STRINGSTRING
FDPS FDPS TRIP10 TRIP10 GSK3B GSK3B AKAP1 AKAP1 JARID2 JARID2 ROCK2 ROCK2 MTOR MTOR TOMM70 TOMM70 ROCK1 ROCK1 Cdk9 Cdk9 FBXO32 FBXO32 PPP3CA PPP3CA H0VDT0_CAVPO H0VDT0_CAVPO PDE5A PDE5A AKAP6 AKAP6 SMAD4 SMAD4 SLC25A4 SLC25A4 ADK ADK P2rx4 P2rx4 Glrx3 Glrx3 CTDP1 CTDP1 DDX39B DDX39B PPARG PPARG TWF1 TWF1 TRPC3 TRPC3 PTK2 PTK2 SIRT1 SIRT1 PAK1 PAK1 PIN1 PIN1 RGS4 RGS4 ADRB1 ADRB1 TRIM63 TRIM63 PARP2 PARP2 P2rx7 P2rx7 PI16 PI16 TNFRSF1B TNFRSF1B G6PD G6PD GSK3A GSK3A BMP10 BMP10 AGT AGT RGS2 RGS2 MEF2C MEF2C MTPN MTPN PDE9A PDE9A GATA5 GATA5 SLC9A1 SLC9A1 NR4A3 NR4A3 LMCD1 LMCD1 EDN1 EDN1 TNFRSF1A TNFRSF1A Mlip Mlip Camk2d Camk2d CAV3 CAV3 SMAD3 SMAD3 ADRA1A ADRA1A BECN1 BECN1 MEF2A MEF2A IGF1 IGF1 ERRFI1 ERRFI1 HAND2 HAND2 ATP2B4 ATP2B4 CCN4 CCN4 Foxp1 Foxp1 ENSCPOP00000024428 ENSCPOP00000024428 HAMP HAMP Yy1 Yy1 ENSCPOP00000025546 ENSCPOP00000025546 LMNA LMNA Parp1 Parp1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FDPSFarnesyl diphosphate synthase; Belongs to the FPP/GGPP synthase family. (352 aa)
TRIP10Thyroid hormone receptor interactor 10. (546 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
AKAP1A-kinase anchoring protein 1. (860 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1247 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1371 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
Cdk9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (372 aa)
FBXO32F-box protein 32. (355 aa)
PPP3CASerine/threonine-protein phosphatase. (518 aa)
H0VDT0_CAVPOProtein kinase domain-containing protein. (337 aa)
PDE5APhosphodiesterase. (863 aa)
AKAP6A-kinase anchoring protein 6. (2208 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SLC25A4Solute carrier family 25 member 4; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
ADKAdenosine kinase. (362 aa)
P2rx4Uncharacterized protein. (343 aa)
Glrx3Uncharacterized protein. (171 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
DDX39BDExD-box helicase 39B. (428 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
TWF1Twinfilin actin binding protein 1. (337 aa)
TRPC3ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (849 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1084 aa)
SIRT1Sirtuin 1. (717 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (166 aa)
RGS4Regulator of G protein signaling 4. (205 aa)
ADRB1G_PROTEIN_RECEP_F1_2 domain-containing protein. (470 aa)
TRIM63Tripartite motif containing 63. (329 aa)
PARP2Poly [ADP-ribose] polymerase. (536 aa)
P2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
PI16Peptidase inhibitor 16; Belongs to the CRISP family. (508 aa)
TNFRSF1BTNF receptor superfamily member 1B. (482 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
GSK3AGlycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MTPNMyotrophin. (118 aa)
PDE9APhosphodiesterase. (534 aa)
GATA5GATA binding protein 5. (292 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (810 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (633 aa)
LMCD1LIM and cysteine rich domains 1. (365 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (208 aa)
TNFRSF1ATNF receptor superfamily member 1A. (469 aa)
MlipUncharacterized protein. (298 aa)
Camk2dProtein kinase domain-containing protein. (532 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ADRA1AAlpha-1A adrenergic receptor; This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity). (466 aa)
BECN1Beclin 1. (448 aa)
MEF2AMyocyte enhancer factor 2A. (517 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (153 aa)
ERRFI1ERBB receptor feedback inhibitor 1. (462 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CCN4Cellular communication network factor 4. (367 aa)
Foxp1Fork-head domain-containing protein. (687 aa)
ENSCPOP00000024428PARP-type domain-containing protein. (104 aa)
HAMPHepcidin antimicrobial peptide. (84 aa)
Yy1Uncharacterized protein. (195 aa)
ENSCPOP00000025546Uncharacterized protein. (58 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (624 aa)
Parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
Your Current Organism:
Cavia porcellus
NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig
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