB12 RAB12 ADRB2 ADRB2 H0W5F0_CAVPO H0W5F0_CAVPO Foxo3 Foxo3 CALCOCO2 CALCOCO2 BCL2 BCL2 SESN3 SESN3 RB1CC1 RB1CC1 Rnf31 Rnf31 H0W027_CAVPO H0W027_CAVPO LOC100721657 LOC100721657 PLK2 PLK2 H0VXJ2_CAVPO H0VXJ2_CAVPO TRIM13 TRIM13 LOC100727489 LOC100727489 GPSM1 GPSM1 RRAGA RRAGA LOC100728392 LOC100728392 PIP4K2C PIP4K2C KLHL22 KLHL22 KIAA0408 KIAA0408 PINK1 PINK1 ATG101 ATG101 WDR24 WDR24 DNM1L DNM1L Lamp3 Lamp3 TRIM65 TRIM65 SPTLC1 SPTLC1 LEPR LEPR EHMT2 EHMT2 FBXO7 FBXO7 WIPI1 WIPI1 GSK3B GSK3B FOXK1 FOXK1 ATG5 ATG5 Parl Parl FBXL2 FBXL2 SESN1 SESN1 UBQLN2 UBQLN2 MAPK15 MAPK15 SMO SMO Mapt Mapt USP30 USP30 LOC100728497 LOC100728497 DDIT3 DDIT3 CTSA CTSA GPR137B GPR137B SMG1 SMG1 USP10 USP10 Nrbp2 Nrbp2 FLCN FLCN TRIM8 TRIM8 TRIM27 TRIM27 TRIM21 TRIM21 SNX30 SNX30 MTOR MTOR ZMPSTE24 ZMPSTE24 GNAI3 GNAI3 SOGA1 SOGA1 ATP6V0A1 ATP6V0A1 RRAGB RRAGB ZC3H12A ZC3H12A IFNG IFNG ATM ATM TBK1 TBK1 TRIML1 TRIML1 ROCK1 ROCK1 USP36 USP36 VPS13D VPS13D Kdm4a Kdm4a ATF6 ATF6 UVRAG UVRAG ULK2 ULK2 KDR KDR PRKAA2 PRKAA2 Mefv Mefv TIGAR TIGAR H0VF19_CAVPO H0VF19_CAVPO C9orf72 C9orf72 SMCR8 SMCR8 SNX4 SNX4 NAMPT NAMPT SLC25A5 SLC25A5 H0VCZ7_CAVPO H0VCZ7_CAVPO ATG2A ATG2A RAB3GAP2 RAB3GAP2 FYCO1 FYCO1 XBP1 XBP1 RRAGC RRAGC OPTN OPTN PIP4K2A PIP4K2A BAG3 BAG3 PIK3R4 PIK3R4 H0V9V8_CAVPO H0V9V8_CAVPO EIF4G1 EIF4G1 SCFD1 SCFD1 FBXW9 FBXW9 UFL1 UFL1 SLC7A5 SLC7A5 TMEM39B TMEM39B RIPK2 RIPK2 DEPP1 DEPP1 NPC1 NPC1 RMC1 RMC1 PIM2 PIM2 Gata4 Gata4 Depdc5 Depdc5 HERC1 HERC1 TRIB3 TRIB3 CTTN CTTN CDK16 CDK16 PIP4K2B PIP4K2B TPCN1 TPCN1 PRKAA1 PRKAA1 HIF1A HIF1A SLC25A4 SLC25A4 PRKD1 PRKD1 ERCC4 ERCC4 TSC1 TSC1 PIK3C3 PIK3C3 RRAGD RRAGD TREM2 TREM2 USP33 USP33 TBC1D25 TBC1D25 DRAM2 DRAM2 MTMR4 MTMR4 H0V0S2_CAVPO H0V0S2_CAVPO LARP1 LARP1 TSC2 TSC2 FEZ1 FEZ1 POLDIP2 POLDIP2 MAP2K1 MAP2K1 CRYBA1 CRYBA1 NPRL2 NPRL2 TPCN2 TPCN2 UBQLN4 UBQLN4 MTMR3 MTMR3 SREBF1 SREBF1 USP13 USP13 QSOX1 QSOX1 PLK3 PLK3 RUBCN RUBCN RASIP1 RASIP1 HPSE HPSE XPA XPA SPTLC2 SPTLC2 DCAF12 DCAF12 WDR41 WDR41 ATG14 ATG14 DAPK1 DAPK1 PTK2 PTK2 SIRT1 SIRT1 TRIML2 TRIML2 AGER AGER HTR2B HTR2B SESN2 SESN2 VPS13C VPS13C PIK3C2A PIK3C2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (178 aa)
KEAP1Kelch like ECH associated protein 1. (411 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
SNX7Sorting nexin 7. (470 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1173 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
SVIPSmall VCP interacting protein. (77 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1018 aa)
LOC100715212Uncharacterized protein. (482 aa)
MTM1Myotubularin 1. (599 aa)
RAB8ARAB8A, member RAS oncogene family. (207 aa)
DAPL1Death associated protein like 1. (107 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1335 aa)
BECN1Beclin 1. (448 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (233 aa)
Il4Interleukin-4. (144 aa)
CLEC16AC-type lectin domain containing 16A. (1049 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
Wdr45Uncharacterized protein. (360 aa)
CISD2CDGSH iron sulfur domain 2. (135 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
STING1Transmembrane protein 173. (379 aa)
BMFBcl2 modifying factor. (236 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
LOC101788042C2 domain-containing protein. (110 aa)
KIAA1324KIAA1324. (1014 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (423 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
ENSCPOP00000029603Uncharacterized protein. (144 aa)
EIF4G2Eukaryotic translation initiation factor 4 gamma 2. (957 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (165 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
Cisd1annotation not available (108 aa)
TRIM32Tripartite motif containing 32. (653 aa)
Vdac1Uncharacterized protein. (283 aa)
TMEM59Transmembrane protein 59. (323 aa)
SNX18Sorting nexin. (607 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
RNF152Ring finger protein 152. (203 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
LOC100729512IRG-type G domain-containing protein. (418 aa)
ENSCPOP00000027535Uncharacterized protein. (148 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (727 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
LOC100715128Uncharacterized protein. (474 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein (gene/pseudogene); Belongs to the synaptobrevin family. (215 aa)
TRIM6Tripartite motif containing 6. (488 aa)
MFSD8Major facilitator superfamily domain containing 8. (521 aa)
SCOCShort coiled-coil protein. (82 aa)
FBXW7F-box and WD repeat domain containing 7. (711 aa)
IL10RAInterleukin 10 receptor subunit alpha. (583 aa)
SNCAAlpha-synuclein; Belongs to the synuclein family. (140 aa)
TFEBTranscription factor EB. (468 aa)
Cln3Battenin. (438 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FOXK2Forkhead box K2. (614 aa)
HDAC6Histone deacetylase 6. (1196 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
CHMP4BCharged multivesicular body protein 4B. (224 aa)
LOC100724130TIR domain-containing protein. (1029 aa)
WACWW domain containing adaptor with coiled-coil. (632 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
FEZ2Fasciculation and elongation protein zeta 2. (318 aa)
LOC100714297Uncharacterized protein. (464 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RALBRAS like proto-oncogene B. (206 aa)
TSPOTranslocator protein. (169 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
DapUncharacterized protein. (102 aa)
Washc1WH2 domain-containing protein. (472 aa)
BOKBCL2 family apoptosis regulator BOK. (179 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (873 aa)
HTTHuntingtin. (3133 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (90 aa)
Dram1Uncharacterized protein. (446 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (278 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (222 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (352 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1166 aa)
BNIP3LBCL2 interacting protein 3 like. (214 aa)
LOC100714924Uncharacterized protein. (288 aa)
Pafah1b2SGNH_hydro domain-containing protein. (202 aa)
MTMR9Myotubularin related protein 9. (549 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
RAB39BRAB39B, member RAS oncogene family. (213 aa)
RNF5Ring finger protein 5. (180 aa)
MT3Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (66 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
RNF41Ring finger protein 41. (317 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
MTCL1Microtubule crosslinking factor 1. (1642 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
PHF23PHD finger protein 23. (350 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
HMOX1Heme oxygenase 1. (297 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
ENDOGEndonuclease. (299 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (431 aa)
WDR6WD repeat domain 6. (1121 aa)
SH3BP4SH3 domain binding protein 4. (964 aa)
DCAF12L2DDB1 and CUL4 associated factor 12 like 2. (394 aa)
RAB12RAB12, member RAS oncogene family. (210 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
H0W5F0_CAVPOBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
Foxo3Forkhead box O3. (660 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (443 aa)
BCL2BCL2 apoptosis regulator. (183 aa)
SESN3Sestrin 3. (414 aa)
RB1CC1RB1 inducible coiled-coil 1. (1431 aa)
Rnf31Uncharacterized protein. (1072 aa)
H0W027_CAVPOUncharacterized protein. (722 aa)
LOC100721657Uncharacterized protein. (854 aa)
PLK2Serine/threonine-protein kinase PLK. (682 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
TRIM13Tripartite motif containing 13. (407 aa)
LOC100727489Uncharacterized protein. (534 aa)
GPSM1G protein signaling modulator 1. (706 aa)
RRAGARas related GTP binding A. (313 aa)
LOC100728392Interferon-gamma-inducible GTPase IFGGD1 protein. (398 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (419 aa)
KLHL22Kelch like family member 22. (639 aa)
KIAA0408KIAA0408. (691 aa)
PINK1PTEN induced kinase 1. (574 aa)
ATG101Autophagy related 101. (218 aa)
WDR24WD repeat domain 24. (790 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
Lamp3Uncharacterized protein. (418 aa)
TRIM65Tripartite motif containing 65. (515 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
LEPRLeptin receptor. (1174 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1188 aa)
FBXO7F-box protein 7. (524 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
FOXK1Forkhead box K1. (638 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ParlRhomboid domain-containing protein. (379 aa)
FBXL2F-box and leucine rich repeat protein 2. (430 aa)
SESN1Sestrin 1. (564 aa)
UBQLN2Ubiquilin 2. (624 aa)
MAPK15Mitogen-activated protein kinase. (539 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
MaptMicrotubule-associated protein. (370 aa)
USP30Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (517 aa)
LOC100728497ZnF_CDGSH domain-containing protein. (108 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (475 aa)
GPR137BG protein-coupled receptor 137B. (385 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3632 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (780 aa)
Nrbp2Uncharacterized protein. (258 aa)
FLCNFolliculin. (579 aa)
TRIM8Tripartite motif containing 8. (460 aa)
TRIM27Tripartite motif containing 27. (504 aa)
TRIM21Tripartite motif containing 21. (467 aa)
SNX30Sorting nexin family member 30. (493 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
SOGA1Suppressor of glucose, autophagy associated 1. (1430 aa)
ATP6V0A1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (832 aa)
RRAGBRas related GTP binding B. (362 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (550 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3031 aa)
TBK1TANK binding kinase 1. (729 aa)
TRIML1Tripartite motif family like 1. (474 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
USP36Ubiquitin specific peptidase 36; Belongs to the peptidase C19 family. (1102 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4228 aa)
Kdm4aUncharacterized protein. (978 aa)
ATF6Activating transcription factor 6. (659 aa)
UVRAGUV radiation resistance associated. (698 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1033 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MefvUncharacterized protein. (618 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
H0VF19_CAVPOUncharacterized protein. (99 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
SNX4Sorting nexin 4. (403 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (487 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
ATG2AAutophagy related 2A. (1904 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1314 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1440 aa)
XBP1X-box binding protein 1. (268 aa)
RRAGCRas related GTP binding C. (399 aa)
OPTNOptineurin. (576 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (398 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1354 aa)
H0V9V8_CAVPOWH2 domain-containing protein. (298 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1579 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (664 aa)
FBXW9F-box and WD repeat domain containing 9. (457 aa)
UFL1UFM1 specific ligase 1. (762 aa)
SLC7A5Solute carrier family 7 member 5. (477 aa)
TMEM39BTransmembrane protein 39B. (495 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
DEPP1DEPP1 autophagy regulator. (187 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
RMC1Regulator of MON1-CCZ1. (657 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
Gata4Uncharacterized protein. (237 aa)
Depdc5DEP domain-containing protein. (1576 aa)
HERC1HECT and RLD domain containing E3 ubiquitin protein ligase family member 1. (4568 aa)
TRIB3Tribbles pseudokinase 3. (308 aa)
CTTNCortactin. (550 aa)
CDK16Cyclin dependent kinase 16; Belongs to the protein kinase superfamily. (496 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (362 aa)
TPCN1Two pore channel 1. (817 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
TSC1TSC complex subunit 1. (1166 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
RRAGDRas related GTP binding D. (348 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (229 aa)
USP33Ubiquitinyl hydrolase 1. (850 aa)
TBC1D25TBC1 domain family member 25. (716 aa)
DRAM2DNA damage regulated autophagy modulator 2. (265 aa)
MTMR4Myotubularin related protein 4. (1189 aa)
H0V0S2_CAVPOB box-type domain-containing protein. (274 aa)
LARP1La ribonucleoprotein domain family member 1. (954 aa)
TSC2TSC complex subunit 2. (1745 aa)
FEZ1Fasciculation and elongation protein zeta 1. (403 aa)
POLDIP2DNA polymerase delta interacting protein 2. (368 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
CRYBA1Beta A3-crystallin; Belongs to the beta/gamma-crystallin family. (215 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
TPCN2Two pore channel 2. (752 aa)
UBQLN4Ubiquilin 4. (593 aa)
MTMR3Myotubularin related protein 3. (1221 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1155 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (823 aa)
QSOX1Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration. (613 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
RUBCNRubicon autophagy regulator. (954 aa)
RASIP1Ras interacting protein 1. (963 aa)
HPSEHeparanase. (526 aa)
XPAXPA, DNA damage recognition and repair factor. (263 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
DCAF12DDB1 and CUL4 associated factor 12. (371 aa)
WDR41WD repeat domain 41. (462 aa)
ATG14Autophagy related 14. (492 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
SIRT1Sirtuin 1. (717 aa)
TRIML2Tripartite motif family like 2. (431 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (480 aa)
SESN2Sestrin 2. (480 aa)
VPS13CVacuolar protein sorting 13 homolog C. (2875 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1404 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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