STRINGSTRING
GSK3A GSK3A SH3GLB1 SH3GLB1 SNX7 SNX7 EPM2A EPM2A DCN DCN SVIP SVIP NOD2 NOD2 LOC100715212 LOC100715212 BECN1 BECN1 Il4 Il4 CLEC16A CLEC16A Wdr45 Wdr45 BCL2L11 BCL2L11 STING1 STING1 HSPB8 HSPB8 LOC101788042 LOC101788042 KIAA1324 KIAA1324 BNIP3 BNIP3 ENSCPOP00000029147 ENSCPOP00000029147 ATG13 ATG13 AMBRA1 AMBRA1 TRIM32 TRIM32 Vdac1 Vdac1 TMEM59 TMEM59 SNX18 SNX18 ULK1 ULK1 RNF152 RNF152 ATG16L1 ATG16L1 LOC100729512 LOC100729512 ENSCPOP00000027535 ENSCPOP00000027535 LRSAM1 LRSAM1 LOC100715128 LOC100715128 TRIM6 TRIM6 SCOC SCOC TFEB TFEB STK11 STK11 LOC100724130 LOC100724130 WAC WAC LOC100714297 LOC100714297 MAP3K7 MAP3K7 RALB RALB NPRL3 NPRL3 LOC100714922 LOC100714922 Gdf1 Gdf1 NOD1 NOD1 HTT HTT PLEKHF1 PLEKHF1 ENSCPOP00000023749 ENSCPOP00000023749 ATG7 ATG7 TP53INP2 TP53INP2 ORMDL3 ORMDL3 BNIP3L BNIP3L LOC100714924 LOC100714924 Pafah1b2 Pafah1b2 TP53INP1 TP53INP1 KAT5 KAT5 SUPT5H SUPT5H RAB3GAP1 RAB3GAP1 IKBKG IKBKG TLR2 TLR2 HMOX1 HMOX1 ENDOG ENDOG SH3BP4 SH3BP4 RAB12 RAB12 ADRB2 ADRB2 H0W5F0_CAVPO H0W5F0_CAVPO Foxo3 Foxo3 CALCOCO2 CALCOCO2 SESN3 SESN3 RB1CC1 RB1CC1 Rnf31 Rnf31 PLK2 PLK2 H0VXJ2_CAVPO H0VXJ2_CAVPO TRIM13 TRIM13 LOC100727489 LOC100727489 GPSM1 GPSM1 LOC100728392 LOC100728392 PIP4K2C PIP4K2C PINK1 PINK1 ATG101 ATG101 WDR24 WDR24 TRIM65 TRIM65 SPTLC1 SPTLC1 FBXO7 FBXO7 WIPI1 WIPI1 GSK3B GSK3B SESN1 SESN1 SMO SMO DDIT3 DDIT3 FLCN FLCN TRIM8 TRIM8 TRIM27 TRIM27 TRIM21 TRIM21 SNX30 SNX30 GNAI3 GNAI3 ZC3H12A ZC3H12A IFNG IFNG TBK1 TBK1 TRIML1 TRIML1 ROCK1 ROCK1 VPS13D VPS13D ATF6 ATF6 ULK2 ULK2 KDR KDR PRKAA2 PRKAA2 Mefv Mefv C9orf72 C9orf72 SMCR8 SMCR8 SNX4 SNX4 SLC25A5 SLC25A5 H0VCZ7_CAVPO H0VCZ7_CAVPO ATG2A ATG2A RAB3GAP2 RAB3GAP2 FYCO1 FYCO1 OPTN OPTN PIP4K2A PIP4K2A BAG3 BAG3 UFL1 UFL1 RIPK2 RIPK2 PIM2 PIM2 Depdc5 Depdc5 CDK16 CDK16 PIP4K2B PIP4K2B TPCN1 TPCN1 PRKAA1 PRKAA1 HIF1A HIF1A SLC25A4 SLC25A4 PRKD1 PRKD1 TSC1 TSC1 H0V0S2_CAVPO H0V0S2_CAVPO LARP1 LARP1 TSC2 TSC2 MAP2K1 MAP2K1 NPRL2 NPRL2 PLK3 PLK3 HPSE HPSE SPTLC2 SPTLC2 DAPK1 DAPK1 SIRT1 SIRT1 TRIML2 TRIML2 AGER AGER SESN2 SESN2 PIK3C2A PIK3C2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (394 aa)
SNX7Sorting nexin 7. (470 aa)
EPM2AEPM2A glucan phosphatase, laforin. (193 aa)
DCNDecorin; May affect the rate of fibrils formation. (361 aa)
SVIPSmall VCP interacting protein. (77 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1018 aa)
LOC100715212Uncharacterized protein. (482 aa)
BECN1Beclin 1. (448 aa)
Il4Interleukin-4. (144 aa)
CLEC16AC-type lectin domain containing 16A. (1049 aa)
Wdr45Uncharacterized protein. (360 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
STING1Transmembrane protein 173. (379 aa)
HSPB8Heat shock protein family B (small) member 8; Belongs to the small heat shock protein (HSP20) family. (196 aa)
LOC101788042C2 domain-containing protein. (110 aa)
KIAA1324KIAA1324. (1014 aa)
BNIP3BCL2 interacting protein 3. (194 aa)
ENSCPOP00000029147Uncharacterized protein. (272 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1291 aa)
TRIM32Tripartite motif containing 32. (653 aa)
Vdac1Uncharacterized protein. (283 aa)
TMEM59Transmembrane protein 59. (323 aa)
SNX18Sorting nexin. (607 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1037 aa)
RNF152Ring finger protein 152. (203 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
LOC100729512IRG-type G domain-containing protein. (418 aa)
ENSCPOP00000027535Uncharacterized protein. (148 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (727 aa)
LOC100715128Uncharacterized protein. (474 aa)
TRIM6Tripartite motif containing 6. (488 aa)
SCOCShort coiled-coil protein. (82 aa)
TFEBTranscription factor EB. (468 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (435 aa)
LOC100724130TIR domain-containing protein. (1029 aa)
WACWW domain containing adaptor with coiled-coil. (632 aa)
LOC100714297Uncharacterized protein. (464 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
RALBRAS like proto-oncogene B. (206 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
LOC100714922Ion_trans domain-containing protein. (685 aa)
Gdf1TGF_BETA_2 domain-containing protein. (367 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (873 aa)
HTTHuntingtin. (3133 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (278 aa)
ENSCPOP00000023749Uncharacterized protein. (244 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (699 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (222 aa)
ORMDL3ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)
BNIP3LBCL2 interacting protein 3 like. (214 aa)
LOC100714924Uncharacterized protein. (288 aa)
Pafah1b2SGNH_hydro domain-containing protein. (202 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (240 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (541 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (987 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (416 aa)
TLR2Toll like receptor 2; Belongs to the Toll-like receptor family. (782 aa)
HMOX1Heme oxygenase 1. (297 aa)
ENDOGEndonuclease. (299 aa)
SH3BP4SH3 domain binding protein 4. (964 aa)
RAB12RAB12, member RAS oncogene family. (210 aa)
ADRB2Beta-2 adrenergic receptor; Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. (418 aa)
H0W5F0_CAVPOBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (187 aa)
Foxo3Forkhead box O3. (660 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (443 aa)
SESN3Sestrin 3. (414 aa)
RB1CC1RB1 inducible coiled-coil 1. (1431 aa)
Rnf31Uncharacterized protein. (1072 aa)
PLK2Serine/threonine-protein kinase PLK. (682 aa)
H0VXJ2_CAVPOUncharacterized protein. (240 aa)
TRIM13Tripartite motif containing 13. (407 aa)
LOC100727489Uncharacterized protein. (534 aa)
GPSM1G protein signaling modulator 1. (706 aa)
LOC100728392Interferon-gamma-inducible GTPase IFGGD1 protein. (398 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (419 aa)
PINK1PTEN induced kinase 1. (574 aa)
ATG101Autophagy related 101. (218 aa)
WDR24WD repeat domain 24. (790 aa)
TRIM65Tripartite motif containing 65. (515 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (461 aa)
FBXO7F-box protein 7. (524 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (446 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
SESN1Sestrin 1. (564 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (789 aa)
DDIT3DNA damage inducible transcript 3. (167 aa)
FLCNFolliculin. (579 aa)
TRIM8Tripartite motif containing 8. (460 aa)
TRIM27Tripartite motif containing 27. (504 aa)
TRIM21Tripartite motif containing 21. (467 aa)
SNX30Sorting nexin family member 30. (493 aa)
GNAI3Guanine nucleotide-binding protein G(i) subunit alpha; Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modul [...] (354 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (550 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
TBK1TANK binding kinase 1. (729 aa)
TRIML1Tripartite motif family like 1. (474 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4228 aa)
ATF6Activating transcription factor 6. (659 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1033 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1345 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MefvUncharacterized protein. (618 aa)
C9orf72C9orf72-SMCR8 complex subunit. (481 aa)
SMCR8SMCR8-C9orf72 complex subunit. (936 aa)
SNX4Sorting nexin 4. (403 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
H0VCZ7_CAVPOFork-head domain-containing protein. (548 aa)
ATG2AAutophagy related 2A. (1904 aa)
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2. (1314 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1440 aa)
OPTNOptineurin. (576 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (398 aa)
BAG3BCL2 associated athanogene 3. (572 aa)
UFL1UFM1 specific ligase 1. (762 aa)
RIPK2Receptor interacting serine/threonine kinase 2. (442 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (370 aa)
Depdc5DEP domain-containing protein. (1576 aa)
CDK16Cyclin dependent kinase 16; Belongs to the protein kinase superfamily. (496 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (362 aa)
TPCN1Two pore channel 1. (817 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (828 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (845 aa)
TSC1TSC complex subunit 1. (1166 aa)
H0V0S2_CAVPOB box-type domain-containing protein. (274 aa)
LARP1La ribonucleoprotein domain family member 1. (954 aa)
TSC2TSC complex subunit 2. (1745 aa)
MAP2K1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (393 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
PLK3Serine/threonine-protein kinase PLK. (646 aa)
HPSEHeparanase. (526 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (562 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
SIRT1Sirtuin 1. (717 aa)
TRIML2Tripartite motif family like 2. (431 aa)
AGERAdvanced glycosylation end-product specific receptor. (377 aa)
SESN2Sestrin 2. (480 aa)
PIK3C2APhosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1404 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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