30 items (Cavia porcellus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMP10	Bone morphogenetic protein 10. (424 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (462 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (504 aa)
	CTDP1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (956 aa)
	Glrx3	Uncharacterized protein. (171 aa)
	P2rx4	Uncharacterized protein. (343 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	FBXO32	F-box protein 32. (355 aa)
	TOMM70	Translocase of outer mitochondrial membrane 70. (609 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1247 aa)
	AKAP1	A-kinase anchoring protein 1. (860 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (423 aa)
	GSK3A	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily. (470 aa)
	G6PD	Glucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (515 aa)
	TNFRSF1B	TNF receptor superfamily member 1B. (482 aa)
	PI16	Peptidase inhibitor 16; Belongs to the CRISP family. (508 aa)
	TRIM63	Tripartite motif containing 63. (329 aa)
	Yy1	Uncharacterized protein. (195 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (624 aa)
	RGS2	Regulator of G protein signaling 2. (211 aa)
	ATP2B4	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
	Foxp1	Fork-head domain-containing protein. (687 aa)
	ENSCPOP00000025546	Uncharacterized protein. (58 aa)
	RGS4	Regulator of G protein signaling 4. (205 aa)
	GATA5	GATA binding protein 5. (292 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (469 aa)
	Mlip	Uncharacterized protein. (298 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (152 aa)

Your Current Organism:

Cavia porcellus

NCBI taxonomy Id: 10141
Other names: C. porcellus, Cavia aperea porcellus, Cavia cobaya, domestic guinea pig, guinea pig

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP10	SMAD4	ENSCPOP00000021103	ENSCPOP00000005827	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.585
CAV3	GSK3A	ENSCPOP00000030684	ENSCPOP00000019863	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.549
CAV3	GSK3B	ENSCPOP00000030684	ENSCPOP00000012892	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.551
CAV3	LMNA	ENSCPOP00000030684	ENSCPOP00000015745	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Lamin A/C; Belongs to the intermediate filament family.	0.423
CAV3	PPARG	ENSCPOP00000030684	ENSCPOP00000001849	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.483
CTDP1	TOMM70	ENSCPOP00000002374	ENSCPOP00000010141	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II.	Translocase of outer mitochondrial membrane 70.	0.416
FBXO32	TRIM63	ENSCPOP00000008950	ENSCPOP00000018077	F-box protein 32.	Tripartite motif containing 63.	0.760
GATA5	Glrx3	ENSCPOP00000027056	ENSCPOP00000002566	GATA binding protein 5.	Uncharacterized protein.	0.400
GSK3A	CAV3	ENSCPOP00000019863	ENSCPOP00000030684	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.549
GSK3A	GSK3B	ENSCPOP00000019863	ENSCPOP00000012892	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	0.929
GSK3A	RGS2	ENSCPOP00000019863	ENSCPOP00000021444	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Regulator of G protein signaling 2.	0.748
GSK3A	RGS4	ENSCPOP00000019863	ENSCPOP00000026639	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Regulator of G protein signaling 4.	0.748
GSK3A	SMAD3	ENSCPOP00000019863	ENSCPOP00000031052	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.462
GSK3B	CAV3	ENSCPOP00000012892	ENSCPOP00000030684	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.551
GSK3B	GSK3A	ENSCPOP00000012892	ENSCPOP00000019863	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 alpha; Belongs to the protein kinase superfamily.	0.929
GSK3B	PPARG	ENSCPOP00000012892	ENSCPOP00000001849	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.414
GSK3B	RGS2	ENSCPOP00000012892	ENSCPOP00000021444	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Regulator of G protein signaling 2.	0.748
GSK3B	RGS4	ENSCPOP00000012892	ENSCPOP00000026639	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Regulator of G protein signaling 4.	0.748
GSK3B	SMAD3	ENSCPOP00000012892	ENSCPOP00000031052	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.745
GSK3B	SMAD4	ENSCPOP00000012892	ENSCPOP00000005827	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.440